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PTP1B Inhibitor from Calbiochem

ProductsPTP1B Inhibitor from Calbiochem
Company Calbiochem
Item PTP1B Inhibitor
Price $170.00
Description 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable sulfanamido-benzbromarone compound that acts as a selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 μM and 8 μM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Purity: ≥95% by HPLC. Soluble in DMSO or EtOH. M.W. 741.5.

References: Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.

Info CalbiochemCalbiochem
Calbiochem, A Brand of EMD Biosciences, Inc.
10394 Pacific Center Court
San Diego, CA 92121
USA

Customer Service:
(800) 854-3417
(858) 450 9600

Tech Support: 800-628-8470
Fax Number:
(800) 776-0999
(858) 453 3552

Web Site: http://www.calbiochem.com
NOTE: Price information is approximate list price and actual prices may vary.

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