Navigation Links
Fragment Library I: Large Volume with mixtures from ActiveSight

ProductsFragment Library I: Large Volume with mixtures from ActiveSight
Company ActiveSight
Item Fragment Library I: Large Volume with mixtures
Price 
Description 

A ready-to-use kit for a single fragment based screening project:

384 Individual compounds (5 uL each)

96 shape-diverse mixtures of 4 (5 uL each)

PDB and dictionary files for structure refinement

Individual compounds are dissolved in DMSO at ca. 200 mM, mixtures of 4 are at ca. 50 mM. Supplied in 5 96-well trays. Dilute library with protein crystallization solution to make soak solutions for a complete structure based fragment screening project. Includes CD-ROM containing a full description of each fragment including pdb and cif files for fitting and refinement with MIFit, CCP4 and other popular crystallographic software.

ActiveSight Fragment Library I consists of small fragments of "drug-like" molecules used to probe the functionality and shape of a protein binding site. The small size of the fragments allows "room to grow" through chemical elaboration to generate novel leads with high potency.

The majority of the compounds in library I consist of a single rigid core decorated with 1-3 short side groups. Average molecular weight of 142 Da; 95% of library members have weights in the range of 90-220 Da. Scaffolds include benzenes, pyridines, pyrimidines, indoles, indazoles, benzimidazoles, purines, pyrazoles, pteridines, cyclohexanes, napthalenes, quinolines, isoquinolines, quinazolines, piperidines, isoxazoles, oxazoles, thiazoles, and furans.

Sidegroups include -NH2, -OH, -CH3, -C(=O)(-NH2), -Br, -C-NH2, =O, -C(=O)(-OH), -F, -Cl, -SH, -CF3, -C(=O)(-NHOH),=NH,-C(=NH)(-NH2), -S(=O)(=O)(-NH2), -C(=O)(-CH3), -O-CH3, -C-OH

The fragments can be used singly or as mixtures to decrease the number of soaks and data sets needed. All of the fragments are commercially available for further chemical synthesis. Buying the library pre-made in plates will save considerable time and effort.

Info ActiveSightActiveSight
4045 Sorrento Valley Blvd.
San Diego, CA 92121 USA
Customer Service: 858-455-6870
Fax Number: 858-455-6932
Web Site: http://www.active-sight.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Fragment-based Screening Services from ActiveSight
2. DNA Polymerase I Large (Klenow) Fragment from New England Biolabs
3. Exo- Klenow Fragment (Cloned) from Ambion
4. DNA Polymerase I Large (Klenow) Fragment from Invitrogen
5. Klenow Fragment, Exonuclease Minus from Promega
6. ApoDIRECT DNA Fragmentation Assay Kit from MBL International
7. ApoBrdU DNA Fragmentation Assay Kit from MBL International
8. ApoBrdU Red DNA Fragmentation Kit from MBL International
9. Anti-Human IgG, Fd Fragment Monoclonal Antibody, Unconjugated from CHEMICON
10. DNA Fragment 2X Precipitation Solution from EPICENTRE Biotechnologies
11. Duck Anti-Cobra venom - Fab Fragment Polyclonal Antibody, Unconjugated from Abcam
Slide Chambers are convenient for performing pre-hybridization incubations and post-hybridization washes with tissue sections mounted on standard glass microscope slides. Each chamber holds up to 5 s...
Cord blood endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
... developed specifically for the stabilization of ... plates/strips. Coating Stabilizer maintains the ... or protein antigen portion of the ... filtered at 0.2 microns., ,Contents: ...
Biology Products:
(Date:1/4/2017)...  CES 2017 – Valencell , the leading ... the launch of two new versions of its ... sensor modules that incorporate the best of Valencell,s ... The two new designs include Benchmark BE2.0, a ... Benchmark BW2.0, a 2-LED version of its original ...
(Date:12/20/2016)... Dec, 20, 2016   Valencell , the ... and STMicroelectronics (NYSE: STM), a global semiconductor ... applications, announced today the launch of a new, ... wearables that includes ST,s compact SensorTile ... biometric sensor system. Together, SensorTile and Benchmark ...
(Date:12/15/2016)... and BADEN-BADEN, Germany , December ... leading global financial services provider, today announced an agreement with ... behavioural biometrics, to join forces. The partnership will enable clients ... strategies in compliance with local data protection regulation. ... In order to ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... Los Angeles, California (PRWEB) , ... January 11, ... ... collaborative approach to support fertility specialists with accurate and reliable preimplantation genetic screening ... and we have achieved excellent results,” says Ovation Fertility Genetics Scientific Director ...
(Date:1/11/2017)... ... January 11, 2017 , ... ... optics and photonics , are commending the U.S. Congress and President Obama for ... by the President of the American Innovation and Competitiveness Act (AICA). , The ...
(Date:1/11/2017)... ... January 11, 2017 , ... With ... healthcare systems more than $23.7 billion, healthcare systems are looking to provide ... the most common sepsis-causing pathogens are bacteria and the yeast pathogen Candida, which ...
(Date:1/11/2017)... ... January 11, 2017 , ... Microbial genomics leader uBiome, ... Its most recent microbiome impact grant award has been made to Dr. Eon ... long-term use of oral antibiotics, prescribed for skin conditions, on the gut microbiome. ...
Breaking Biology Technology: