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Mouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4 from MitoScience LLC

ProductsMouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4 from MitoScience LLC
Company MitoScience LLC
Item Mouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4
Price $250.00
Description 100 g of monoclonal antibody reactive against the complex IV assembly factor SURF1. Cellular levels of SURF1 are highest in growing cultured cells. SURF1 is an important assembly factor for cytochrome c oxidase which is thought to participate in the folding of subunit II and parallel Cu2+ insertion into this subunit. Mutations of SURF1, particularly ones that result in an absence or near absence of the polypeptide, are the leading cause of cytochrome c oxidase deficiency. The anti-SURF1 mAb reacts specifically in human and bovine tissues. The levels of SURF1 are low even in rapidly dividing fibroblast cell cultures (as well as in mature tissues e.g. heart or liver). The low copy number is consistent with it acting to catalyze Complex IV assembly. In cells where cytochrome c oxidase assembly is incomplete because of mutations in genes for structural subunits of the enzyme SURF1 is significantly over-expressed. This is evident in Rho0 fibroblasts which are missing mtDNA and hence cannot synthesize subunits I, II and III of cytochrome c oxidase.
Info MitoScience LLCMitoScience LLC
1850 Millrace Drive
Suite 3A
Eugene, Oregon 97403
Customer Service: (800) 910-6486
Fax Number: (541) 284-1801
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