Navigation Links
Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex

ProductsMouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex
Company GeneTex
Item Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48
Price $295.00
Description Mouse monoclonal [HDAC8-48] to HDAC8

Regulation of gene expression is mediated by several mechanisms such as DNA methylation, ATP-dependent chromatin remodeling, and post translational modifications of histones, which include the dynamic acetylation and deacetylation of epsilon-amino groups of lysine residues present in the tail of core histones. The enzymes responsible for reversible acetylation/deacetylation processes are histone acetyltransferases(HATs) and histone deacetylases (HDACs), respectively. HATs act as transcriptional coactivators, and HDACs are part of transcriptional corepressor complexes. Mammalian HDACs can be divided into three classes according to sequence homology. Class I consists of the yeast Rpd3-like proteins (HDAC1, HDAC2, HDAC3, and HDAC8). Class II consists of the yeast Hda1-like proteins (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10). Class III comprises the yeast Sir2-like proteins. Class I HDACs are ubiquitously expressed, and most class II HDACs are tissue-specific. Class II HDACs have been implicated in the regulation of muscle differentiation. Interaction of HDAC4, 5, and 7 with members of the MEF2 family of transcription factors represses their transcriptional activity and prevents myogenesis. The deacetylase activity of class II HDACs is regulated by subcellular localization. The HDAC8 gene encodes for a 377 amino acid protein with a molecular weight of 43 kDa and is localized within the nucleus. HDAC8 mRNA is expressed in heart, lung, kidney, and pancreas as well as in several cell lines derived from cancer tissues.

Immunogen: Recombinant full length protein (Human).
Info GeneTexGeneTex
14785 Omicron Dr. Suite101
San Antonio, TX 78245
Customer Service: (877) 436-3839
Fax Number: (210) 677-8843
Web Site: http://www.genetex.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Mouse Anti-Amodiaquine Monoclonal Antibody, Unconjugated, Clone 6D10 from AntibodyShop A/S
2. Mouse Anti-Protein S Monoclonal Antibody, Unconjugated, Clone HYB 232-02 from Abcam
3. Mouse Anti-Mouse Glutathione S-transferase M1 (GSTM1) Monoclonal Antibody, Unconjugated from Lifespan Biosciences
4. Mouse Anti-Human S-100 alpha/beta chain Monoclonal Antibody, Unconjugated, Clone 8B10 from Santa Cruz Biotechnology, Inc.
5. Rapid-Screen Arrayed cDNA Library Panels Master Plates -Mouse Testis from OriGene Technologies
6. Rapid-Screen Arrayed cDNA Library Panels Master Plates -Mouse Brain (adult) from OriGene Technologies
7. Rapid-Screen Arrayed cDNA Library Panels Master Plates -Mouse Embryo (12.5 - day) from OriGene Technologies
8. Rapid-Screen Arrayed cDNA Library Panels Master Plates -Mouse Embryo (19 - day) from OriGene Technologies
9. Rapid-Screen Arrayed cDNA Library Panels Master Plates -Mouse Thymus from OriGene Technologies
10. Mouse Anti-Human Complement factor B Monoclonal Antibody, Unconjugated, Clone 9B6 from AntibodyShop A/S
11. Mouse Anti-Human Choriongonadotropin (hCG) Monoclonal Antibody, Unconjugated, Clone 5F10 from AntibodyShop A/S
...e/PAD: ZMD.283. Immunogen: Fusion protein derived... ASIP/PAR-3 (atypical PKC isotype-specific interac...gen is not related to the protease-activated-recep...us (positive controls: Caco-2 MDCK A6 cell lysates...
Rabbit Anti-Human MTHFD1 Polyclonal Antibody, Unconjugated from Atlas Antibodies
BioPrime Array CGH Genomic Labeling Module from Invitrogen
GIBCO F-12 Nutrient Mixture (Ham) powder from Invitrogen
Biology Products:
(Date:11/24/2009)...ay named 12 new grant recipients for 2009. The awa...ork across a broad spectrum of lupus research. All...potential to drive scientific discovery to ultimat...f systemic lupus. , The 2009 grants go to both n...tion and include interdisciplinary and highly prom...
(Date:11/24/2009)...e class of ring-shaped protein motors has been unc...ational Laboratory (Berkeley Lab) using a state-of...dvanced Light Source (ALS). These protein motors p...on, and are vital to the survival of all biologica... human papillomavirus, which has been linked to ce...
(Date:11/24/2009)...r of debate. A high-profile study a few years ago ... carbon from trees and leaves, evidence for a very...osystems. , But new research from the University.... Algae provide a much richer diet for fish and ot...this week in the Proceedings of the National Acad...
Breaking Biology News(10 mins):Lupus Research Institute announces 2009 novel research grants 2Lupus Research Institute announces 2009 novel research grants 3Atomic-level snapshot catches protein motor in action 2Atomic-level snapshot catches protein motor in action 3Atomic-level snapshot catches protein motor in action 4Fish food fight: Fish don't eat trees after all, says new study 2Fish food fight: Fish don't eat trees after all, says new study 3Lexicon Announces Proposed Offering of 27 500 000 Shares of Common Stock 14390 1Lexicon Announces Proposed Offering of 27 500 000 Shares of Common Stock 14390 2Lexicon Announces Proposed Offering of 27 500 000 Shares of Common Stock 14390 3Subsidiary of Nova Biomedical Completes Acquisition of Assets of CCS Medicals Subsidiary Sanvita Inc 5309 1Subsidiary of Nova Biomedical Completes Acquisition of Assets of CCS Medicals Subsidiary Sanvita Inc 5309 2Cornerstone Pharmaceuticals Adds Acclaimed Cancer Research Pioneer Robert A Weinberg Ph D to Its Scientific Advisory Board 5305 1Cornerstone Pharmaceuticals Adds Acclaimed Cancer Research Pioneer Robert A Weinberg Ph D to Its Scientific Advisory Board 5305 2Cornerstone Pharmaceuticals Adds Acclaimed Cancer Research Pioneer Robert A Weinberg Ph D to Its Scientific Advisory Board 5305 3
...th a photograph that embodies the unexpected and ...rsity of Wisconsin-Madison graduate student Jenna ...ngineering Visualization Challenge, sponsored by t...e. , The image, "Polymazing," appears in the Sept...omewhat amazing, considering the subject of her ph...
...HILADELPHIA - Biophysicists at the University of P...d long-established data on cholesterol,s role in t...interaction between cholesterol and neurotransmitt...ehavior for the nicotinic acetylcholine receptor, ...lzheimer,s disease, Parkinson,s disease, schizophr...
...SHINGTON Members of the public can send their nam...st mission dedicated to understanding the effects ...bility on our climate. , The "Send Your Name Arou...rt in the science mission and place their names in...icipants can submit their information, is located ...
Other Biology News:UW science photo takes second in national contest 2Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue 2Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue 3Send your name around the Earth on NASA'S Glory mission 2
(Date:11/24/2009)..., SANMATEO,Calif.,Nov.24/PRNewswire-FirstCall/--...mpanyfocusedondevelopingandcommercializingnovelpai...nno,PresidentandChiefExecutiveOfficer,isscheduledt...rence,tobeheldDecember1-2,2009atTheNewYorkPalaceHo...iglieri,ChiefFinancialOfficer,willbeavailabletores...
(Date:11/24/2009)..., TSXVENTURE:HTL , TORONTO,Nov.24/PRNewswir...yCalottoCapitalInc.,aleadingproviderofadvancedlase...tilityclinicmarkets,todayreportedoperationalandfin...09. , ,Q32009Highlights,-Revenuewas$1.46millionc...was66.3percentcomparedwith66.1percentinQ3,2008,-Ne...
(Date:11/24/2009)... Program Connects Customers w...les Collected with DNA Genotek Products , ...009 -- DNA Genotek , a leading provider of produc... and preparation, today announced its new global p...ancements for DNA Genotek,s partner community and ...
(Date:11/23/2009)...antum computing promises ultra-fast communication,...sitive information. But trying to use quantum stat...cate business. Now two physicists have shown, math... in quantum communication, while keeping the infor...nt issue of Physical Review Letters and highligh...
Breaking Biology Technology:NeurogesX to Present at Piper Jaffray Health Care Conference 2NeurogesX to Present at Piper Jaffray Health Care Conference 3Hamilton Thorne announces third quarter results 2Hamilton Thorne announces third quarter results 3Hamilton Thorne announces third quarter results 4Hamilton Thorne announces third quarter results 5Hamilton Thorne announces third quarter results 6Hamilton Thorne announces third quarter results 7DNA Genotek Launches Global Partner Program 2DNA Genotek Launches Global Partner Program 3