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Antisense oligonucleotides from Thermo Scientific

ProductsAntisense oligonucleotides from Thermo Scientific
Company Thermo Scientific
Item Antisense oligonucleotides
Description Phosphothioate (PTO) oligonucleotides:
PTOs are internucleotide modifications, where one oxygen atom in the phosphate backbone is replaced by a sulphur atom. This modification stabilises the oligonucleotide against nuclease degradation. PTOs are available as
All internucleotide linkages are phosphothioates
Oligonucleotides with thio-caps
Several internucleotide linkages at the 3 and/or 5 end are synthesised as phosphothioates (PTOs) to prevent enzymatic degradation.

Inverted end
3-3 linkage to prevent enzymatic degradation and chain elongation.Lit: J.F.R. Ortigao, H. Rosch, H. Selter, A. Frohlich, A. Lorenz, M. Montenarh, and H. Seliger, Antisense Res. & Dev., 1992, 2, 129-146

Oligos from 10 to 105 bases, purified by HPLC and MS-checked.The methyl residue at the 2-OH of the ribose stabilises the oligo against nuclease degradation.

Info Thermo ScientificThermo Scientific
450 Fortune Blvd.
Milford, MA 01757
Customer Service: North America: 1-877-THERMO-U
Fax Number: 508-520-2229
Web Site:
NOTE: Price information is approximate list price and actual prices may vary.

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