|Products||Mouse Anti-Presenilin 2 Monoclonal Antibody, Unconjugated, Clone APS 26 from GeneTex|
|Item||Mouse Anti-Presenilin 2 Monoclonal Antibody, Unconjugated, Clone APS 26|
|Description|| Mouse monoclonal [APS 26] to Presenilin 2|
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
Immunogen: Synthetic peptide: CLPYDPEMEEDSYDSFGEP, corresponding to amino acids 317-334 of Human Presenilin 2 with N-terminally added cysteine.
Specificity: No cross-reactivity is seen with presenilin 1.
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