|Products||Anti-Cullin-3 (CUL-3) Ab-1 Polyclonal Antibody, Unconjugated from Lab Vision|
|Item||Anti-Cullin-3 (CUL-3) Ab-1 Polyclonal Antibody, Unconjugated|
|Description|| CUL-3 is a member of the family of human cullin genes (CUL-1, -2, -3, -4a, -4b, and -5), homologous to the S. cerevisiae cdc53 gene. Cullin-3 is proposed to be a part of E3 protein-ubiqutinnn ligase. It forms a tight complex with cyclin E and targets it for ubiquitination, which leads to its degradation by protesomes. Cyclin E is an activator of cdk2, which leads the cell to S phase. Cul-3-/- mice show increased accumulation of Cyclin E protein and disruption of normal cell cycle regulation in vivo. Thus Cullin-3 is important in the regulation of S phase of cell cycle.|
Species Reactivity: Human and Mouse. Others-not tested.
|Info|| Lab Vision|
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