Navigation Links
Fragment Library I: Large Volume with mixtures from ActiveSight

ProductsFragment Library I: Large Volume with mixtures from ActiveSight
Company ActiveSight
Item Fragment Library I: Large Volume with mixtures
Price 
Description 

A ready-to-use kit for a single fragment based screening project:

384 Individual compounds (5 uL each)

96 shape-diverse mixtures of 4 (5 uL each)

PDB and dictionary files for structure refinement

Individual compounds are dissolved in DMSO at ca. 200 mM, mixtures of 4 are at ca. 50 mM. Supplied in 5 96-well trays. Dilute library with protein crystallization solution to make soak solutions for a complete structure based fragment screening project. Includes CD-ROM containing a full description of each fragment including pdb and cif files for fitting and refinement with MIFit, CCP4 and other popular crystallographic software.

ActiveSight Fragment Library I consists of small fragments of "drug-like" molecules used to probe the functionality and shape of a protein binding site. The small size of the fragments allows "room to grow" through chemical elaboration to generate novel leads with high potency.

The majority of the compounds in library I consist of a single rigid core decorated with 1-3 short side groups. Average molecular weight of 142 Da; 95% of library members have weights in the range of 90-220 Da. Scaffolds include benzenes, pyridines, pyrimidines, indoles, indazoles, benzimidazoles, purines, pyrazoles, pteridines, cyclohexanes, napthalenes, quinolines, isoquinolines, quinazolines, piperidines, isoxazoles, oxazoles, thiazoles, and furans.

Sidegroups include -NH2, -OH, -CH3, -C(=O)(-NH2), -Br, -C-NH2, =O, -C(=O)(-OH), -F, -Cl, -SH, -CF3, -C(=O)(-NHOH),=NH,-C(=NH)(-NH2), -S(=O)(=O)(-NH2), -C(=O)(-CH3), -O-CH3, -C-OH

The fragments can be used singly or as mixtures to decrease the number of soaks and data sets needed. All of the fragments are commercially available for further chemical synthesis. Buying the library pre-made in plates will save considerable time and effort.

Info ActiveSightActiveSight
4045 Sorrento Valley Blvd.
San Diego, CA 92121 USA
Customer Service: 858-455-6870
Fax Number: 858-455-6932
Web Site: http://www.active-sight.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Fragment-based Screening Services from ActiveSight
2. DNA Polymerase I Large (Klenow) Fragment from New England Biolabs
3. Exo- Klenow Fragment (Cloned) from Ambion
4. DNA Polymerase I Large (Klenow) Fragment from Invitrogen
5. Klenow Fragment, Exonuclease Minus from Promega
6. ApoDIRECT DNA Fragmentation Assay Kit from MBL International
7. ApoBrdU DNA Fragmentation Assay Kit from MBL International
8. ApoBrdU Red DNA Fragmentation Kit from MBL International
9. Anti-Human IgG, Fd Fragment Monoclonal Antibody, Unconjugated from CHEMICON
10. DNA Fragment 2X Precipitation Solution from EPICENTRE Biotechnologies
11. Duck Anti-Cobra venom - Fab Fragment Polyclonal Antibody, Unconjugated from Abcam
... Benzonase Nuclease is a genetically engineered endonuclease. ... DNA and RNA while having no proteolytic ... range of conditions and possesses an exceptionally ... nucleic acids from recombinant proteins, its use ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Rice microRNA Microarray contains ...
... manufactured by Stoelting, selects single cells, or ... no time at all, a single cell ... keypad...the cell is collected into the pipette, ... of a microtiter plate. Quixells unique aspiration ...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known maize microRNAs ...
Biology Products:
(Date:11/13/2018)... ... November 12, 2018 , ... Board-certified periodontist Dr. Jin ... individuals with multiple missing teeth in Santa Ana, CA and surrounding areas, who want ... Using decades of experience, Dr. Kim regularly helps patients get the advantages that come ...
(Date:11/13/2018)... ... November 13, 2018 , ... Kenall has enhanced the popular MedMaster ... options. These redesigned linear overbed luminaires are equipped with symmetric ambient and asymmetric exam ... and dust. , Intended to be specified in pairs, the MAEC is 8” x ...
(Date:11/9/2018)... ... November 08, 2018 , ... Boekel Scientific ... blocks, also known as dry bath incubators are used in laboratories worldwide for ... , For the new heating blocks, Boekel Scientific used the same interface design ...
Breaking Biology News(10 mins):
(Date:11/3/2018)... (PRWEB) , ... November 01, 2018 , ... Triangle Insights ... Inc. Magazine as one of the fastest-growing private companies in the United States, appearing ... 5000 list ranks private companies based on percentage revenue growth over the previous three ...
(Date:10/31/2018)... Calif. (PRWEB) , ... October 30, 2018 , ... ... experimental manipulation continue to be a very important aspect of experimental biology. Reproducibility ... reliability of experimental data. Despite of choosing the appropriate assay type, there are ...
(Date:10/24/2018)... ... 2018 , ... Erchonia, the leading low-level laser technology manufacturer ... episode of CBS’s hit show “The Doctors” which aired on Friday, ... discusses and demonstrates the Lunula Laser’s unique capacity to zap away toe nail ...
(Date:10/18/2018)... ... 18, 2018 , ... R3 Stem Cell is now offering a 20% Early ... The discount is good through November 7th, 2018, with the course taking place December ... workshop includes an amazing useful array of hands on therapies with real patients. The ...
Breaking Biology Technology: