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15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester from Cayman Chemical

Products15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester from Cayman Chemical
Company Cayman Chemical
Item 15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester
Price $1,855.00
Description 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 µg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
Info Cayman ChemicalCayman Chemical
Cayman Chemical Company
1180 East Ellsworth Road
Ann Arbor, Michigan 48108
Customer Service: (800) 364-9897
Fax Number: (734) 971-3640
Web Site:
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