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Phosphodiesterase I from USB Corp.

ProductsPhosphodiesterase I from USB Corp.
Company USB Corp.
Item Phosphodiesterase I
Description Source: Crotalus adamanteus venom
Phosphodiesterase I (venom exonuclease) is widely used in studying nucleic acid structure and sequence(1). It hydrolyzes 5'-mononucleotides from 3'-hydroxy-terminated ribo-oligonucleotides and deoxyribo-oligonucleotides(2). Phosphodiesterase I cleaves ADP-ribosylated proteins at the pyrophosphate linkages to yield phosphoribosyl-AMP(3).
Molecular Weight: 115,000 Da
Optimum pH: 9.8 - 10.4
Activators: Mg2+
Inhibitors: 5mM EDTA, reducing agents (gluthathione, cysteine and ascorbic acid), partial
inhibition by ATP, ADP and AMP
Lyophilized powder
Partially purified by the method of Bjrk(4) and treated to remove contaminating
5' nucleotidase(5).

Shipping and Storage:
Shipped on dry ice. Store at -20C.
Unit Definition:
One unit hydrolyzes 1M p-nitrophenyl thymidine-5-phosphate per min at 25C, pH 8.9.
greater than or equal to 20 units/mg

*Base composition and nearest neighbor analysis(1).
*Removal of cyclic AMP from protein preparations.


*HO, N. W. AND GILHAM, P. T. (1973) Biochem. Biophys. Acta, 308, 53-58.

*LASKOWSKI, M. (1971) in The Enzymes, 3rd Ed. (Academic Press, New York) IV, 313-328.

*HAYAISHI, O. (1976) Trends Biochem. Sci. 1, 9.

*BJRK, W., (1963) J. Biol. Chem. 238, 2487.

*SULKOWSKI, E. AND LASKOWSKI, M. (1971) Biochem. Biophys. Acta, 240, 443.

Info USB Corp.USB Corp.
26111 Miles Road
Cleveland Ohio 44128

Call USB Corp. to buy products (US and Canada only; other locations use numbers below)
USA Canada 1-216-245-1829
Customer Service: 216.765.5000
Fax Number: 216.464.5075
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