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8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha from Cayman Chemical

Products8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha from Cayman Chemical
Company Cayman Chemical
Item 8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha
Price $38.00
Description 8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits. Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.
Info Cayman ChemicalCayman Chemical
Cayman Chemical Company
1180 East Ellsworth Road
Ann Arbor, Michigan 48108
Customer Service: (800) 364-9897
Fax Number: (734) 971-3640
Web Site:
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