Navigation Links
Ubiquitin/Proteasome Fraction II Extract from GeneTex

ProductsUbiquitin/Proteasome Fraction II Extract from GeneTex
Company GeneTex
Item Ubiquitin/Proteasome Fraction II Extract
Price $380.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80878 is the protein fraction of cell extract that binds to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80878 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s), ubiquitin C-terminal hydrolases (UCHs) and the 20S and 26S proteasomes. GTX80878 is ideal for demonstrating ubiquitin and/or ATP dependent degradation of in vitro substrates.

  • Type: Proteins and peptides
  • Form: 11.0 mg/ml protein from rabbit reticulocytes in 25 mM HEPES, pH 7.6.
Info GeneTexGeneTex
14785 Omicron Dr. Suite101
San Antonio, TX 78245
Customer Service: (877) 436-3839
Fax Number: (210) 677-8843
Web Site: http://www.genetex.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. ProteomeLab PF 2D Protein Fractionation System from Beckman Coulter
2. UBC Fractions Extract from GeneTex
3. 26S Proteasome Fraction Extract from GeneTex
4. Ubiquitin Fraction I from ABR-Affinity BioReagents
5. 26S Proteasome Fraction Extract from GeneTex
6. Ubiquitin Fraction I Extract from GeneTex
7. FractionPREP Cell Fractionation Kit from BioVision
8. cDNA Size Fractionation Columns from Invitrogen
9. ZOOM® IEF Fractionator from Invitrogen
10. Nuclear / Cytosol Fractionation Kit from MBL International
11. Mitochondria / Cytosol Fractionation Kit from MBL International
The PDS-1000 He Hepta system includes the PDS-1000 He biolistic system and the Hepta adaptor....
... He system uses a burst of ... nucleic acid-coated gold or tungsten microparticles ... tissues, or organelles without dependence or ... system includes helium pressure regulator, solenoid, ...
... LP system, 220-240 V, is used ... collection. The system includes the BioLogic ... with MV-6 injection valve, proportioning valve ... tubing and fittings kit, column and ...
Sf21 Insect Cells (Frozen) in Max-XP Medium...
Biology Products:
(Date:11/29/2016)... 2016 BioDirection, a privately held medical device ... objective detection of concussion and other traumatic brain injury ... a meeting with the U.S. Food and Drug Administration ... Package. During the meeting company representatives reviewed plans for ... to commencement of a planned pilot trial. ...
(Date:11/22/2016)... -- According to the new market research report "Biometric System ... Voice), Multi-Factor), Component (Hardware and Software), Function (Contact and Non-contact), Application, and ... expected to grow from USD 10.74 Billion in 2015 to reach USD ... 2022. Continue Reading ... ...
(Date:11/17/2016)...  AIC announces that it has just released a new white paper authored by ... plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system can ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... 5, 2016 NxGen MDx announced today that it brought its ... house, we,ve been able to improve customer service through shortened turnaround times ... Alan Mack , CEO of NxGen MDx. ... , A decrease in turnaround ... to more job opportunities at the Grand Rapid headquarters. The ...
(Date:12/5/2016)... -- Research and Markets has announced the addition ... Markets and Companies" to their offering. ... , , ... genome variations, development of sequencing technologies, and their applications. Current ... developing them. Various applications of sequencing are described including those ...
(Date:12/4/2016)... ... December 02, 2016 , ... A proposed five-year extension for ... funded research and development is welcome news for the photonics community, say leaders ... As part of the National Defense Authorization Act (NDAA) compromise agreement finalized today ...
(Date:12/4/2016)... 2016  In five studies being presented today during ... and Exposition in San Diego , ... the delivery of life-saving treatments to patients with a ... to carry therapies directly to the sites in the ... a substantial advantage over traditional, systemic methods. The studies ...
Breaking Biology Technology: