Antisense oligonucleotides from Thermo Scientific

Products	Antisense oligonucleotides from Thermo Scientific
Company	Thermo Scientific
Item	Antisense oligonucleotides
Price
Description	Phosphothioate (PTO) oligonucleotides: PTOs are internucleotide modifications, where one oxygen atom in the phosphate backbone is replaced by a sulphur atom. This modification stabilises the oligonucleotide against nuclease degradation. PTOs are available as Full-PTOs All internucleotide linkages are phosphothioates Oligonucleotides with thio-caps Several internucleotide linkages at the 3 and/or 5 end are synthesised as phosphothioates (PTOs) to prevent enzymatic degradation. Inverted end 3-3 linkage to prevent enzymatic degradation and chain elongation.Lit: J.F.R. Ortigao, H. Rosch, H. Selter, A. Frohlich, A. Lorenz, M. Montenarh, and H. Seliger, Antisense Res. & Dev., 1992, 2, 129-146 2-O-Methyl-RNA Oligos from 10 to 105 bases, purified by HPLC and MS-checked.The methyl residue at the 2-OH of the ribose stabilises the oligo against nuclease degradation.
Info	Thermo Scientific 450 Fortune Blvd. Milford, MA 01757 Customer Service: North America: 1-877-THERMO-U Fax Number: 508-520-2229 Web Site: http://www.thermo.com

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TAG: Antisense oligonucleotides from Thermo Scientific

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