|Products||Rabbit Anti-Human MMP-14 / MT1-MMP Antibody, Unconjugated from Lab Vision|
|Item||Rabbit Anti-Human MMP-14 / MT1-MMP Antibody, Unconjugated|
|Description|| MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2 forming a trimer. It cleaves the pro-MMP-2 to its active form. |
Antigen: A synthetic peptide derived from aa 160-173 of human MMP-14 protein.
This antibody is excellent for staining of formalin-fixed, paraffin-embedded tissues.
|Info|| Lab Vision|
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