|Products||Custom 2'-OMe RNA Aptamer Microarray from LC Sciences|
|Item||Custom 2'-OMe RNA Aptamer Microarray|
|Description|| Microarrays designed for RNA aptamer screening and binding optimization and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. Thousands of customer specified RNA sequences can be synthesized on-chip and LC Sciences can provide assistance with custom sequence design. These microarrays are available as part of our comprehensive DNA/RNA Aptamer Microarray Service.|
These are not spotted arrays. The Paraflo microfluidic technology enables on-chip synthesis ensuring high probe quality, tight process control, and complete content flexibility. In addition, the microfluidic technology produces a uniform distribution of the sample solutions on the array and enhances binding reactions and stringency wash processes.
Multiple QC steps are implemented at various stages of the array manufacturing process. Based on the reading from 16 sets of control probes spatially distributed across the array, signal intensities, spot uniformity, cross-array spot-to-spot uniformity, and perfect-match vs. mismatch specificities are thoroughly evaluated.
LC Sciences is a genomics and proteomics company offering innovative, customizable, and comprehensive microarray services for nucleic acid/protein profiling and functional analysis, biomarker-discovery, novel drug screening, and the custom development of diagnostic devices. We provide unique one-stop products and services for assays of DNA, RNA, protein, enzymes, antibodies, or small molecules, as well as proven microfluidic technology and novel microarray chemistry for design of your miniaturized assay devices for diagnostics and biosensing applications.
Our microarray services include the use of custom synthesized microarrays based on the Paraflo on-chip synthesis technology (1,2) which enables the total customization of content on each individual microarray. Our customers have the flexibility to use our standard probe content or their own custom designed probe content and to use probes of their chosen lengths and number of replicates. The Paraflo technology also provides the flexibility of synthesizing microarrays containing probes with modifications such as, 5-amino linker, phosphate, biotin, and various methylation or other types of modifications. Incorporation of modifications greatly increases the number of applications for these microarrays.
LC Sciences offers additional Paraflo technology derived products that serve customers needs for construction of biomolecular libraries containing up to millions of different biomolecules of defined sequences. These products significantly reduce the cost and increase the speed of highly multiplexing genome-scale experiments such as exploration of small RNAs and designer gene/DNA library synthesis.
(1) Tian, J., Gong, H., Sheng, N., Zhou, X., Gulari, E., Gao, X., and Church, G. (2004) Accurate multiplex gene synthesis from programmable DNA chips. Nature 432, 1050-1054.
(2) Zhou, X., Cai, S., Hong, A., Yu, P., Sheng, N., Srivannavit, O., Yong, Q., Muranjan, S., Rouillard, J. M., Xia, Y., Zhang, X., Xiang, Q., Ganesh, R., Zhu, Q., Makejko, A., Gulari, E., and Gao, X. (2004) Microfluidic picoarray synthesis of oligodeoxynucleotides and simultaneously assembling of multiple DNA sequences. Nucleic Acids Res. 32, 5409-5417.
|Info|| LC Sciences|
2575 W. Bellfort
Houston, TX 77054
Fax Number: (713) 664-8181
Web Site: http://www.lcsciences.com