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960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter
Date:3/18/2008

occur when micro-organisms contaminate the catheter. Catheter related bloodstream infections are estimated to occur at an annual rate of 80,000 to 250,000 cases in the US, resulting in increased mortality, cost, and length of stay.(1-4) The attributable mortality of CRBSI is estimated at 11%.(5) In the U.S., the cost per catheter-related infection can range from $3,700 to $29,000.(6) In addition, the Centers for Disease Control and Prevention (CDC) has raised concerns about the overuse of traditional antibiotics and antiseptics, which can contribute to an increase in bacterial resistance.

About Angiotech's 5-FU CVC

Angiotech has demonstrated that 5-FU, a well-known and approved compound, has utility to prevent catheter-related infections as effectively as traditional antiseptics and antibiotics. In addition, since 5-FU has no clinical application as either a systemic antibiotic or a hospital antiseptic, there is a reduced risk to the hospital or the community at-large of creating a "super-bug" that may be resistant to useful classes of antibiotics and antispectics and may make infection control more complex. The alarming increase in microbial resistance is one of the CDC's top concerns.

The principle behind using 5-FU on a CVC is that the drug acts through multiple pathways to inhibit bacterial growth and metabolic functions of most microorganisms. Adding a very minute amount of 5-FU to the surface of a device makes that surface a very hostile environment for a microorganism, with unchanged tolerability for the patient. Our 5-FU technology can also effectively impair biofilm formation that may lead to colonization and infection. This reduction in colonization by bacteria may have a net effect of reducing biofilm burden on the implanted devices, making them less likely to serve as reservoirs for additional infection.

Note on Forward Looking Statements

Statements contained in this press release that are not based on historical fact,
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SOURCE Angiotech Pharmaceuticals, Inc.
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