SACHEM announced today the launch of a new displacement chromatography e-Learning program. With the growing popularity of SACHEM’s Isolis™ displacers, SACHEM is offering scientists worldwide the ability to learn more about applying displacement chromatography in two dimensional High Performance Liquid Chromatography (2-D HPLC).
AUSTIN, Texas (Business Wire EON) September 8, 2008 -- Two-dimensional HPLC facilitates the separation of complex mixtures by using different chromatography modes as sequential steps. By using displacement chromatography in the first dimension, one can better analyze and prove product purity through greater sensitivity and precision in identification of trace components. Moreover, in oligonucleotide, proteomics and other similar applications, this technique is a measurable superior technique to detect minor component biomolecules of interest. 2-D HPLC using displacement chromatography in the first dimension addresses challenges in characterization, process control, process optimization, biomarker analysis, QBD programs and proteomics.
This 10-minute, customized, simulation-based program enables users to gain a deeper understanding of 2-D HPLC using displacement chromatography. In the first dimension one uses displacement chromatography to concentrate low abundance materials in discrete transition zones within the displacement train. This first step removes 95% of main component interference without affinity resins or prior knowledge of component identity. The second chromatography step is then used to analyze these enriched samples.
"The results of 2-D HPLC with displacement chromatography are impressive and this new e-Learning course illustrates the power of integrating this method into critical analytical analysis," remarks Rosemary Hoffman, Director, Biotechnology Solutions Group at SACHEM. "Proof of product purity
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