Navigation Links
Yeast Network Prevents Damage By Oxygen Radicals

Reactive oxygen species (ROS), or 'oxygen radicals', have been identified as major contributors to signs of premature aging, increased cancer prevalence linked to inflammation-associated syndromes and a variety of human diseases. Now scientists at the University of California, San Diego Branch of the Ludwig Institute for Cancer Research (LICR) have identified a key network of DNA repair and cell cycle control genes in yeast that prevents the deleterious effects of ROS.

"DNA repair and cell cycle control mechanisms are important guardians against cancerous changes in human cells," says Dr. Richard Kolodner, LICR Member and senior author of the study. "However, the effects of ROS on these cellular responses have not been well characterized. We've now identified a group of genes that cooperate to suppress DNA mutations and the genome rearrangements that are the hallmarks of cancer cells that occur in response to ROS."

Dr. Kolodner and lead author, Meng-Er Huang, generated various yeast strains each with a mutation in the TSA1 gene, which results in increased production of ROS, plus a mutation in one or more genes involved in DNA repair or cell cycle control. Cell survival and accumulation of DNA mutations and gross chromosomal rearrangements in each strain were then analysed to identify genes that cooperate to prevent the deleterious effects of ROS and promote normal cell survival.

"These results suggest that endogenous ROS-induced genome instability may contribute to cancer progression," says Dr. Kolodner, professor of medicine with UCSD School of Medicine and member of the Rebecca and John Moores UCSD Cancer Center. "And increased ROS is almost certainly more harmful in cells with acquired mutations in other genes in the network. However the connections we've found might point to new strategies, like dietary supplements, that will alleviate some of the clinical symptoms of human diseases associated with genetic deficiencies of DNA damage respon
'"/>

Source:Ludwig Institute For Cancer Research


Page: 1 2

Related biology news :

1. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
2. Computational Method Speeds Mapping of Cell Signaling Networks
3. Active Vaccine Prevents Mice From Developing Prion Disease
4. Research Gives Hope For Liver Damage
5. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
6. South African Tribunal Asks For Damages Estimates in GSK AIDS Drug Case
7. New Look at DNA Hints at Origin of UV Damage
8. Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
9. Oxygen increase caused mammals to triumph, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Yeast Network Prevents Damage Oxygen Radicals

(Date:8/28/2014)... TX Invasives is now available from the Lady Bird ... Austin for identifying harmful non-native plant, insect and other ... United States cause about $137 billion in economic and ... waterways, kill native plants and more. , "By having ... where invasive species occur, we,re more likely to catch ...
(Date:8/28/2014)... German . The ... a striking pattern of blue stripes alternating with golden stripes. ... and yellow cells emerge during growth in the skin of ... to compose the characteristic colour pattern. ,While it ... to form proper stripes, the embryonic origin of the pigment ...
(Date:8/28/2014)... 2014) Researchers at the University of Minnesota have ... (FSHD) to be used for muscle regeneration research as ... for FSHD. , The research is published in the ... , There is no treatment for FSHD, which is ... of muscular dystrophy. FSHD is an unusual genetic disorder ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3UMN researchers find animal model for understudied type of muscular dystrophy 2
... from the food industry are excellent sources of proteins ... However, at the moment these side streams are mainly ... end up as waste. Coordinated by VTT, the ... containing industrial co-streams) project seeks to enrich several co-stream ...
... is no scientific evidence that low-level electromagnetic field ... causes adverse health effects, according to a report ... the Committee provides advice to authorities about risk ... has assessed the health hazards from low-level electromagnetic ...
... Mass. and COLUMBIA, S.C., Sept. 17, 2012   Eliza Corporation ... engagement management, and BlueCross BlueShield of South Carolina ... rates for BlueCross members increased 45 percent over 2011 ... 2012 program have exceeded expectations in all areas, and ...
Cached Biology News:Food industry's high-quality co-streams used effectively as raw material for new products 2Mobile phones and wireless networks: No evidence of health risk found 2Mobile phones and wireless networks: No evidence of health risk found 3Mobile phones and wireless networks: No evidence of health risk found 4Eliza Corporation and BlueCross BlueShield of South Carolina Drive Awareness and Healthier Behavior to Increase Colorectal Cancer Screenings by 45 Percent 2Eliza Corporation and BlueCross BlueShield of South Carolina Drive Awareness and Healthier Behavior to Increase Colorectal Cancer Screenings by 45 Percent 3Eliza Corporation and BlueCross BlueShield of South Carolina Drive Awareness and Healthier Behavior to Increase Colorectal Cancer Screenings by 45 Percent 4
(Date:8/29/2014)... August 29, 2014 Three Lawrence ... 2014 Hydrogen Production R&D Award for ... splitting water using sunlight. , Shared with collaborators ... the University of Nevada, Las Vegas (UNLV), the ... models of photoelectrochemical solar-hydrogen production and corrosion processes. ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
(Date:8/28/2014)... LAFAYETTE, Ind. A new research platform ... properties of tiny structures undergoing stress and ... to improve designs for microelectronics and batteries., ... reveals information about how heating and the ... mechanical properties. Researchers have discussed the merits ...
(Date:8/28/2014)... -- Next month, executives from clinical trial marketing firm BBK Worldwide ... Patient-Centered Clinical Trials 2014 , to be held at ... September 4-5. Patient recruitment experts Bonnie A. Brescia , ... share insights on the benefits of employing an effective patient ... media to mobile apps – can be used to drive ...
Breaking Biology Technology:Livermore Team Awarded for Hydrogen Production Research 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2
... Ralph Kauten is taking direct aim at three unfavorable metrics, ... test. , ,Kauten, CEO of QBI Life Sciences , ... PreserveX Polymeric Micelles, a core product. The screening, which employed ... and is used to determine whether a drug will become ...
... part of its $6 billion national effort, Cingular Wireless has ... customers in Wisconsin and Illinois. , ,This trend of ... more $300 million in the state and activated more than ... the start of 2006, nine cities have received enhanced coverage, ...
... a Madison-based provider of rich media communications technology, has ... them as podcasts, which can be played on iPods ... audio presentations such as classroom lectures, speeches by experts, ... media formats and downloaded through Mediasite catalogues. These recordings ...
Cached Biology Technology:QBI's PreserveX product passes initial test 2QBI's PreserveX product passes initial test 3
CoverWell imaging chamber gasket with adhesive, one chamber, 20 mm diameter, 1.0 mm deep *set of 40* Cell Biology Imaging Tools and Accessories Microscope Slide Accessories...
Request Info...
RECOMBINANT EQUINE TNF ALPHA Product Type: Recombinant Protein...
... product contains 5 ml of DETACHaBEAD ... from Dynabeads CD19 (Pan B). ... (Pan B) and released with DETACHaBEAD ... Cells are suitable for applications such ...
Biology Products: