Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

Products	Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision
Company	Lab Vision
Item	Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02
Price	$469.00
Description	The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14^ARF^ arrests the cell cycle in a p53-dependent manner. p14^ARF^ binds to mdm2 and promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Beta-encoded N-terminal domain of p14^ARF^ and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways. Epitope: N-terminal Molecular Weight:14kDa Immunogen: Recombinant p14^ARF^ protein. Cellular localization:Nuclear
Info	Lab Vision 47777 Warm Springs Blvd. Fremont, CA 94539 Customer Service: 800-828-1628 Fax Number: 510-991-2826 Web Site: http://www.labvision.com

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