Navigation Links
miRNA-mediated silencing of mRNAs

Dr. Elisa Izaurrralde and colleagues (EMBL; Max-Planck-Institute for Developmental Biology-Tuebingen) provide new mechanistic insight into gene silencing by miRNAs

Their paper will be featured on the cover of the July 15th issue of G&D, and also will be made available online in advance on 7/3.

MicroRNAs (miRNAs) are a novel class of small regulatory RNAs that silence the expression of complementary mRNA targets.

Dr. Izaurralde and colleagues demonstrate that the P-body protein, GW182, interacts with the miRNA effector Argonaute proteins as well as mRNA degradation enzymes, to promote target mRNA decay. The authors establish that GW182 functions downstream of the Argonaute-1 protein in the miRNA pathway, targeting transcripts for decay via a deadenylation and decapping reaction.

The question of whether miRNAs silence gene expression without affecting mRNA levels has been controversial, and conflicting results have been reported in the literature. Dr. Izaurralde explains that, "Our findings reveal that miRNAs silencing gene expression by at least two independent mechanisms: by repression of translation and/or by induction of mRNA degradation. This provides an explanation for changes in mRNA levels observed at least for a subset of miRNA targets."


'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
2. Gene silencing technique offers new strategy for treating, curing disease
3. Molecular steps involved in the creation of gene-silencing microRNAs identified
4. Twin molecular scissors link creation of microRNAs with gene-silencing
5. New mechanism for essential genome-wide gene silencing identified
6. Pathway toward gene silencing described in plants
7. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
Breaking Biology Technology: