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Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex

ProductsMouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex
Company GeneTex
Item Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17
Price $200.00
Description Mouse monoclonal [RS17 ] to PRKAR2

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

Immunogen: Purified regulatory subunit of cAMP-dependent protein kinase type II from bovine brain.

Specificity: Does not influence cAMP binding or holoenzyme formation.
Info GeneTexGeneTex
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