Navigation Links
Qpatch HT from Sophion Bioscience

ProductsQpatch HT from Sophion Bioscience
Company Sophion Bioscience
Item Qpatch HT
Price Inquire
Description Sophions newly introduced QPatch HT is taking automated patch clamping to a new and even more powerful level. With its ability to generate thousands of high quality data points daily, QPatch HT is enabling new screening paradigms in ion channel drug discovery and safety testing. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. This can be expected to further fuel the revolution in ion channel drug discovery and safety testing.

The QPatch HT is a 48-channel gigaseal patch clamp system that can be applied to both voltage-gated and ligand-gated ion channels. The system includes 48 individual low-noise patch clamp amplifiers and pressure controllers. Independent pressure control (i.e. suction on each cell individually) is important because each cell performs uniquely. Gigaseals and/or whole cells are obtained with some cells quickly while with other cells more slowly.

The QPatch HT has eight pipettes attached to the fluid handling robot to keep pace with the liquid handling demand of up to 48 simultaneous patch clamp experiments. For comparison the QPatch 16 has four pipettes. To further optimize system performance, an intelligent, forward-looking strategy for allocation of the pipettes to the actual liquid application tasks has been implemented in the QPatch HT. Especially for ligand-gated ion channel applications the eight intelligently moving pipettes are leading to a significantly increased throughput compared to todays automated patch clamp systems.

The 48-channel QPlate measurement plate builds on the same technology as the original 16-channel QPlate. The individual measurement sites include glass-coated microfluidic channels for less compound absorption and hence more accurate IC50-values. The microfluidic channels require only small volumes of liquid for each experiment (approximately 5 l) and enable cumulative dose-response experiments or screening of multiple compounds on the same cell. The liquid exchange time is ~ 100 ms.

The unique automated cell preparation station is also a popular feature from the QPatch 16. It keeps the cells in suspension until the experiment begins. Prior to application to the QPlate, cells are transferred to the on-board centrifuge where they are spun down and resuspended in the extracellular ringer solution to a concentration that ensures optimal success rates. Elevator units for stacking and feeding compound plates and QPlates are featured in the QPatch HT. Together with the cell preparation station, the elevator units ensure more than four hours of unattended operation with the QPatch HT. This, for instance, means that the system can be put to work after normal working hours, thus enhancing daily throughput.

While automated patch clamping has lead to significantly increased data throughput, a new bottleneck of data analysis has emerged in the horizon. The new QPatch Assay Software offers elegant automated data analysis features to efficiently remove that bottleneck.

Info Sophion BioscienceSophion Bioscience
Sophion Bioscience, Inc. (USA Office)
P.O. Box 83
Annandale, NJ 08801 USA

Sophion Bioscience A/S
Baltorpvej 154
DK-2750 Ballerup
Denmark


Customer Service: (908) 638-6589
Fax Number: (908) 638-6374
Web Site: http://www.sophion.dk
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. QPatch 16 from Sophion Bioscience
2. Qplate from Sophion Bioscience
3. Mouse Anti-Mouse Glutathione S-transferase M1 (GSTM1) Monoclonal Antibody, Unconjugated from Lifespan Biosciences
4. Rabbit Anti-Human Vitamin K-dependent Protein S (PROS1) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
5. Rabbit Anti-Human Sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7 (SIRT7) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
6. BD Pathway 435 confocal bioimager from BD Biosciences - Bioimaging
7. Hybridoma Development from QED Bioscience Inc.
8. Random DNA mutagenesis Service from Yorkshire Bioscience Ltd
9. BD Pathway 415 bioimager from BD Biosciences - Bioimaging
10. SphingoBeads from Echelon Biosciences Inc.
11. BD Falcon Roller Bottle, smooth surface from BD Biosciences - Discovery Labware
(Date:9/30/2014)... Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich report that ... cells more sensitive to chemotherapeutic drugs. They have ... a new target for anti-tumor agents. , ... Professor Stephan Sieber of the Technische Universitt Mnchen ... a potential new weapon in the fight against ...
(Date:9/30/2014)... 30, 2014  Spectra Automation, a trusted ... biotech and power generation industries, announced today ... Manager, an easy-to-use and cost-effective data collection, ... development laboratories. Most upstream ... analyzer systems. Accessing and consolidating data from ...
(Date:9/29/2014)... Clostridium ramosum , coupled with a high-fat diet, may cause ... in mBio , the online open-access journal of the ... the German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed ... gained weight when fed a high-fat diet. Mice that ... even when consuming a high-fat diet, and mice that had ...
Breaking Biology News(10 mins):Cancer therapy: Driving cancer cells to suicide 2Spectra Automation Introduces RECONN Bioprocess Manager 2Gut bacteria promote obesity in mice 2
... Leadership Strengthened with Clinical ... Standards-Based Data Management, WHIPPANY, N.J. and ATLANTA, ... it agreed to terms to acquire Zurich,Biostatistics, Inc. ... regulatory submissions, the acquisition further strengthens,ISI,s Clinical Data ...
... SHORES, Calif., Sept. 10 ,Communication Intelligence Corporation (OTC ... signature solutions for business process,automation in the financial ... announced today the appointment of Michael Betts to,the ... over 30 years of experience in the insurance ...
... J. Michael McConnell, Director of,National Intelligence and ... Intelligence will provide valuable insights into the intelligence,challenges ... the United States,Intelligence Community 100 Day Plan for ... The Office of the Director of National Intelligence ...
Cached Biology News:Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 2Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 3Michael A. Betts, Seasoned Financial Services Executive, Joins CIC Board of Directors 2Michael A. Betts, Seasoned Financial Services Executive, Joins CIC Board of Directors 3
(Date:10/1/2014)... The participants committed to not only creating ... own time adjusting, tweaking and testing virtual models and ... for judging. , “I enjoyed being involved as a ... “The entries showed a commendable range exploring the technical ... print medium and the creativity of the contestants.” , ...
(Date:10/1/2014)... 2014 In response to its ... address sales, training and consumer engagement challenges, ... mobile applications to turn their clients’ visions into ... customized mobile app creations, are now featured on ... partnership with Toyota, StudioPMG created a robust cross-platform ...
(Date:10/1/2014)... 30, 2014 Award winning unified ... announces four new-hosted collaboration bundles that combine next ... quality conferencing experiences for low, flat rate fees. ... from, businesses have optimized solutions to meet their ... include audio only minutes (1K, 5K, 10K increments) ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 TeselaGen ... National Science Foundation to expand their bioCAD/CAM software suite, ... and modify DNA. The Small Business Innovation Research Phase ... “j5” technology under exclusive license from the Lawrence Berkeley ... BioEnergy Institute , an LBNL laboratory that develops alternative ...
Breaking Biology Technology:Array Architects Challenges Staff to Create with 3D Printer 2Digital Agency Studio PMG Launches New Case Studies on Website 2SoundConnect Launches New Audio, Web and Video Bundles 2TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3