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Mouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4 from Lab Vision

ProductsMouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4 from Lab Vision
Company Lab Vision
Item Mouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4
Price $344.00
Description In normal tissues this enzyme exists predominantly as XDH which converts hypoxanthine and xanthine to uric acid, a critical plasma antioxidant. During ischemia, XDH is reversibly converted to the oxygen radical producing XO by oxidation of essential sulfhydryl groups or irreversibly through limited proteolytic cleavage of the amino-terminus. AO has a higher affinity for aldehydes than purines, but produces O in a manner very similar to XO because both oxidases possess nearly identical internal electron transport systems.

Epitope: C-terminal 358 amino acids

Molecular Weight:150kDa (a monomer of XDH) and 130kDa (AO and the proteolytically irreversibly modified XO)

Immunogen: C-terminal 358 amino acid fragment of human xanthine oxidase.

Cellular localization:Cytoplasmic

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