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Prostaglandin E1-d4 from Cayman Chemical

ProductsProstaglandin E1-d4 from Cayman Chemical
Company Cayman Chemical
Item Prostaglandin E1-d4
Price $41.00
Description PGE1-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM. The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival. In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1000 µg.
Info Cayman ChemicalCayman Chemical
Cayman Chemical Company
1180 East Ellsworth Road
Ann Arbor, Michigan 48108
Customer Service: (800) 364-9897
Fax Number: (734) 971-3640
Web Site: http://www.caymanchem.com/
NOTE: Price information is approximate list price and actual prices may vary.

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