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26S Proteasome Fraction Extract from GeneTex

Products26S Proteasome Fraction Extract from GeneTex
Company GeneTex
Item 26S Proteasome Fraction Extract
Price $350.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80880 contains the full Hela cell compliment of ubiquitin activating enzyme (E1), ubiquitin conjugating enzymes (E2s), 20S and 26S proteasomes, isopeptidase, proteasome PA28/11S REG complex, and ubiquitin ligase enzymes (E3s). GTX80880 is ideal for demonstrating ubiquitin proteasome degradation/conjugation of radiolabeled or immunodetectable substrates.

  • Type: Proteins and peptides
  • Form: 7.5 mg/ml in 25 mM HEPES, pH 7.6.
Info GeneTexGeneTex
14785 Omicron Dr. Suite101
San Antonio, TX 78245
Customer Service: (877) 436-3839
Fax Number: (210) 677-8843
Web Site: http://www.genetex.com
NOTE: Price information is approximate list price and actual prices may vary.

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