Navigation Links
Zebrafish may hold key to improved cancer research

A new study has confirmed that research done with zebrafish may be able to play a critical role in learning about the genetic basis of cancer and the mutations that can lead to it - and identified one gene in particular, B-myb, whose function is essential to preventing tumors.

The findings were published in a professional journal, Proceedings of the National Academy of Sciences, by researchers from Oregon State University and two Boston hospitals, the Brigham and Women's Hospital and Children's Hospital.

The research also indicates that zebrafish may be a key to faster, less expensive studies on cancer and carcinogens, as well as a tool to lower the cost for drug development, OSU experts said.

The first comprehensive cancer research studies using this small, striped tropical fish were begun at OSU over 10 years ago, and the species has become an important tool in medical research programs around the world.

"It's increasingly clear that in zebrafish we have an animal model that is inexpensive, easy to work with and extremely useful for study of human cancers," said Jan Spitsbergen, a fish pathologist in OSU's Center for Fish Disease Research. "We've now proven that most of the carcinogens that affect humans are also active in zebrafish and can lead to the same types of cancer, whether it's in the brain, blood, reproductive organs or elsewhere."

The newest finding about the gene B-myb is especially compelling, said Spitsbergen. The B-myb gene has been conserved through hundreds of millions of years of divergent evolution in species ranging from worms to fruit flies, fish and humans.

When it functions normally, B-myb appropriately regulates cell proliferation. When it becomes mutated, either through genetic predisposition or environmental influences, the formation of tumors can dramatically increase, scientists say. The gene appears to be particularly relevant to human leukemias.

OSU's fish disease research program
'"/>

Source:Oregon State University


Page: 1 2 3

Related biology news :

1. Zebrafish may hold key to understanding human nerve cell development
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Scientists discuss improved biopesticides for locust control in West Africa
4. Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
5. Novel method reveals how menthol discovery could point towards new or improved pain therapies
6. UF scientists test improved gene therapy method for hereditary heart conditions
7. Report calls for improved monoclonal antibodies against solid tumors
8. End-of-life care can be improved
9. Viral DNA sequence a possible trigger for breast cancer
10. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
11. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Zebrafish may hold key improved cancer research

(Date:8/27/2014)... puts into doubt the long-standing belief that a deficiency ... plays a central role in depression. In the ... mice lacking the ability to make serotonin in their ... wisdom) did not show depression-like symptoms. , Donald ... Medical Center and Wayne State University School of Medicine ...
(Date:8/27/2014)... against trans-fats have largely succeeded in sidelining the ... sugar for its potential contributions to Americans, health ... over the best way to assuage the nation,s ... Chemical & Engineering News (C&EN), the ... , In the article, Stephen Ritter, a senior ...
(Date:8/27/2014)... shown that piglets can be weaned later with no ... of the study at the University,s Roseworthy campus, published ... an important finding for pig producers. It allows improvements ... , "Sows don,t usually start their oestrous cycles again ... have been weaned," says Ms Alice Weaver, PhD candidate ...
Breaking Biology News(10 mins):New study throws into question long-held belief about depression 2Piglet weaning age no bar to litter frequency 2
... This press release is available in French , ... STOCKHOLM (24 AUGUST 2012) As food prices ... the "super drought" in the US, a new study finds that ... and climate risks in sub-Saharan Africa and South Asia. The International ...
... 2012) A nanoparticle developed at Rice University and ... may bring great benefits to the emergency treatment of ... polyethylene glycol-hydrophilic carbon clusters (PEG-HCC), already being tested to ... studies, injections of PEG-HCC during initial treatment after an ...
... a phenomenon never seen before in plants while studying molecular ... In research published online in Proceedings of the National ... team found that one member of a family of proteins ... involved in forming wood, which includes a substance called lignin ...
Cached Biology News:Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 2Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 3Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 4Nanoparticles reboot blood flow in brain 2Nanoparticles reboot blood flow in brain 3
(Date:8/27/2014)... MONMOUTH JUNCTION, N.J. , Aug. 27, 2014 /PRNewswire/ ... developing innovative drug delivery technologies, today announced that it ... New Jersey Business & Industry Association,s 2014 Awards ... Finalists were selected by an independent panel of judges ... member company volunteers. Award winners will be honored at ...
(Date:8/27/2014)... According to the 2013 Raw Material and ... and feel of markets for raw materials and ingredient ... push for more branded, science-backed products.” , Natural products ... growth in the last decade as consumers increasingly demand ... to fit a more ‘wellness’ lifestyle approach. Due ...
(Date:8/26/2014)... what they believe is the thinnest-possible semiconductor, a ... only three atoms thick. , The University of ... single-layer semiconductor materials can be connected in an ... result could be the basis for next-generation flexible ... and solar technologies. , "Heterojunctions are fundamental elements ...
(Date:8/26/2014)... 2014 The 20 ambassadors representing the ... community issued the following statement on Facebook today regarding ... driving new funding specifically for ALS research: , “Who ... some ice would raise all this awareness and funding ... and on behalf of the entire ALS community, would ...
Breaking Biology Technology:Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... , SAN FRANCISCO , ... a leader in Integrated Voice Response (IVR)/Integrated Web Response (IWR) ... allows users to design and deploy clinical trial Integrated Response ... of clinical trials. This time and cost savings stems from ...
... , , , , ... /PRNewswire-Asia-FirstCall/ -- Tianyin,Pharmaceutical Co., Inc., (NYSE Amex: TPI ), ... Western Pharmaceuticals,based in Chengdu, China , today announced that ... of Pricing Mechanism of Medicine,and Medical Services by the Chinese ...
... ... Divergence and National Corn Growers Association continues collaboration. , ... (PRWEB) February 9, 2010 -- Divergence, Inc. announced ... totaling $500,000, along with renewed funding from the National Corn Growers Association (NCGA), to ...
Cached Biology Technology:endpoint Saves Money and Time for Medical Research Teams Through PULSE 2endpoint Saves Money and Time for Medical Research Teams Through PULSE 3Tianyin Pharmaceutical Co., Inc. Expects to Benefit from the Recently Published Guide to Pricing Reform for Medicine and Medical Services 2Tianyin Pharmaceutical Co., Inc. Expects to Benefit from the Recently Published Guide to Pricing Reform for Medicine and Medical Services 3New Funding Validates Importance of Divergence's Work on Nematodes 2New Funding Validates Importance of Divergence's Work on Nematodes 3
Fluorescence Preserving Media, 100 mL...
Antibodies were affinity purified using epitopes specific to XLF immobilized on solid support....
...
... Clone/PAD: 3B8A10. Immunogen: ... the C-terminal region of ... Specific for the human ... Human (positive control: 293 ...
Biology Products: