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Anti-Integrin alphaVbeta3 (CD51 / CD61) Monoclonal Antibody, Biotin Conjugated, Clone LM609 from CHEMICON

ProductsAnti-Integrin alphaVbeta3 (CD51 / CD61) Monoclonal Antibody, Biotin Conjugated, Clone LM609 from CHEMICON
Item Anti-Integrin alphaVbeta3 (CD51 / CD61) Monoclonal Antibody, Biotin Conjugated, Clone LM609
Price $290.00
Description The involvement of integrins in vascular proliferation, adhesion, and wound repair have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an a and b subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual a and b subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor.3 Due to its involvement in angiogenesis, the integrin aVb3 receptor is one of the most intensely studied of the integrin receptors.Monoclonal antibody MAB1976B is reactive with the vitronectin receptor aVb3 complex, an RGD-directed adhesion receptor.
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