Navigation Links
Zebrafish may hold key to understanding human nerve cell development

Glia appear essential for 'hair cells' responsible for hearing and balance. Traditionally viewed as supporting actors, cells known as glia may be essential for the normal development of nerve cells responsible for hearing and balance, according to new University of Utah research. The study is reported in the January 6, 2005 issue of Neuron and is co-authored by scientists at the University of Washington. "Using zebrafish as a model, we've demonstrated that glial cells play a previously unidentified role in regulating the development of sensory hair cell precursors -- the specialized neurons found in the inner ear of humans that make hearing possible. This research increases our understanding of how nerve cells develop and whether it may be possible to regenerate these types of cells in humans one day," said Tatjana Piotrowski, Ph.D., assistant professor of neurobiology and anatomy at the University of Utah School of Medicine.

Scientists long have known that glial cells, or simply glia, are essential for healthy nerve cells. However, in the last 10 years scientists have learned that glia aren't just "glue" holding nerve cells together. Glia communicate with each other and even influence synapse formation between neurons. Piotrowski's research in zebrafish focuses on the development of sensory neurons known as hair cells. Like humans, zebrafish use hair cells to detect sound and motion. However, in humans hair cells are buried deep inside the inner ear making them difficult to access. Hair cells in zebrafish are located on the surface of their body and help the fish swim in groups and avoid predators. "Zebrafish are a wonderful model for studying hair cell development for a number of reasons. The hair cells are exposed and can be easily seen under the microscope in the live fish. We can also visually identify the consequences of gene defects in the 200 to 300 embryos each female fish produces," she said. By studying these mutant embryos, Piotrowski and her coll eagues discovered that during development the zebrafish is "seeded" with future hair cells through a process known as placode migration. These precursor cells, called interneuromast cells, eventually go on to make hair cells, but only when they are sufficiently far enough away from the glial-ensheathed nerve. "Once these cells are far enough away from the glia they begin to differentiate into hair cells. We know something in the glia is regulating development and acting as an inhibitory cue. It's possible that this signal could also play a role in the development of stem cells throughout the nervous system. Much more research is needed to identify this signal but we're optimistic our work has set the stage for future discoveries," said Piotrowski. The University of Utah has one of the largest zebrafish facilities in the country with more than 6,000 zebrafish tanks. In addition to Piotrowski, six other University faculty members use the fish to study various clinical disorders including leukemia, colon cancer, congenital heart defects, muscular dystrophy and other birth defects.
'"/>

Source:Eurekalert


Related biology news :

1. Zebrafish may hold key to improved cancer research
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
4. Researchers make gains in understanding antibiotic resistance
5. Brain-mapping technique aids understanding of sleep, wakefulness
6. New understanding of DNA repair may pave way to cancer treatments
7. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
8. Virologists make major step towards understanding the process of HIV infection
9. New understanding of cell movement may yield ways to brake cancers spread
10. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
11. New understanding of jet lag

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:5/24/2016)... 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology to ... display is the latest premium product recently added to the range of products distributed ... ... ... Imaging- LCD Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... Parallel 6 ... trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT module which ... with the physician and clinical trial team. , Using the CONSULT module, patients and ...
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
(Date:6/24/2016)... NC (PRWEB) , ... June 24, 2016 , ... Researchers ... the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are ... to read it now. , Diagnostic biomarkers are signposts in the blood, lung ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology: