Navigation Links
miRNA-mediated silencing of mRNAs

Dr. Elisa Izaurrralde and colleagues (EMBL; Max-Planck-Institute for Developmental Biology-Tuebingen) provide new mechanistic insight into gene silencing by miRNAs

Their paper will be featured on the cover of the July 15th issue of G&D, and also will be made available online in advance on 7/3.

MicroRNAs (miRNAs) are a novel class of small regulatory RNAs that silence the expression of complementary mRNA targets.

Dr. Izaurralde and colleagues demonstrate that the P-body protein, GW182, interacts with the miRNA effector Argonaute proteins as well as mRNA degradation enzymes, to promote target mRNA decay. The authors establish that GW182 functions downstream of the Argonaute-1 protein in the miRNA pathway, targeting transcripts for decay via a deadenylation and decapping reaction.

The question of whether miRNAs silence gene expression without affecting mRNA levels has been controversial, and conflicting results have been reported in the literature. Dr. Izaurralde explains that, "Our findings reveal that miRNAs silencing gene expression by at least two independent mechanisms: by repression of translation and/or by induction of mRNA degradation. This provides an explanation for changes in mRNA levels observed at least for a subset of miRNA targets."


'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
2. Gene silencing technique offers new strategy for treating, curing disease
3. Molecular steps involved in the creation of gene-silencing microRNAs identified
4. Twin molecular scissors link creation of microRNAs with gene-silencing
5. New mechanism for essential genome-wide gene silencing identified
6. Pathway toward gene silencing described in plants
7. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/16/2016)... 2016 The global wearable medical device market, in terms ... from USD 5.31 billion in 2016, at a CAGR of 18.0% ... ... advancements in medical devices, launch of a growing number of smartphone-based ... among healthcare providers, and increasing focus on physical fitness. ...
(Date:12/15/2016)... , Dec. 15, 2016   WaferGen Bio-systems, ... held genomics technology company, announced today that on December ... Qualifications Department of The Nasdaq Stock Market LLC which ... bid price of WaferGen,s common stock had been at ... WaferGen has regained compliance with Listing Rule 5550(a)(2) of ...
(Date:12/15/2016)... , Dec. 15, 2016 Advancements ... experience, health wellness and wellbeing (HWW), and ... in three new passenger vehicles begin to ... gesture recognition, heart beat monitoring, brain wave ... facial monitoring, and pulse detection. These will ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... , Jan. 20, 2017 Bioptix, ... the "Company"), announced that on January 14, 2017 the ... under which the Company will terminate certain employees associated ... Diagnostics, Inc.  The Company commenced terminations on January 16, ... 30 days.  The Company may pay severance benefits in ...
(Date:1/20/2017)... ... , ... The two newest companies to join the University City Science Center’s ... from The Wistar Institute, and Sanguis, launched by a trio of students from the ... Vironika is developing a treatment for a chronic viral infection and its associated diseases, ...
(Date:1/20/2017)... 2017 http://www.Financialbuzz.com - ... leading causes of death worldwide. There were 8.2 million ... cancer related deaths increased gradually over time, the death ... of various cancers continues to drive demand of biological ... Global Market Insights, Inc. cancer biological therapy market size was ...
(Date:1/19/2017)... PUNE, India , Jan. 19, 2017  Market Research Future ... The Global Market for Liquid Biopsy is growing rapidly and expected ... period. Market Highlights ... The Global Liquid Biopsy Market has been assessed as ... high growth figures and boom in the coming future. There has ...
Breaking Biology Technology: