Rabbit Anti-Human MMP-14 / MT1-MMP Antibody, Unconjugated from Lab Vision

Products	Rabbit Anti-Human MMP-14 / MT1-MMP Antibody, Unconjugated from Lab Vision
Company	Lab Vision
Item	Rabbit Anti-Human MMP-14 / MT1-MMP Antibody, Unconjugated
Price	$349.00
Description	MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form. Antigen: A synthetic peptide derived from aa 160-173 of human MMP-14 protein. This antibody is excellent for staining of formalin-fixed, paraffin-embedded tissues.
Info	Lab Vision 47777 Warm Springs Blvd. Fremont, CA 94539 Customer Service: 800-828-1628 Fax Number: 510-991-2826 Web Site: http://www.labvision.com

NOTE: Price information is approximate list price and actual prices may vary.

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