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Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

ProductsMouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision
Company Lab Vision
Item Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02
Price $469.00
Description The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14^ARF^ arrests the cell cycle in a p53-dependent manner. p14^ARF^ binds to mdm2 and promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Beta-encoded N-terminal domain of p14^ARF^ and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways.

Epitope: N-terminal

Molecular Weight:14kDa

Immunogen: Recombinant p14^ARF^ protein.

Cellular localization:Nuclear

Info Lab VisionLab Vision
47777 Warm Springs Blvd.
Fremont, CA 94539
Customer Service: 800-828-1628
Fax Number: 510-991-2826
Web Site: http://www.labvision.com
NOTE: Price information is approximate list price and actual prices may vary.

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