Navigation Links
Qpatch HT from Sophion Bioscience

ProductsQpatch HT from Sophion Bioscience
Company Sophion Bioscience
Item Qpatch HT
Price Inquire
Description Sophions newly introduced QPatch HT is taking automated patch clamping to a new and even more powerful level. With its ability to generate thousands of high quality data points daily, QPatch HT is enabling new screening paradigms in ion channel drug discovery and safety testing. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. This can be expected to further fuel the revolution in ion channel drug discovery and safety testing.

The QPatch HT is a 48-channel gigaseal patch clamp system that can be applied to both voltage-gated and ligand-gated ion channels. The system includes 48 individual low-noise patch clamp amplifiers and pressure controllers. Independent pressure control (i.e. suction on each cell individually) is important because each cell performs uniquely. Gigaseals and/or whole cells are obtained with some cells quickly while with other cells more slowly.

The QPatch HT has eight pipettes attached to the fluid handling robot to keep pace with the liquid handling demand of up to 48 simultaneous patch clamp experiments. For comparison the QPatch 16 has four pipettes. To further optimize system performance, an intelligent, forward-looking strategy for allocation of the pipettes to the actual liquid application tasks has been implemented in the QPatch HT. Especially for ligand-gated ion channel applications the eight intelligently moving pipettes are leading to a significantly increased throughput compared to todays automated patch clamp systems.

The 48-channel QPlate measurement plate builds on the same technology as the original 16-channel QPlate. The individual measurement sites include glass-coated microfluidic channels for less compound absorption and hence more accurate IC50-values. The microfluidic channels require only small volumes of liquid for each experiment (approximately 5 l) and enable cumulative dose-response experiments or screening of multiple compounds on the same cell. The liquid exchange time is ~ 100 ms.

The unique automated cell preparation station is also a popular feature from the QPatch 16. It keeps the cells in suspension until the experiment begins. Prior to application to the QPlate, cells are transferred to the on-board centrifuge where they are spun down and resuspended in the extracellular ringer solution to a concentration that ensures optimal success rates. Elevator units for stacking and feeding compound plates and QPlates are featured in the QPatch HT. Together with the cell preparation station, the elevator units ensure more than four hours of unattended operation with the QPatch HT. This, for instance, means that the system can be put to work after normal working hours, thus enhancing daily throughput.

While automated patch clamping has lead to significantly increased data throughput, a new bottleneck of data analysis has emerged in the horizon. The new QPatch Assay Software offers elegant automated data analysis features to efficiently remove that bottleneck.

Info Sophion BioscienceSophion Bioscience
Sophion Bioscience, Inc. (USA Office)
P.O. Box 83
Annandale, NJ 08801 USA

Sophion Bioscience A/S
Baltorpvej 154
DK-2750 Ballerup
Denmark


Customer Service: (908) 638-6589
Fax Number: (908) 638-6374
Web Site: http://www.sophion.dk
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. QPatch 16 from Sophion Bioscience
2. Qplate from Sophion Bioscience
3. Mouse Anti-Mouse Glutathione S-transferase M1 (GSTM1) Monoclonal Antibody, Unconjugated from Lifespan Biosciences
4. Rabbit Anti-Human Vitamin K-dependent Protein S (PROS1) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
5. Rabbit Anti-Human Sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7 (SIRT7) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
6. BD Pathway 435 confocal bioimager from BD Biosciences - Bioimaging
7. Hybridoma Development from QED Bioscience Inc.
8. Random DNA mutagenesis Service from Yorkshire Bioscience Ltd
9. BD Pathway 415 bioimager from BD Biosciences - Bioimaging
10. SphingoBeads from Echelon Biosciences Inc.
11. BD Falcon Roller Bottle, smooth surface from BD Biosciences - Discovery Labware
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Narrow-mouth has heavy-duty rim. Approximate graduations are in durable white enamel. Extra large marking space. capacity 125 mL Special grade: student grade...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
Certified by the Biological Stain Commission. For staining fresh peripheral blood smears and blood parasites....
Biology Products:
(Date:4/15/2014)... University of Missouri researchers have previously shown that a ... exercise exists. In a new study, Frank Booth, a ... found a potential link between the genetic pre-disposition for ... which mental maturation occurs. , For his study, Booth ... activity or extreme laziness. Booth then put the rats ...
(Date:4/15/2014)... drew a line as it chased its next meal, ... there,s method to that mess, says Jane Wang, a ... tries to find simple physical explanations for complex, hardwired ... turns out the tiger beetle, known for its speed ... chases its prey at blinding speeds. Publishing online April ...
(Date:4/15/2014)... has developed over the course of evolution, scientists from ... insights from the study of earwigs. "Young earwig offspring ... what is available amongst themselves, especially when the mother ... Biology section of the Institute of Zoology at Johannes ... from Mainz University and the University of Basel investigated ...
Breaking Biology News(10 mins):Genetic pre-disposition toward exercise and mental development may be linked 2Photo: Tiger beetle's chase highlights mechanical law 2Sibling cooperation in earwig families gives clues to early evolution of social behavior 2
... - Wheat plants found to be resistant to Hessian ... up rigid defenses. Christie Williams, a research scientist ... and a Purdue University associate professor of entomology, found ... increased production of surface waxes and cutin, a molecule ...
... GALVESTON, Texas Why do people become physically weaker ... stop, or even reverse this process, breaking the link between ... online this Wednesday in the Journal of Clinical Endocrinology ... researchers present evidence that answers to both those questions can ...
... MN Bringing the power of synchrotron light to ... aim of a Memorandum of Agreement (MOA) signed today ... national synchrotron facility, the Canadian Light Source (CLS). ... scientific and product outcomes while improving operating efficiency for ...
Cached Biology News:Resistant wheat rebuilds cell walls when attacked by Hessian flies 2Muscle loss in elderly linked to blood vessels' failure to dilate 2BioBusiness Alliance, Canadian Light Source Synchrotron sign agreement 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2