Navigation Links
On the hunt for rare cancer cells
Date:11/12/2012

Tumor cells circulating in a patient's bloodstream can yield a great deal of information on how a tumor is responding to treatment and what drugs might be more effective against it. But first, these rare cells have to be captured and isolated from the many other cells found in a blood sample.

Many scientists are now working on microfluidic devices that can isolate circulating tumor cells (CTCs), but most of these have two major limitations: It takes too long to process a sufficient amount of blood, and there is no good way to extract cancer cells for analysis after their capture.

A new device from researchers at MIT and Brigham and Women's Hospital overcomes those obstacles. Inspired by the tentacles of a jellyfish, the team coated a microfluidic channel with long strands of DNA that grab specific proteins found on the surfaces of leukemia cells as they flow by. Using this strategy, the researchers achieved flow rates 10 times higher than existing devices fast enough to make the systems practical for clinical use.

Using this technology, described in this week's issue of the Proceedings of the National Academy of Sciences, doctors could monitor cancer patients to determine whether their treatment is working.

"If you had a rapid test that could tell you whether there are more or less of these cells over time, that would help to monitor the progression of therapy and progression of the disease," says Jeff Karp, an associate professor of medicine at Harvard Medical School and co-director of the Center for Regenerative Therapeutics at Brigham and Women's Hospital in Boston.

This type of device could also enable personalized treatments: Once cells are isolated from a patient, doctors could test different drugs on them to determine which are most effective.

The new technology grew out of a collaboration between Karp's lab and that of Rohit Karnik, an associate professor of mechanical engineering at MIT. Lea
'/>"/>

Contact: Kimberly Allen
allenkc@mit.edu
617-253-2702
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Novel Cancer Immune Therapy Developer Oncos Therapeutics Appoints Experienced Industry Leader Frans Wuite as President and CEO
2. VolitionRxs Preliminary Diagnostic Clinical Trial Results Show High Sensitivity and Specificity for Colon, Breast and Lung Cancers
3. Response Genetics, Inc. to Offer ROS1 Testing for Lung Cancer
4. Lung Cancer Survivors Share Stories of Value of Early Detection and Hope for More Effective Treatments
5. Multimodal Treatment of Peritoneal Metastases Offers Hope for Many Patients With Colorectal Cancer
6. Top Contenders For the First Annual 2012 Fright Night Awards Presented By Cancer Bites Announced
7. QIAGEN and Bayer HealthCare Partner to Develop Companion Diagnostics to Guide Treatment Decisions for Targeted Cancer Therapies
8. Can Cannabidiol (CBD) Fight Metastatic Cancer? According to the latest research the answer is yes.
9. Merrimack Pharmaceuticals To Present Preliminary Clinical Data For Novel Therapies Targeting Molecular Pathways In Advanced Cancers
10. Genomic Health Announces Positive Topline Results of Large Prostate Cancer Clinical Validation Study; Company to Proceed with 2013 Commercial Launch
11. Pinnaclife Sponsors "The Prevent Event: Breast Cancer Education And You!"
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... PALO ALTO, Calif. , April 17, ... company, has received a SBIR grant from ... of the National Institutes of Health (NIH). ... ongoing research efforts in the development of ... complete genomes using specially fabricated substrates. Centrillion ...
(Date:4/17/2015)... 2015 Reed Technology and Information ... data management, preparation, and submission to the U.S. Food ... a new Lot Distribution Report (LDR) service for manufacturers ... compliant with the FDA’s new rule on electronic submission ... monitor the volume and timing of particular biologics introduced ...
(Date:4/17/2015)... 17, 2015 CIO Review ( http://www.cioreview.com ... 20 Most Promising Pharma and Life Science Technology Solution ... global compliance software platform for life sciences companies. ... a panel of experts and members of CIO Review’s ... MediSpend Platform has been on our radar for some ...
(Date:4/17/2015)... April 17, 2015 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: ... company that develops and commercializes proprietary technologies and ... that it has received approval from the TSX ... outstanding common share purchase warrants ("the Warrants") of ... the Company,s May 2013 private placement financing. ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2SQI Diagnostics to Extend Warrant Expiry 2SQI Diagnostics to Extend Warrant Expiry 3
... SyntheMed, Inc. (OTC,Bulletin Board: SYMD), a biomaterials ... drug delivery products and other,surgical implants, announced today ... 2008 MedTech conference being held in Washington, D.C. ... CEO of SyntheMed, is scheduled,to present on Wednesday, ...
... Keck Graduate Institute,(KGI) today announced that it will ... the latest developments in mammalian cell culture,from November ... explosive growth over the,last 25 years," said Matt ... and director of the Amgen Bioprocessing Center at ...
... results of implant operations., SAN CLEMENTE, Calif., ... to orthopedic surgeons being able to immediately gauge ... LifeModeler, Inc.,The company, a leading global provider of ... $400,000 of software and,services to InMotion Musculoskeletal Institute ...
Cached Biology Technology:SyntheMed To Present at the AdvaMed 2008 MedTech Conference 2KGI Offers Mammalian Cell Culture Program for Biotech Industry Professionals 2LifeModeler, Inc. Provides $400,000 Grant to InMotion Musculoskeletal Institute 2
(Date:4/17/2015)... , April 17, 2015 ... security concerns, and technological advancement to drive biometric ... until 2020   According to ... Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market ... projected to register growth at CAGR of over ...
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... nominated for the 2015 New York Design Awards under ... Design100, New York City Design Awards are part of ... on over 2,500 ratings from the marketplace, industry and ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... I'd like to see how they calculated that, and their standard ... yet! Still, if it's a real trend, it could be alarming. ... change its pH, I guess! , A report issued by ... world's oceans. "If CO2 from human activities continues to rise, the ...
... from a study on a promising new vaccine against ... cervical pre-cancers and non-invasive cervical cancer, according to a ... Research's 4th Annual Frontiers in Cancer Prevention Research meeting ... phase III study, originally published in early October, confirmed ...
... Science University researchers have identified some of the key ... by multiple sclerosis (MS), complications of premature birth, and ... about why the nervous system fails to repair itself ... brain damage could be reversed. The research is published ...
Cached Biology News:Oceans turning to acid from rise in CO2 2Updated data on novel HPV vaccine confirms efficacy in large population 2Molecular Partners Required For Appropriate Neuronal Gene Repression 2Molecular Partners Required For Appropriate Neuronal Gene Repression 3Molecular Partners Required For Appropriate Neuronal Gene Repression 4
Mouse monoclonal [164-12-2] to Ampicillin ( Abpromise for all tested applications)....
Flotillin-2 (ESA) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 29, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
... Rabbit polyclonal to Kv4.2 Immunogen ... KLH, corresponding to amino acids 23-43 of ... Cross-reacts with Rat.Expected to cross-react with Human ... with immunogen), Rabbit (100% identity with immunogen) ...
Human Presenilin-2 NTF Affinity Purified Polyclonal Ab...
Biology Products: