Navigation Links
Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen

ProductsAnti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen
Company Invitrogen
Item Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177
Price 
Description The JNK (c-Jun NH2-terminal kinase) signal transduction cascade is one of three identified MAP kinase pathways in mammals. JNK pathway activation occurs in response to environmental stress, is associated with the nuclear accumulation of JNK itself, and is implicated in the immune response, cellular proliferation, oncogenic transformation, morphogenesis, and apoptosis.JIP1 (JNK-interacting protein-1, also known as Islet Brain-1 and mitogen-activated protein kinase 8-interacting protein-1,) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal SRC homology 3 (SH3) domain. Its SH3 domain is related to the SH3 domains of the tyrosine kinase c-Fyn and the p85 subunit of phosphoinositide-3 kinase (PI3K). Overexpression of JIP1 causes cytoplasmic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathway. This observation led to the original hypothesis that JIP1 acts as a cytoplasmic anchor for JNK.JIP1 has been shown to bind selectively to JNK but not to the ERK or p38 MAP kinases; it has also demonstrated selectivity in its binding to specific proteins of the JNK pathway. In addition to JNK, JIP1 binds to the JNK activator MKK7 (MAP kinase kinase 7) and the MKK7 activators MLK3 (mixed-lineage protein kinase 3) and DLK (dual leucine zipper-bearing kinase), all at separate binding sites. JIP1s assembly of multiple components of the JNK pathway into a functional signaling module provides precise regulation of the JNK cascade and defines JIP1 as a JNK-scaffolding protein. Multiple transcription variants of JIP1 have been cloned: JIP1 has been identified in brain and kidney tissues while JIP2a, JIP2b, and JIP3 are specifically expressed in the brain, particularly in the adult cerebral cortex and hippocampus. All JIP1 isoforms inhibit JNK signaling when overexpressed. A recent study has discovered a direct interaction between JIP1 and amyloid-b-precursor protein (APP), the precursor to the b-amyloid peptide that comprises the amyloid plaques characteristic of Alzheimers disease, in the adult mouse brain. Taken together with previous reports of active JNK in the brains of Alzheimers disease patients, this evidence suggests that the JNK signaling pathway, and thus the scaffolding function of JIP1, may be fundamental to the progression of Alzheimers disease.
Info InvitrogenInvitrogen
Invitrogen Corporation
1600 Faraday Ave.
Carlsbad, CA 92008

Call Invitrogen to buy products (US and Canada only; other locations use numbers below)
USA Canada 1-866-521-4270
Customer Service: 800-955-6288
Tech Support: 800-955-6288 ext. 2
Fax Number: 760-603-7229
Web Site: http://www.invitrogen.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen
2. Rabbit Anti-JIP 1 Polyclonal Antibody, Unconjugated from BioVision
3. Goat Anti-TGase3 (S-20) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
4. Rabbit Anti-Aph-1aL, S Loop (92-115) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc
5. Goat Anti-SCCRO (S-17) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
6. Rabbit Anti-Human Vitamin K-dependent Protein S (PROS1) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
7. Goat Anti-ZBP-89 (S-15) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
8. Goat Anti-XPLAC (S-17) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
9. Rabbit Anti-Human Sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7 (SIRT7) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
10. Goat Anti-Human RORgamma (S-14) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
11. Rabbit Anti-Esa1 Polyclonal Antibody, Unconjugated from Abcam
... GeneBLAzer cell-based assays utilize the membrane-permeant ... the negatively charged fluorescent beta-lactamase substrates, ... readily enter the cell, where cleavage ... them into their negatively charged forms, ...
Inquire...
Homogenizing Solution, 18ml Proteinase K - [50ug/l] 75 l...
Rb anti-Occludin (C-term GST)...
Biology Products:
(Date:6/4/2019)... ... 04, 2019 , ... Harper was three years old when her owners took ... which caused painful osteoarthritis in the joints. She was referred to a veterinary ... The surgical specialist, Dr. Christopher Eich of Southern California Veterinary Specialty Hospital , ...
(Date:6/3/2019)... ... June 03, 2019 , ... Stay on top of current hot ... food industries. Access to all webinars is free, so be sure to register today ... , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , ...
(Date:5/31/2019)... VIEJO, Calif. (PRWEB) , ... May 30, 2019 ... ... leading clinical genetics testing company, and Mayo Clinic, have documented significant differences in ... cancer among racial and ethnic populations compared to non-Hispanic White women. Results will ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... TORONTO (PRWEB) , ... May 29, 2019 , ... For ... but the toughest forms of cancer demand breakthrough therapies. Advances in immuno-oncology have led ... a patient’s own T cells with engineered T cell receptors known as “CARs”. The ...
(Date:5/22/2019)... ... ... Artemis (formerly Agrilyst), the leading enterprise Cultivation Management Platform (CMP), today ... Astanor Ventures and Talis Capital with participation from existing investors New ... company has raised $11.75m to date and will use the new funding to rapidly ...
(Date:5/14/2019)... ... May 14, 2019 , ... Gateway Genomics , a ... its space from 2,500 to 5,000 square feet. , “This past year has ... ,” says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed ...
(Date:5/2/2019)... BELTSVILLE, Md. (PRWEB) , ... ... ... certification to the International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA ... consistently meet customer requirements. In addition, REPROCELL USA Inc. aims to enhance ...
Breaking Biology Technology: