Navigation Links
p53, tumor suppression and aging

In the January 1 issue of Genes & Development, Dr. Mary Ellen Perry and colleagues validate the p53 inhibitor, Mdm2, as a promising target for cancer therapies.

The p53 tumor suppressor plays a critical role in cancer formation, and many anticancer strategies aim to activate p53 in order to curb tumor formation. Mdm2 is a key inhibitor of p53 and therefore an attractive target to modulate p53 activity in cells. However, conflicting evidence exists regarding whether or not p53-mediated tumor suppression comes at the cost of accelerated aging.

To analyze the effects of reduced Mdm2 levels on tumorigenesis ?as well as the potential for unwanted side effects ?Dr. Perry's team used mdm2-hypomorphic mice (that express less Mdm2 protein than normal mice) which have elevated levels of wild-type p53 activity. The researchers found that even a modest decrease (about 20%) in Mdm2 effectively prevents tumor formation and does not lead to premature aging.

Dr. Perry emphasizes that "many people develop cancer at a young age due to increased expression of Mdm2. The possibility that inhibitors of Mdm2 could delay cancer in such people without causing detrimental side effects is bolstered by our demonstration that mice expressing 30-80% the normal level of Mdm2 develop fewer tumors than wild type mice, yet age normally."


'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Mouse brain tumors mimic those in human genetic disorder
2. Researchers add new tool to tumor-treatment arsenal
3. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
4. Pulsating ultrasound enhances gene therapy for tumors
5. Scientists identify molecule that regulates well-known tumor suppressor
6. New tumor-suppressor gene discovered
7. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
8. Natural tumor suppressor in body discovered by UCSD medical researchers
9. Unexpected lock and key mechanism found for the assembly of tumor blood vessels
10. Nanoparticles carry cancer-killing drugs into tumor cells
11. New lead reported in tumor angiogenesis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Vortex Biosciences , provider of circulating ... prostate circulating tumor cells using Vortex microfluidic technology ” in Nature Precision Oncology on ... Dr. Dino Di Carlo and Dr. Matthew Rettig at the University of California, Los ...
(Date:5/23/2017)... Philadelphia, PA. (PRWEB) , ... May 23, 2017 ... ... Clinical Works as Vice President of Clinical Operations. She brings years ... Pharmaceuticals, and Yaupon Therapeutics. From her professional foundation as a licensed occupational therapist, ...
(Date:5/23/2017)... ... May 23, 2017 , ... Cambridge Semantics , the leading provider of ... Bio-IT World Conference and Expo in Boston May 23-25 with a featured speaker ... Anzo Smart Data Lake is also a finalist for the Best of Show award. ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... Stratevi, a ... expanded to the East Coast. It has opened an office in downtown Boston at ... are finding it increasingly more important to generate evidence on the value they provide, ...
Breaking Biology Technology: