Navigation Links
Scientists develop new technique that could improve heart attack prediction
Date:4/30/2012

An award-winning research project, funded by the British Heart Foundation (BHF), has tested a new imaging method which could help improve how doctors predict a patient's risk of having a heart attack (1).

Scientists from the University of Edinburgh, a BHF Centre of Research Excellence, in collaboration with the University of Cambridge are the first to demonstrate the potential of combining PET and CT scanning to image the disease processes directly in the coronary arteries that cause heart attacks (2).

There are nearly 2.7 million people living with coronary heart disease (CHD) in the UK and it kills 88,000 people each year. Most of these deaths are caused by a heart attack. Each year there are around 124,000 heart attacks in the UK (3).

The research, published in the Journal of the American College of Cardiology (JACC) (4), involved giving over 100 people a CT calcium score to measure the amount of calcified or hardened plaques in their coronary arteries. This is a standard test, which is commonly used to predict CHD risk but cannot distinguish calcium that has been there for some time from calcium that is actively building up.

The patients were also injected with two tracers, special molecules that show up on certain imaging scans and can be used to track substances in the body.

One of these tracers, 18F-sodium fluoride (18F-NaF), is a molecule taken up by cells in which active calcification is occurring. The 18F-NaF can then be picked up and measured on PET scans.

The researchers wanted to see if they could identify patients with active, ongoing calcification because these patients may be at higher risk than patients in whom the calcium developed a long time ago.

The results showed that increased 18F-NaF activity could be observed in specific coronary artery plaques in patients who had many other high-risk markers of cardiovascular disease.

Dr Marc Dweck, lead author on the research paper and a BHF Clinical Research Fellow at the University of Edinburgh, said:

"Predicting heart attacks is very difficult and the methods we've got now are good but not perfect. Our new technique holds a lot of promise as a means of improving heart attack prediction although further ongoing work is needed before it becomes routine clinical practice.

"If we can identify patients at high risk of a heart attack earlier, we can then use intensive drug treatments, and perhaps procedures such as stents, to reduce the chances of them having a heart attack."

Dr Shannon Amoils, Research Advisor at the (BHF), which funded the study, said:

"For decades cardiologists have been looking for ways to detect the high-risk plaques found in coronary arteries that could rupture to cause a heart attack, but it's been difficult to develop a suitable imaging test that can focus in on these small vessels.

"This research is a technical tour de force as it allows us to assess active calcification happening right in the problem area inside the wall of the coronary arteries and this active calcification may correlate with a higher risk of a heart attack."

The research follows on from recent work Dr Dweck did using PET/CT that provided greater insight into the aortic valve disease aortic stenosis (5). With the support of the BHF, Dr Dweck and his colleagues at Edinburgh also intend to translate this technique into predicting a patient's risk of a stroke.


'/>"/>
Contact: Ben Kolb
newsdesk@bhf.org.uk
44-207-554-0164
University of Edinburgh
Source:Eurekalert

Related biology technology :

1. Leading Scientists to Debate Views on Rejuvenation Biotechnologies
2. UCF scientists use nanotechnology to hunt for hidden pathogens
3. Scientists develop tools to make more complex biological machines from yeast
4. UMass Amherst polymer scientists, physicists develop new way to shape thin gel sheets
5. Scientists Discover How a Bacterial Pathogen Breaks Down Barriers to Enter and Infect Cells
6. Design eye for the science guy: Drop-in clinic helps scientists communicate data
7. Scientists learn how to out run damage with imaging technique
8. Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science
9. Scientists decode brain waves to eavesdrop on what we hear
10. Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research
11. iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking ... initiative announced today. The bold new look is part of a transformation to ... into a significant growth period. , It will also expand its service offering from ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation President ... and Astronomy, has been selected for membership in ARCS Alumni Hall of Fame ... Prize in Fundamental physics for the discovery of the accelerating expansion of the universe, ...
(Date:10/7/2017)... 6, 2017  The 2017 Nobel Prize in ... Jacques Dubochet, Joachim Frank and ... cryo-electron microscopy (cryo-EM) have helped to broaden ... biology community. The winners worked with systems manufactured ... produce highly resolved, three-dimensional images of protein structures ...
Breaking Biology Technology:
(Date:6/14/2017)... -- IBM (NYSE: IBM ) is introducing several innovative partner ... developing collaboration between startups and global businesses, taking place in ... event, nine startups will showcase the solutions they have built ... France is one of ... 30 percent increase in the number of startups created between ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):