Navigation Links
miRNA-mediated silencing of mRNAs

Dr. Elisa Izaurrralde and colleagues (EMBL; Max-Planck-Institute for Developmental Biology-Tuebingen) provide new mechanistic insight into gene silencing by miRNAs

Their paper will be featured on the cover of the July 15th issue of G&D, and also will be made available online in advance on 7/3.

MicroRNAs (miRNAs) are a novel class of small regulatory RNAs that silence the expression of complementary mRNA targets.

Dr. Izaurralde and colleagues demonstrate that the P-body protein, GW182, interacts with the miRNA effector Argonaute proteins as well as mRNA degradation enzymes, to promote target mRNA decay. The authors establish that GW182 functions downstream of the Argonaute-1 protein in the miRNA pathway, targeting transcripts for decay via a deadenylation and decapping reaction.

The question of whether miRNAs silence gene expression without affecting mRNA levels has been controversial, and conflicting results have been reported in the literature. Dr. Izaurralde explains that, "Our findings reveal that miRNAs silencing gene expression by at least two independent mechanisms: by repression of translation and/or by induction of mRNA degradation. This provides an explanation for changes in mRNA levels observed at least for a subset of miRNA targets."


'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
2. Gene silencing technique offers new strategy for treating, curing disease
3. Molecular steps involved in the creation of gene-silencing microRNAs identified
4. Twin molecular scissors link creation of microRNAs with gene-silencing
5. New mechanism for essential genome-wide gene silencing identified
6. Pathway toward gene silencing described in plants
7. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... CA (PRWEB) , ... June 20, 2017 , ... ... technology for discovery of antibody therapeutics from millions-diverse immune repertoires, announces launch of ... in San Diego, California. Dave Johnson, PhD, CEO of GigaGen, will present on ...
(Date:6/16/2017)... ... June 16, 2017 , ... ... commercialization, has just announced two more sessions of its “From the Helm” Webinar ... on the world of online templates for design control exercises. Led by David ...
(Date:6/15/2017)... ... June 15, 2017 , ... The newest exhibition at the ... creative experimentation and interdisciplinary collaboration. Feature Creep, a solo exhibition by Maximillian Lawrence, ... will be held at EKG, located at 3600 Market Street in Philadelphia, on ...
(Date:6/14/2017)... Bangkok, Thailand (PRWEB) , ... June 14, 2017 ... ... Thailand Center of Excellence for Life Sciences (TCELS) announces that they’re co-hosting a ... 19-22, 2017. , BIO, the largest biotech industry gathering in the world, ...
Breaking Biology Technology: