Navigation Links
A Genetic Approach For Crohn's And Colitis Disease Is Financed By The Jeffrey Epstein VI Foundation
Date:7/3/2012

NEY YORK, July 3, 2012  /PRNewswire/ -- The Jeffrey Epstein VI Foundation, which actively supports science research, has given substantial support to the Crohn's and Colitis Foundation of America to continue its Genetic Initiative to find a cure for the diseases.

Crohn's is a chronic inflammatory condition of the gastrointestinal tract. Every year, about 700,000 Americans are diagnosed, the majority being between the ages of 15 and 35. Crohn's affects the end of the small bowel, or ileum, the beginning of the colon and parts of the gastrointestinal tract. Ulcerative colitis affects the colon or large intestine.

The cause of Crohn's and Colitis is uncertain but the chronic inflammation stems from the immune system attacking microbial antigens in the gastrointestinal tract. Because of this, the disease is classified as an autoimmune disorder.

What is certain however is that Crohn's has a strong genetic component. Siblings are 30 times more likely to develop Crohn's than the general population. Children of those affected, are 3 to 20 times more likely to develop the disease and twins show a concordance of over 55%.

The Genetic Initiative at the Crohn's and Colitis Foundation of America, which recently received funding from The Jeffrey Epstein VI Foundation, is by far the most comprehensive effort of its kind to isolate the mutated genes that lead to the disease. The Initiative employs a dream team of specialists from different fields to identify genetic mutations and the chain of subsequent pathologies that cause Crohn's and Colitis. The Initiative is headed by Dr. Ramnik Xavier, Chairman of the Department of Gastroenterology at Massachusetts General Hospital in Boston. Xavier's laboratory has identified the largest number of genes associated with Crohn's to date. He is also a founding member of the Center for Computational and Integrative Biology.

The first mutation associated with Crohn's was the NOD2 gene (or CARD15) followed by the discovery of point mutations. Currently, more than thirty genetic mutations have been found, along with their consequences. Mutations of the XBP1 gene for example, directly affect the endoplasmatic reticulum's unfolded protein response pathway. The genetic mutation of ATG16L1 typically induces cell autophagy and can hinder the body's ability to attack invasive bacteria.

"As pluripotent stem cell technology improves, databases like the Genetic Initiative will be invaluable resources to curing such diseases as Crohn's and Colitis," Jeffrey Epstein remarks.

Founded in 1967, the Crohn's and Colitis Foundation of America is a non-profit organization dedicated to finding cures for Crohn's and ulcerative colitis. The Jeffrey Epstein VI Foundation was established in 2000 by science investor and financier, Jeffrey Epstein. Jeffrey Epstein has been an active supporter of genetic research, including the renowned Broad Institute which studies the entire human genome.

 


'/>"/>
SOURCE www.jeffreyepstein.org
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. First Genetic Cure For Cancer Anchors Provocative New Thriller
2. Applied Genetics Initiates Commercial Operation
3. BioRealm to Develop Universal Genetic Screening Tool for Tobacco Addiction and Treatment
4. U.S. Senate Urged to Increase Federal Funding for Research into Hereditary Angioedema, a Rare and Serious Genetic Disorder
5. Study suggests expanding the genetic alphabet may be easier than previously thought
6. Roche 454 Life Sciences and SoftGenetics Sign Co-Promotion Agreement for Next-Gen Sequencing Software Tools
7. JS Genetics announces launch of XCAT-KS, a bloodless, cheek swab test for the diagnosis of Klinefelter syndrome and other Male sex chromosome aneuploidies
8. Global Genetic Engineering Industry
9. Quest Diagnostics Announces C9orf72 Genetic Test for ALS (Lou Gehrigs Disease)
10. Roche Launches 454 Sequencing Assays for High Sensitivity Genetic Variant Detection in Leukemia Samples to Drive Blood Cancer Research Worldwide
11. Khan Academy and 23andMe Partner to Promote Genetics Education on DNA Day
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... In today,s pre-market research, Stock-Callers.com ... Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate Pharmaceuticals ... and Regulus Therapeutics Inc. (NASDAQ: RGLS ). ... its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn more ... ...
(Date:3/22/2017)... Denmark , March 22, 2017  Ascendis ... utilizes its innovative TransCon technology to address significant ... financial results for the full year ended December ... significant year for our company as we broadened ... a leading, integrated rare disease company with an ...
(Date:3/22/2017)... 2017   iSpecimen ®, the marketplace ... Pathology Service (DPS), a full-service anatomic pathology reference ... United States , has joined a program offered ... (DHIN) to make human biospecimens and associated data ... program, announced in 2015 as a collaboration between iSpecimen ...
(Date:3/22/2017)... 22, 2017   Boston Biomedical , an industry ... to target cancer stemness pathways, today announced its Board ... as Chief Executive Officer, effective April 24, 2017. ... Li , M.D., FACP, who has led Boston Biomedical ... his leadership, Boston Biomedical has grown from a "garage ...
Breaking Biology Technology:
(Date:3/2/2017)... LONDON , March 2, 2017 Who ... infringement lawsuits? Download the full report: https://www.reportbuyer.com/product/4313699/ ... ON THE FINGERPRINT SENSOR FIELD? Fingerprint sensors using ... smartphones. The fingerprint sensor vendor Idex forecasts an increase ... in mobile devices and of the fingerprint sensor market ...
(Date:2/28/2017)... News solutions for biometrics, bag drop and New ADA-compliant kiosk ... At PTE 2017 ... Materna will present its complete end-to-end passenger journey, from ... benefit for passengers. To accelerate the whole passenger handling process, ... to take passengers through the complete integrated process with a ...
(Date:2/24/2017)... Feb. 24, 2017  EyeLock LLC, a leader of iris-based ... iris biometric solution on the latest Qualcomm® Snapdragon™ ... Mobile World Congress 2017 (February 27 – ... Hall 3, Stand 3E10. The ... security platform—a combination of hardware, software and ...
Breaking Biology News(10 mins):