Navigation Links
Qpatch HT from Sophion Bioscience

ProductsQpatch HT from Sophion Bioscience
Company Sophion Bioscience
Item Qpatch HT
Price Inquire
Description Sophions newly introduced QPatch HT is taking automated patch clamping to a new and even more powerful level. With its ability to generate thousands of high quality data points daily, QPatch HT is enabling new screening paradigms in ion channel drug discovery and safety testing. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. This can be expected to further fuel the revolution in ion channel drug discovery and safety testing.

The QPatch HT is a 48-channel gigaseal patch clamp system that can be applied to both voltage-gated and ligand-gated ion channels. The system includes 48 individual low-noise patch clamp amplifiers and pressure controllers. Independent pressure control (i.e. suction on each cell individually) is important because each cell performs uniquely. Gigaseals and/or whole cells are obtained with some cells quickly while with other cells more slowly.

The QPatch HT has eight pipettes attached to the fluid handling robot to keep pace with the liquid handling demand of up to 48 simultaneous patch clamp experiments. For comparison the QPatch 16 has four pipettes. To further optimize system performance, an intelligent, forward-looking strategy for allocation of the pipettes to the actual liquid application tasks has been implemented in the QPatch HT. Especially for ligand-gated ion channel applications the eight intelligently moving pipettes are leading to a significantly increased throughput compared to todays automated patch clamp systems.

The 48-channel QPlate measurement plate builds on the same technology as the original 16-channel QPlate. The individual measurement sites include glass-coated microfluidic channels for less compound absorption and hence more accurate IC50-values. The microfluidic channels require only small volumes of liquid for each experiment (approximately 5 l) and enable cumulative dose-response experiments or screening of multiple compounds on the same cell. The liquid exchange time is ~ 100 ms.

The unique automated cell preparation station is also a popular feature from the QPatch 16. It keeps the cells in suspension until the experiment begins. Prior to application to the QPlate, cells are transferred to the on-board centrifuge where they are spun down and resuspended in the extracellular ringer solution to a concentration that ensures optimal success rates. Elevator units for stacking and feeding compound plates and QPlates are featured in the QPatch HT. Together with the cell preparation station, the elevator units ensure more than four hours of unattended operation with the QPatch HT. This, for instance, means that the system can be put to work after normal working hours, thus enhancing daily throughput.

While automated patch clamping has lead to significantly increased data throughput, a new bottleneck of data analysis has emerged in the horizon. The new QPatch Assay Software offers elegant automated data analysis features to efficiently remove that bottleneck.

Info Sophion BioscienceSophion Bioscience
Sophion Bioscience, Inc. (USA Office)
P.O. Box 83
Annandale, NJ 08801 USA

Sophion Bioscience A/S
Baltorpvej 154
DK-2750 Ballerup
Denmark


Customer Service: (908) 638-6589
Fax Number: (908) 638-6374
Web Site: http://www.sophion.dk
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. QPatch 16 from Sophion Bioscience
2. Qplate from Sophion Bioscience
3. Mouse Anti-Mouse Glutathione S-transferase M1 (GSTM1) Monoclonal Antibody, Unconjugated from Lifespan Biosciences
4. Rabbit Anti-Human Vitamin K-dependent Protein S (PROS1) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
5. Rabbit Anti-Human Sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7 (SIRT7) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
6. BD Pathway 435 confocal bioimager from BD Biosciences - Bioimaging
7. Hybridoma Development from QED Bioscience Inc.
8. Random DNA mutagenesis Service from Yorkshire Bioscience Ltd
9. BD Pathway 415 bioimager from BD Biosciences - Bioimaging
10. SphingoBeads from Echelon Biosciences Inc.
11. BD Falcon Roller Bottle, smooth surface from BD Biosciences - Discovery Labware
Preadipocyte factor-1 [Pref-1, DLK-1], C-terminal...
Human SPARC-like 1 Biotinylated Affinity Purified PAb...
... PGE2-d4 contains 4 deuterium atoms at the ... is intended for use as an internal ... (PGE2) by GC- or LC-mass spectrometry. PGE2 ... of arachidonic acid and one of the ...
Request Info...
Biology Products:
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Alex,s Lemonade Stand Foundation (ALSF), a ... will open a state-of-the-art bioinformatics lab, using ,big data, ... announcement comes as Liz Scott , co-executive director ... Moonshot Summit in Washington, D.C. , ... participant and advocate of pediatric cancer research and awareness. ...
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: ... been advised by its major shareholders, Clean Technology Fund ... United States based venture capital funds ... of Biorem (on a fully diluted, as converted basis), ... disposition of their entire equity holdings in Biorem to ...
(Date:6/27/2016)...  Sequenom, Inc. (NASDAQ: SQNM ), a ... the development of innovative products and services, announced today ... States denied its petition to review decisions ... U.S. Patent No. 6,258,540 (",540 Patent") are not patent ... Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories decision.  ...
Breaking Biology Technology: