Navigation Links
Fragment Library I: Large Volume with mixtures from ActiveSight

ProductsFragment Library I: Large Volume with mixtures from ActiveSight
Company ActiveSight
Item Fragment Library I: Large Volume with mixtures
Price 
Description 

A ready-to-use kit for a single fragment based screening project:

384 Individual compounds (5 uL each)

96 shape-diverse mixtures of 4 (5 uL each)

PDB and dictionary files for structure refinement

Individual compounds are dissolved in DMSO at ca. 200 mM, mixtures of 4 are at ca. 50 mM. Supplied in 5 96-well trays. Dilute library with protein crystallization solution to make soak solutions for a complete structure based fragment screening project. Includes CD-ROM containing a full description of each fragment including pdb and cif files for fitting and refinement with MIFit, CCP4 and other popular crystallographic software.

ActiveSight Fragment Library I consists of small fragments of "drug-like" molecules used to probe the functionality and shape of a protein binding site. The small size of the fragments allows "room to grow" through chemical elaboration to generate novel leads with high potency.

The majority of the compounds in library I consist of a single rigid core decorated with 1-3 short side groups. Average molecular weight of 142 Da; 95% of library members have weights in the range of 90-220 Da. Scaffolds include benzenes, pyridines, pyrimidines, indoles, indazoles, benzimidazoles, purines, pyrazoles, pteridines, cyclohexanes, napthalenes, quinolines, isoquinolines, quinazolines, piperidines, isoxazoles, oxazoles, thiazoles, and furans.

Sidegroups include -NH2, -OH, -CH3, -C(=O)(-NH2), -Br, -C-NH2, =O, -C(=O)(-OH), -F, -Cl, -SH, -CF3, -C(=O)(-NHOH),=NH,-C(=NH)(-NH2), -S(=O)(=O)(-NH2), -C(=O)(-CH3), -O-CH3, -C-OH

The fragments can be used singly or as mixtures to decrease the number of soaks and data sets needed. All of the fragments are commercially available for further chemical synthesis. Buying the library pre-made in plates will save considerable time and effort.

Info ActiveSightActiveSight
4045 Sorrento Valley Blvd.
San Diego, CA 92121 USA
Customer Service: 858-455-6870
Fax Number: 858-455-6932
Web Site: http://www.active-sight.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Fragment-based Screening Services from ActiveSight
2. DNA Polymerase I Large (Klenow) Fragment from New England Biolabs
3. Exo- Klenow Fragment (Cloned) from Ambion
4. DNA Polymerase I Large (Klenow) Fragment from Invitrogen
5. Klenow Fragment, Exonuclease Minus from Promega
6. ApoDIRECT DNA Fragmentation Assay Kit from MBL International
7. ApoBrdU DNA Fragmentation Assay Kit from MBL International
8. ApoBrdU Red DNA Fragmentation Kit from MBL International
9. Anti-Human IgG, Fd Fragment Monoclonal Antibody, Unconjugated from CHEMICON
10. DNA Fragment 2X Precipitation Solution from EPICENTRE Biotechnologies
11. Duck Anti-Cobra venom - Fab Fragment Polyclonal Antibody, Unconjugated from Abcam
B3GALT2 Immunogen: B3GALT2 (NP_003774, 324 a.a. ~ 423 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
XPC Immunogen: XPC (NP_004619, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Applications: Western blotting Stability: Room temperature, indefinitely ...
Goat polyclonal to Ephrin B2 ( Abpromise for all tested applications). entrezGeneID: 1948 SwissProtID: P52799...
Biology Products:
(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/18/2016)... 18, 2016 --> ... ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance ... in the border security market and the continuing migration crisis ... Europe has led visiongain to publish this ... --> defence & security companies in the ...
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... 27, 2016 , ... Weeks after hosting a carpal tunnel syndrome workshop with ... surgeon and founder of the Fitzmaurice Hand Institute, has announced the addition of MRI ... state-of-the-art technology and only 1 of about 3 currently available in the United States. ...
(Date:5/27/2016)... ... ... Doctors in Italy, Japan, the UK and the US have reached some surprising ... its link to malignant mesothelioma. Surviving Mesothelioma has just posted the details of their ... , The studies analyzed for the new report included more than 3,447 cancer patients. ...
(Date:5/27/2016)... At present, the Biotech sphere is in a ... volatility is what makes this industry interesting to consider. Here ... (NASDAQ: SNTA ), CTI BioPharma Corp. (NASDAQ: ... and Heat Biologics Inc. (NASDAQ: HTBX ). Sign ... these stocks at: http://www.activewallst.com/register/ ...
(Date:5/26/2016)... New Jersey and READING, ... Indegene ( http://www.indegene.com ), a leading ... to life science, pharmaceutical and healthcare organisations and ... of innovative scientific support throughout the product lifecycle, ... with the launch of IntraScience.      ...
Breaking Biology Technology: