Navigation Links
Ubiquitin Fraction I from ABR-Affinity BioReagents

ProductsUbiquitin Fraction I from ABR-Affinity BioReagents
Company ABR-Affinity BioReagents
Item Ubiquitin Fraction I
Price $355.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome.

EP-500 is the protein fraction of HeLa cell extract that does not bind to anion exchange resin. EP-500 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). EP-500 is ideal for demonstrating if FI enzymes are critical for degradation of in vitro substrates as well as in vitro conjugation activity.

Info ABR-Affinity BioReagentsABR-Affinity BioReagents
ABR-Affinity BioReagents Inc.
4620 Technology Drive, Suite 600
Golden, CO 80403
USA

Customer Service: +1.800.527.4535
Fax Number: +1.303.278.2424
Web Site: http://www.bioreagents.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Ubiquitin/Proteasome Fraction II Extract from GeneTex
2. Ubiquitin Fraction I Extract from GeneTex
3. Mouse Anti-Ubiquitin, Multi Monoclonal Antibody, Unconjugated, Clone FK2 from Assay Designs/Stressgen Bioreagents
4. Ubiquitin Related I Sampler Kit from BD Biosciences Pharmingen
5. Rabbit Anti-Human Ubiquitin-conjugating enzyme E2N Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.
6. ProteomeLab PF 2D Protein Fractionation System from Beckman Coulter
7. UBC Fractions Extract from GeneTex
8. 26S Proteasome Fraction Extract from GeneTex
9. 26S Proteasome Fraction Extract from GeneTex
10. FractionPREP Cell Fractionation Kit from BioVision
11. cDNA Size Fractionation Columns from Invitrogen
with GlutaMAXIL-glutamine...
This STAT antibody sampler pack contains 8 monoclonal ,STAT antibodies....
Kanamycin is used for selection of resistant bacteria. C18H36N4O11xH2SO4. Contains 10 mg/ml kanamycin (base) utilizing kanamycin sulfate in 0.85% saline....
...
Biology Products:
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Resoundant, Inc. is pleased ... centers around the U.S. that offer MR Elastography for liver fibrosis staging. ... biopsy for staging liver fibrosis assessment. , “MRE:connect was created in response to ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... digital pathology and artificial intelligence Tuesday, July 25, during the Association of Pathology ... Johns Hopkins Medicine. , Baras, Associate Director of Pathology Informatics, will present ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... accelerate pharmaceutical and biotherapeutics development, announces the launch of a new NTA biosensor ... chip enables researchers to study the kinetics of polyhistidine-tagged (His-tagged) molecules quickly and ...
(Date:7/18/2017)... ... ... Blood centers traditionally see a dangerous drop of blood donations during the ... community blood centers as high schools are out and many frequent donors are on ... up with the South Texas Blood & Tissue Center (STBTC), a subsidiary ...
Breaking Biology Technology: