Navigation Links
A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease
Date:4/2/2008

lung cancer and peripheral arterial disease,' is published today in the online edition of Nature, at http://www.nature.com.

"These findings provide an example of the power of human genetics for shedding light on the most complex health challenges. Not only have we made a convincing link between a single SNP and a behavioral disorder -- greater smoking quantity and addiction to nicotine -- but also demonstrated how this risk factor translates into risk of lung cancer and PAD. This is an important advance that we will use in our diagnostics programs to develop means to enable individuals and their doctors to better understand and reduce the risk of smoking to their health. As of today we have also integrated this variant into our deCODEme(TM) personal genome analysis service," said Kari Stefansson, CEO of deCODE.

The deCODE team began this study with a smoking history questionnaire distributed to some 50,000 Icelanders, in which respondents were asked to say whether they had ever smoked, were still smokers, and, if so, how many cigarettes they smoked per day. More than 300,000 SNPs were then analysed in a subset of more than 10,000 smokers participating in deCODE's research, and the "T" version SNP rs1051730 was shown to be more common in heavier smokers than in smokers overall and in the general population. It was also correlated with likelihood of clinical diagnosis of nicotine dependence. Interestingly, the variant is less common among smokers who smoked less than 10 cigarettes per day than it is among non-smokers, supporting the notion that the variant does not influence smoking initiation, but rather confers risk of nicotine dependence among those who start. The variant was then analyzed in a total of 32,000 patients and controls from Iceland, New Zealand, Austria, Sweden, Italy, the Netherlands and Spain for lung cancer and PAD, two common diseases strongly associated with smoking.

deCODE gra
'/>"/>

SOURCE deCODE
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Misperceptions About Smoking Cessation Aids May Hinder Smokers From Using Effective Treatment for Quitting
2. Evotec Starts Phase II in Smoking Cessation with EVT 302
3. Transgene: Cash Position of EUR 119 Million as of September 30, 2007
4. deCODE genetics to Webcast Presentation at 15th Annual Future Leaders in the Biotech Industry Conference
5. deCODE genetics to Webcast Presentation at Lehman Brothers Eleventh Annual Global Healthcare Conference
6. deCODE Genetics Announces Full-year 2007 Financial Results
7. deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results
8. deCODE genetics to Webcast Presentation at BIO CEO and Investor Conference
9. deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women
10. deCODE genetics to Webcast Presentation at JPMorgan Annual Healthcare Conference
11. deCODE Launches deCODEme(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2015)... 2015  Scientists from Cleave Biosciences will be participating ... at the American Association for Cancer Research Annual Meeting ... Sunday, April 19, 2015 from 3:15pm to 5:15pm ET. ... will present new in vivo and mechanism of action ... p97, a critical enzyme that controls various aspects of ...
(Date:4/16/2015)... LAUSANNE , Switzerland ... Debiopharm International SA (Debiopharm), part of Debiopharm Group ™ ... prescription drugs that target unmet medical needs ... that preclinical data on the investigational compounds ... inhibitor) will be presented at the 2015 ...
(Date:4/16/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ... DCVax® personalized immune therapies for cancer, announced today ... Cancer Immunotherapy Index (LCINDX), a professional index recently ... field within the biotechnology space.  ... companies" in the immunotherapy space, including 6 big ...
(Date:4/16/2015)... 2015 CCI Global Channel Management, the ... planning management software for major tech and telecom vendors, ... survey of channel vendor programs in software, hardware, and ... How the top IT vendors in each segment ... coming year. , Assessment of the state ...
Breaking Biology Technology:Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 2Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 3NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3CCI’s Channel Program Study Reveals 40% of IT Vendor Channel Staff Lack Adequate Access to Program and Partner Data 2CCI’s Channel Program Study Reveals 40% of IT Vendor Channel Staff Lack Adequate Access to Program and Partner Data 3
... what could be a shot in the arm for ... enhancing and controlling the growth of T cells in ... one of the therapy,s drawbacks. The engineers altered ... in which researchers can build new functions into cells ...
... TRIANGLE PARK, N.C. , April 26 Talecris Biotherapeutics Holdings ... results on April 28, 2010 , after the stock market closes ... on April 29, 2010 . , ... Investors and analysts may participate via phone by ...
... Volcano Corporation (Nasdaq: VOLC ), a leading developer and manufacturer ... treatment of coronary and peripheral vascular disease, today announced that it will ... Monday, May 3 . , ... The company will hold a conference call to discuss its financial ...
Cached Biology Technology:New technique reinforces immune cells that seek and destroy cancer, says Stanford researcher 2New technique reinforces immune cells that seek and destroy cancer, says Stanford researcher 3Talecris Biotherapeutics to Report First Quarter 2010 Financial Results 2Volcano Corporation Schedules First Quarter Conference Call, Webcast 2
(Date:3/31/2015)... 31, 2015  Elephant Talk Communications Corp. (NYSE MKT: ... of Software Defined Network Architecture (ET Software DNA® 2.0) ... of approximately $20.4 million for the year ended December ... for the year ended December 31, 2013. ... had completed its multi-year transition away from its legacy ...
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... the "Global Gesture Recognition Market in Automotive Sector ... analysts forecast the Global Gesture Recognition market in Automotive ... the period 2013-2018. Gesture recognition is the ... different gestures of an individual. Gesture recognition technology can ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... U.S. Department of Homeland,Security (DHS) announced today ... international visitors arriving at New York,s John ... part of the department,s,upgrade from two- to ... travel by more accurately and efficiently,establishing and ...
... that guide one of the two groups of pathogenic ... defense against the world. The work, they said, ... bacteria, like E. coli and salmonella, that would destroy ... protective coating. "A long-term goal is to find ...
... gene is integral to both fungal invasion of corn and ... lead to ways to control the pathogen and the poison. ... found that it is vital to the process of the ... when the scientists disabled the gene. At certain levels, ...
Cached Biology News:DHS Begins Collecting 10 Fingerprints From International Visitors at New York's John F. Kennedy International Airport 2Ant guts could pave the way for better drugs 2Defining gene's role may lead to prevention of dangerous corn toxin 2Defining gene's role may lead to prevention of dangerous corn toxin 3
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
... 1 kit. Facilitates the simple, phenol-free extraction ... hard tissue requiring proteinase K digestion.Each kit ... from 50 preparations of up to 25 ... & Purification, Purification and Amplification of Genomic ...
Request Info...
Ultra-sensitive, non-radioactive measurement of COX-I and COX-II activity...
Biology Products: