Navigation Links
Yeast Network Prevents Damage By Oxygen Radicals

Reactive oxygen species (ROS), or 'oxygen radicals', have been identified as major contributors to signs of premature aging, increased cancer prevalence linked to inflammation-associated syndromes and a variety of human diseases. Now scientists at the University of California, San Diego Branch of the Ludwig Institute for Cancer Research (LICR) have identified a key network of DNA repair and cell cycle control genes in yeast that prevents the deleterious effects of ROS.

"DNA repair and cell cycle control mechanisms are important guardians against cancerous changes in human cells," says Dr. Richard Kolodner, LICR Member and senior author of the study. "However, the effects of ROS on these cellular responses have not been well characterized. We've now identified a group of genes that cooperate to suppress DNA mutations and the genome rearrangements that are the hallmarks of cancer cells that occur in response to ROS."

Dr. Kolodner and lead author, Meng-Er Huang, generated various yeast strains each with a mutation in the TSA1 gene, which results in increased production of ROS, plus a mutation in one or more genes involved in DNA repair or cell cycle control. Cell survival and accumulation of DNA mutations and gross chromosomal rearrangements in each strain were then analysed to identify genes that cooperate to prevent the deleterious effects of ROS and promote normal cell survival.

"These results suggest that endogenous ROS-induced genome instability may contribute to cancer progression," says Dr. Kolodner, professor of medicine with UCSD School of Medicine and member of the Rebecca and John Moores UCSD Cancer Center. "And increased ROS is almost certainly more harmful in cells with acquired mutations in other genes in the network. However the connections we've found might point to new strategies, like dietary supplements, that will alleviate some of the clinical symptoms of human diseases associated with genetic deficiencies of DNA damage respon
'"/>

Source:Ludwig Institute For Cancer Research


Page: 1 2

Related biology news :

1. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
2. Computational Method Speeds Mapping of Cell Signaling Networks
3. Active Vaccine Prevents Mice From Developing Prion Disease
4. Research Gives Hope For Liver Damage
5. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
6. South African Tribunal Asks For Damages Estimates in GSK AIDS Drug Case
7. New Look at DNA Hints at Origin of UV Damage
8. Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
9. Oxygen increase caused mammals to triumph, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Yeast Network Prevents Damage Oxygen Radicals

(Date:7/11/2014)... at the Department of Energy,s Oak Ridge National ... by R&D Magazine in recognition of the year,s ... the tremendous value of our National Labs," said ... at the National Labs continues to help our ... scientific and technological innovations necessary to remain globally ...
(Date:7/11/2014)... German . ... refraction of X-rays through a specimen instead of attenuation ... are often of much higher quality than those based ... Franz Pfeiffer are particularly interested in developing new approaches ... phase-contrast imaging. One main goal is to make this ...
(Date:7/11/2014)... other group members to reduce aggression and gain access ... for grooming activities shows a certain pattern across the ... journal Biology Letters . , Grooming between individuals ... ulterior motives. To be groomed has hygienic benefits and ... individual can provide access to infants, mating opportunities and ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4New simple setup for X-ray phase contrast 2Baboons groom early in the day to get benefits later 2
... against nature when scientists succeeded in creating a new ... naturally occurring enzyme has evolved. This achievement opens the ... applications in medicine and industry. Enzymes are, ... intricate works of nature. These molecular machines which ...
... Over two hundred million humans depend for their subsistence on ... - and orders its partners, the symbiotic algae, to make ... delicate and complex partnerships a collaboration now facing grave ... a primitive animal and zooxanthellae, tiny one-celled plants, is ...
... RELEASE Toward a new generation of vaccines ... Chemical Research Researchers in Colombia, South America, ... of synthetic vaccines that could lead to more effective ... diseases. These conditions kill more than 17 million people ...
Cached Biology News:Birth of an enzyme 2Birth of an enzyme 3Coral's addiction to 'junk food' 2Coral's addiction to 'junk food' 3American Chemical Society's Weekly PressPac -- March 19, 2008 2American Chemical Society's Weekly PressPac -- March 19, 2008 3American Chemical Society's Weekly PressPac -- March 19, 2008 4American Chemical Society's Weekly PressPac -- March 19, 2008 5American Chemical Society's Weekly PressPac -- March 19, 2008 6American Chemical Society's Weekly PressPac -- March 19, 2008 7American Chemical Society's Weekly PressPac -- March 19, 2008 8American Chemical Society's Weekly PressPac -- March 19, 2008 9
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a firm ... today announced that it has acquired the Slim-Fast brand ... the business. Terms of the transaction were not disclosed. ... meal replacement business that markets ready-to-drink shakes, powders, bars ... America and in the United ...
(Date:7/10/2014)... -- According to the International Atomic Energy Agency ... from terrorists acquiring sufficient quantities of plutonium or ... nuclear explosive device. The IAEA also notes that ... gram-level quantities, which can be challenging to detect ... new study appearing this week in the ...
(Date:7/10/2014)... been extremely challenging because there are many genetic variants ... disease. Now investigators reporting in the July 3rd issue ... describe a strategy that may help reveal how ... or environmental exposures to affect the development of the ... may predispose individuals to schizophrenia. , The work ...
(Date:7/10/2014)... for crude 3-D glasses, polarized glasses, and shutter ... devices, used to trick the brain into perceiving ... obsolete with the introduction of new holography technology ... doctoral students Yuval Yifat, Michal Eitan, and Zeev ... nanoantennas that could be used for security as ...
Breaking Biology Technology:Kainos Capital Acquires Slim-Fast From Unilever 2Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... 2012 The National Foundation for Cancer Research announced ... have been awarded the 7th annual Szent-Gyorgyi Prize for ... led to the successful development of a new therapeutic ... By combining traditional Chinese medicine with Western medicine, Drs. ...
... University of Pennsylvania research team have shown that they can ... Pigmentosa, or XLRP, in dogs. The disease in humans ... and results in early, severe and progressive vision loss. It ... degeneration in man. "Every single abnormal feature that ...
... is largely transparent to the eye and, as it turns ... by scientists at Rice University and Rensselaer Polytechnic Institute (RPI) ... wet when clad by a single continuous layer of graphene ... in the online edition of Nature Materials , is ...
Cached Biology Technology:Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research 2Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research 3Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research 4Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research 5Gene therapy research from Penn Vet & Scheie Eye Inst. cures retinitis pigmentosa in dogs 2Gene therapy research from Penn Vet & Scheie Eye Inst. cures retinitis pigmentosa in dogs 3Water sees right through graphene 2