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960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter
Date:3/18/2008

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Catheter colonization 2.9% 5.3% Yes

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Catheter-related blood stream

infections 0% 2.8% p= 0.2

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Adverse Events, related to study

device 2.5% 3.1% N/A

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Microbiology

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Coagulase-negative staphylococcus 4 8

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Methicillin-resistant

staphylococcus aureus 0 3

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Gram-negative bacteria 0 6(x)

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Fungal species 0 2(x)

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(x) Including catheter-related blood stream infection

As important as the zero rate of catheter-related blood stream infection, the low rate of colonization and the types of organisms implicated are also important. The Angiotech 5-FU coated CVCs were infrequently colonized, and only with S. epidermis and common skin contaminants. In addition to S. epidermis and common skin contaminants, the catheters with CH-SS were also colonized with methicillin-resistant S. aureus, E. coli, K. pneumoniae, P. mirabilis, S. marcescens, and A. baumannii. Both of the blood stream infections in this study were associated with the CH-SS catheter which grew Candida and gram-negative bacteria, pathogens associated with poor patient outcomes. The spectrum of organisms involved will give clinicians reason to choose
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SOURCE Angiotech Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
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