Navigation Links
454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation
Date:9/27/2007

BRANFORD, Conn., Sept. 27 /PRNewswire/ -- 454 Life Sciences, a Roche company, in collaboration with Yale University researchers today announced that they have developed a method, using the company's Genome Sequencer(TM) FLX system, to identify significant human genetic variability with an unprecedented level of detail. The new method enables researchers to analyze genome-wide structural variations (SV), the gross changes to the genetic code in a very fast and economic way. The study, entitled "Paired-End Mapping Reveals Extensive Genomic Structural Variation in Humans," appears online (ahead of print) today in the journal Science.

Previous studies of human genomic variation tended to look at changes called single nucleotide polymorphism, variations that involve just one nucleotide, commonly referred to as SNP. However, the study published today suggests that structural variation is responsible for a larger number of differences between the genomes of two individuals than SNPs. Furthermore, structural variation may have notable physical effects on an individual. The role that SV plays in human variability has not been well understood because of cost-prohibitive and imprecise technology used in previous research. The novel approach described today in Science, called Paired End Mapping (PEM), used 454 Sequencing to comprehensively study SV at an unmatched level of resolution, detecting most of the structural variation in the human genome.

"454 Sequencing enabled us to efficiently identify over 1000 structural variations in two individuals. Our study demonstrates that a large number of SVs are present in the human population and that SV plays a greater role in genetic diversity than SNP," explained Michael Snyder, PhD., senior author and Lewis B. Cullman Professor of Molecular, Cellular and Developmental Biology and Professor of Molecular Biophysics and Biochemistry and Director of the Yale Center for Genomics and Proteomics. "The widespread occurrenc
'/>"/>

SOURCE 454 Life Sciences
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Advantages of Roche Applied Science amplification products
2. Tools for Proteomic Science II
3. Exploiting the Life Science Data Explosion to Speed New Drug Discovery
4. Food science: increasing crop yields
5. Automation of the Eppendorf Perfectprep BAC 96 DNA Kit on the Caliper Life Sciences Sciclone ALH 3000
6. World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition
7. NanoRite Innovation Center opens with small science, big promise
8. Midwest life science stocks kept sizzling in Q2
9. Perscitus Biosciences secures $250K Commerce loan
10. Wisconsin biosciences rise to the challenge
11. Wisconsin professors elected to National Academy of Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... Swecure, ein Biotechnologieunternehmen, ... Entwicklung neuartiger Therapien für Störungen des Immunsystems ... konzentriert, erhält vom US Patent and Trademark ... patentiert wird. Das Medikament basiert auf einem ... und Entzündungen vorbeugt.   Das Medikament, ...
(Date:9/1/2015)... The American Brain Tumor Association (ABTA) is ... Research Grant program. LOIs are due no later than ... Discovery Grants are one-year, $50,000 grants that fund ... current diagnostic or treatment paradigms for adults and children ... at its earliest stages, in the hopes that it ...
(Date:9/1/2015)... , Sept. 1, 2015 Prostate ... death in American men. One in seven ... 233,000 new cases are diagnosed annually. That said, ... using a powerful new technique, MRI Fusion Biopsy, ... large cancer lesions, treating only the affected areas ...
(Date:9/1/2015)... ... September 01, 2015 , ... In her thought provoking debut novel ‘ Ebola ... not-so-distant future faced with an Ebola pandemic that is on the cusp of wiping ... enter the world of counterterrorism, and who continues to appear in this series of ...
Breaking Biology Technology:Das Patent von Swecure zur Verhinderung von Allergien bei Kindern wird in den USA zugelassen 2American Brain Tumor Association Seeks Innovative Concepts For Discovery Research Grants 2September Is Prostate Cancer Awareness Month 2September Is Prostate Cancer Awareness Month 3September Is Prostate Cancer Awareness Month 4Alexi Venice’s Debut Novel Takes on the Human Testing of a Vaccine for Ebola and Revenge by an Anti-Big Pharma Terrorist Group in ‘Ebola Vaccine Wars' 2Alexi Venice’s Debut Novel Takes on the Human Testing of a Vaccine for Ebola and Revenge by an Anti-Big Pharma Terrorist Group in ‘Ebola Vaccine Wars' 3
... -- FirstMark, the diagnostic division of GenWay Biotech, Inc., ... exhibiting at the 61st Annual Scientific Sessions & Expo ... March 24-27, Booth #15084. FirstMark will showcase the new ... multiple biomarker blood test that accurately predicts near term ...
... Alliance, an inVentiv Health company and the leading ... biotech industry, today announced the launch of Encuity ... Turner, a six-year veteran with Campbell Alliance, will ... will be based in Newtown, PA. ...
... which, in living cells, emits turquoise light three times ... of cellular imaging, a technique where biological processes inside ... results have been published in Nature Communications ... the publication is Antoine Royant from the Institut de ...
Cached Biology Technology:FirstMark Exhibiting at the American College of Cardiology 61st Annual Scientific Sessions & Expo 2Campbell Alliance Launches Market Research and Analytics Group, Appoints Michael Turner as General Manager of Encuity Research 2Campbell Alliance Launches Market Research and Analytics Group, Appoints Michael Turner as General Manager of Encuity Research 3Campbell Alliance Launches Market Research and Analytics Group, Appoints Michael Turner as General Manager of Encuity Research 4Campbell Alliance Launches Market Research and Analytics Group, Appoints Michael Turner as General Manager of Encuity Research 5Proteins shine a brighter light on cellular processes 2
(Date:8/24/2015)... South Africa , August 24, 2015 ... Germany ,s largest biometrics manufacturer DERMALOG and its ... with the "2015 African Biometrics Company of the Year Award". ... Nigeria .   -Cross reference: ... http://www.presseportal.de/nr/8896 - On Thursday evening, in ...
(Date:8/19/2015)... , Aug. 19, 2015  VOXX International ... it has entered into a Definitive Agreement to ... of iris authentication market leader EyeLock through an ... will have a controlling interest in the acquiring ... to completion of due diligence.  Expanding on its ...
(Date:8/12/2015)... SPRINGS, Florida , August 12, 2015 ... the pace of mobile payment innovation and advanced biometrics ... to replace the way consumers rely on using their ... ahead with reinventing the future for payment services led ... (NASDAQ: NXTD ), :  Google, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... can skim through certain kinds of damaged DNA without ... performed in bacteria, suggest a new mechanism that can ... results were published online this week in the ... senior author is Paul Doetsch, PhD, professor of biochemistry ...
... from the Hood Center for Children and Families at Dartmouth ... the significant potential negative impact that food product placements in ... which appears in the current edition of the journal ... food, beverage, and food retail establishments that are frequently portrayed ...
... at Barrow Neurological Institute at St. Joseph,s Hospital and ... of a new category of painkillers, called TRPV1 antagonists. ... vannilloid-1 (TRPV1) channel, which is the same receptor responsible ... clinical trials have revealed that TRPV1 antagonists cause hyperthermia- ...
Cached Biology News:Cells can read damaged DNA without missing a beat 2New study examines the impact on children of food product placements in the movies 2New study examines the impact on children of food product placements in the movies 3New era of pain drugs advanced by Barrow researcher 2
... sets a new standard for high performance ... new design in instrumentation, this easy-to-use benchtop ... The BD FACSAria instrument is the first ... flow cell. This new flow cell ...
Mouse monoclonal antibody raised against a partial recombinant COG2. NCBI Entrez Gene ID = COG2...
Mouse polyclonal antibody raised against a partial recombinant IFNA13. NCBI Entrez Gene ID = 3447...
Mouse monoclonal antibody raised against a full length recombinant LDB3. NCBI Entrez Gene ID = LDB3...
Biology Products: