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Rabbit Anti-Human PHAS-II Polyclonal Antibody, Unconjugated from Lab Vision

ProductsRabbit Anti-Human PHAS-II Polyclonal Antibody, Unconjugated from Lab Vision
Company Lab Vision
Item Rabbit Anti-Human PHAS-II Polyclonal Antibody, Unconjugated
Price $269.00
Description PHAS-II (eIF4E-binding protein II) is involved in translation initiation. PHAS-II is highest in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA in vitro and in cells. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation initiation. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II. Thus, PHAS proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.
Antigen: A synthetic peptide aa 99-120 from human PHAS-II.
Info Lab VisionLab Vision
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Fremont, CA 94539
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