Navigation Links
2 problems in chemical catalysis solved
Date:12/20/2012

The research group of Professor Petri Pihko at the Department of Chemistry and the NanoScience Center of the University of Jyvskyl has solved two acute problems in chemical catalysis. The research has been funded by the Academy of Finland.

In the first project, the researchers designed a novel intramolecularly assisted catalyst for the synthesis of beta amino acids. Previously published catalysts work only with aromatic side chains in the imines, but the new catalyst designed at Jyvskyl does not have this limitation. The new method might find uses in the synthesis of beta amino acids, which are important building blocks for chemical biology. For the understanding of the catalytic mechanism and design of the catalyst, the researchers collaborated with the group of Imre Ppai (Hungarian Academy of Sciences, computational studies) and Academy Professor Kari Rissanen (Jyvskyl, X-ray characterisation of catalysts).

In the second project, the researchers identified a completely new mechanism for the amine-catalysed Michael addition reaction between aldehydes and nitroalkenes. The mechanism has been a source of intense discussion within the scientific community, with the groups of Professor Yujiro Hayashi (Tokyo), Professor Donna Blackmond (La Jolla, USA) and Professor Dieter Seebach (ETH, Switzerland) each presenting different possible mechanisms.

The new model proposed by the Pihko and Papai groups includes a new species, a six-membered ring, as the key on-cycle intermediate that is protonated in the rate-determining step. The work is a combination of computational and experimental studies that complement each other in understanding the mechanism and demonstrate how difficult mechanistic puzzles can be solved by joining the forces of both approaches.


'/>"/>

Contact: Petri Pihko
petri.pihko@jyu.fi
358-505-289-132
Academy of Finland
Source:Eurekalert  

Page: 1

Related biology technology :

1. Cold Adds Up to Sandy Victims' Mold Problems; Optimal Chemical Reaches Out to Help by Advising the Use of Molderizer
2. Entrepreneurs to Eat Problems for Breakfast in San Diego
3. A thin-skinned catalyst for chemical reactions
4. 20% Off Your Entire Order of Scientific, Technical, Medical (STM) Titles Until the End of December at Chemical Publishing Company
5. Chemical Publishing Company Announces its Niche Catalog in the Water Technology and Water Treatment Space
6. Piedmont Chemical Launches 100 Percent Renewable Polyester Polyols Leveraging Renewable Chemicals from DuPont Tate & Lyle Bio Products and Myriant Corporation
7. Researchers improve technology to detect hazardous chemicals
8. From lectures to explosives detection: Laser pointer identifies dangerous chemicals in real-time
9. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
10. ESTEVE Announces the Publication of Comprehensive Phase I Data for a Novel Oral, First-in-class New Chemical Entity (NCE),E-52862, a Sigma-1 Receptor Antagonist (S1RA) Being Developed for Pain
11. Chemical makes blind mice see; compound holds promise for treating humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 problems in chemical catalysis solved
(Date:5/22/2017)... ... , ... Stratevi, a boutique firm that partners with healthcare companies to creatively ... office in downtown Boston at 745 Atlantic Ave. , “We are seeing that ... on the value they provide, not just to patients, but also payers. Having a ...
(Date:5/21/2017)... ... May 20, 2017 , ... CNSDose ... lengthy trial and error process by finding the right antidepressant faster. CNSDose ... the doctor-patient relationship through a personalized approach to treatment. , A ...
(Date:5/18/2017)... ... May 18, 2017 , ... Lajollacooks4u has added another ... a two-hour team-building package designed for groups of 10-30 people. Guests can ... include items, such as Blackened Shrimp with Edamame Salad, Pizza Rolls with Pepperoni ...
(Date:5/18/2017)... Massachusetts (PRWEB) , ... May 17, 2017 , ... ... company specializing in medical device compliance and commercialization, has just released version 9.0 ... of work into this latest version of Cockpit,” says David Cronin, CEO of ...
Breaking Biology Technology:
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
(Date:3/24/2017)... MILAN , March 24, 2017 The Controller ... Deputy Controller Mr. Abdulla Algeen have received the prestigious international ... Continue Reading ... ... small picture) and Deputy Controller Abdulla Algeen (small picture on the right) ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
Breaking Biology News(10 mins):