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PARP Inhibitor XI, DR2313 from Calbiochem

ProductsPARP Inhibitor XI, DR2313 from Calbiochem
Company Calbiochem
Item PARP Inhibitor XI, DR2313
Price $120.00
Description 

2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A brain-permeable and water soluble pyrimidinone compound that acts as a potent and NAD+-competitive inhibitor of PARP (IC50 = 200 nM and 240 nM for rhPARP1 and rmPARP2, respectively) with little activity against the dehydrogenase activity of GAPDH, ADH, LDH, or the ADP-ribosylase activity of bacterial diphtheria toxin even at concentrations as high as 10 µM. Shown to inhibit H2O2-induced PAR formation and neuronal cell death in primary rat cerebral cortex culture in vitro (EC50 = 270 nM) and exhibit neuroprotective effects in both permanent and transient focal ischemia models in rat in in vivo. Purity: ≥98% by HPLC. Soluble in H2O. CAS 284028-90-6, M.W. 182.2.

Info CalbiochemCalbiochem
Calbiochem, A Brand of EMD Biosciences, Inc.
10394 Pacific Center Court
San Diego, CA 92121
USA

Customer Service:
(800) 854-3417
(858) 450 9600

Tech Support: 800-628-8470
Fax Number:
(800) 776-0999
(858) 453 3552

Web Site: http://www.calbiochem.com
NOTE: Price information is approximate list price and actual prices may vary.

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