Navigation Links
Zebrafish may hold key to improved cancer research

A new study has confirmed that research done with zebrafish may be able to play a critical role in learning about the genetic basis of cancer and the mutations that can lead to it - and identified one gene in particular, B-myb, whose function is essential to preventing tumors.

The findings were published in a professional journal, Proceedings of the National Academy of Sciences, by researchers from Oregon State University and two Boston hospitals, the Brigham and Women's Hospital and Children's Hospital.

The research also indicates that zebrafish may be a key to faster, less expensive studies on cancer and carcinogens, as well as a tool to lower the cost for drug development, OSU experts said.

The first comprehensive cancer research studies using this small, striped tropical fish were begun at OSU over 10 years ago, and the species has become an important tool in medical research programs around the world.

"It's increasingly clear that in zebrafish we have an animal model that is inexpensive, easy to work with and extremely useful for study of human cancers," said Jan Spitsbergen, a fish pathologist in OSU's Center for Fish Disease Research. "We've now proven that most of the carcinogens that affect humans are also active in zebrafish and can lead to the same types of cancer, whether it's in the brain, blood, reproductive organs or elsewhere."

The newest finding about the gene B-myb is especially compelling, said Spitsbergen. The B-myb gene has been conserved through hundreds of millions of years of divergent evolution in species ranging from worms to fruit flies, fish and humans.

When it functions normally, B-myb appropriately regulates cell proliferation. When it becomes mutated, either through genetic predisposition or environmental influences, the formation of tumors can dramatically increase, scientists say. The gene appears to be particularly relevant to human leukemias.

OSU's fish disease research program
'"/>

Source:Oregon State University


Page: 1 2 3

Related biology news :

1. Zebrafish may hold key to understanding human nerve cell development
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Scientists discuss improved biopesticides for locust control in West Africa
4. Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
5. Novel method reveals how menthol discovery could point towards new or improved pain therapies
6. UF scientists test improved gene therapy method for hereditary heart conditions
7. Report calls for improved monoclonal antibodies against solid tumors
8. End-of-life care can be improved
9. Viral DNA sequence a possible trigger for breast cancer
10. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
11. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Zebrafish may hold key improved cancer research

(Date:8/5/2015)... 5, 2015 According to a ... Market by Software, Services, Vertical (BFSI, Airport, IT & Telecom, ... Global Forecast to 2020", published by MarketsandMarkets, defines and ... into various segments. The global PIAM Market is estimated ... Million by 2019, at a CAGR of 14.9 % ...
(Date:8/4/2015)... , Aug. 04, 2015 ... http://www.researchandmarkets.com/research/nvh7k2/digital_forensics ) has announced the addition of ... (Hardware, Software, and Service), Sub-Segment (Computer Forensics, ... Forensics), Tool Types, Service, Vertical and Region ... to their offering. By Component ...
(Date:7/31/2015)... -- Den 10. internationale konference om Genomik (ICG-10, ... 25. oktober i Shenzhen , Kina. ... år. Siden starten i 2006 er ICB blevet en ... er en af de mest dynamiske, entusiastiske og sjove ... gennembrud og fremskridt inden for ,omik,-forskning, som yderligere vil ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... described fossil whales---a pregnant female and a male of the ... insights into how whales made the transition from land to ... 2000 and 2004 and studied at the University of Michigan, ... online journal PLoS . U-M paleontologist Philip Gingerich, ...
... In 2005, a woman who had trouble sleeping asked ... sleep disorders specialist at the Mayo Clinic campus in ... interrupts sleep because of unpleasant sensations in the legs ... relieved by movement. Restless legs syndrome affects ...
... State University already have shown that gardening can offer enough ... In research to be published in February in the journal ... health benefits of gardening is keeping older hands strong and ... older adults who are gardeners have better hand strength and ...
Cached Biology News:Early whales gave birth on land, fossil find reveals 2Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family 2Gardening gives older adults benefits like hand strength and self-esteem 2
(Date:9/3/2015)... Texas , Sept. 3, 2015  Vermillion, Inc. ... on gynecologic disease, today announced that Herbert Fritsche ... subsidiary, ASPiRA LABS, is the recipient of the 2015 ... and Biomarkers (ISOBM) for outstanding contributions to the field ... the award on October 5 th in Zakopane, ...
(Date:9/3/2015)... PUNE, India , September 3, 2015 ... "Chromatography Instruments Market by System (LC (HPLC, UHPLC, Flash), ... (Reverse Phase Columns, Syringe Filters, Vials) - Analysis & ... Instruments Market is expected to reach around 9.223 Billion ... a CAGR of 5.5%. Browse 141 tables ...
(Date:9/3/2015)... MA (PRWEB) , ... September 03, 2015 , ... If ... conference in Boston this October, you will also want to sign up for ... Sunday, October 18th. The tour includes a walk through of the (8) chemistry ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... compliance, quality systems, analytical testing, education and consulting services for the medical ... medical device products/processes development, design control, validation, quality assurance and regulatory compliance. ...
Breaking Biology Technology:Vermillion Announces Dr. Herbert Fritsche as Recipient of the 2015 Abbott Award from the International Society of Oncology and Biomarkers 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 4Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7
... Orange ... Fraxel and Thermage) as the keynote speaker for a special physician to physician forum. ... a close time span. Dr. Pilest was chosen because of his reputation among his ... ...
... By applying cutting-edge techniques in single-molecule manipulation, researchers ... that the body uses to regulate the clotting of ... physical, quantitative, and predictive model of how the body ... treatment of bleeding disorders. A team, co-led by ...
... SUNNYVALE, Calif., June 5 Pharmacyclics, Inc. (Nasdaq: ... innovative small molecule drugs for the treatment of immune mediated ... COO will present on Wednesday, June 10, at 11:30 a.m. ... place at the New York Palace Hotel. , , ...
Cached Biology Technology:Orange County Laser Surgeon Nissan Pilest Tapped as Keynote Speaker at Fraxel & Thermage User Forum Held at Beckman Laser Institute 2Orange County Laser Surgeon Nissan Pilest Tapped as Keynote Speaker at Fraxel & Thermage User Forum Held at Beckman Laser Institute 3Researchers solve 'bloodcurdling' mystery 2Pharmacyclics to Present at the 8th Annual Needham and Company Life Sciences Conference 2
... electrophoretic mobility shift assay (EMSA) is a ... referred to as gel shift or gel ... principle that when subjected to electrophoresis, free ... complex. The Pierce LightShift Chemiluminescent EMSA Kit ...
... Cytomics FC 500 Series is ... with the most advanced technologies ... delivers flexible testing, powerful software ... that help researchers optimize their ...
... of a protein into cells permits studies ... pathways, apoptotic pathways, and transcription factor-mediated gene ... the effects of a specific protein in ... protein directly into the cell. ProteoJuice Protein ...
Reacti-Bind DNA Coating Solution...
Biology Products: