Navigation Links
Yale scientists decipher 'wiring pattern' of cell signaling networks

ows several distinct patterns.

"It was a little like having all the pieces of an airplane separated out, and not knowing how those pieces function together to create an airplane and make it fly," said Snyder. "We wanted to know how the tens of thousands of proteins coordinate to carry out complex processes such as growth, cell division and formation of complex cell types such as brain cells and intestinal cells."

Over the past several years, a large volume of information on genes in organisms as diverse as man, mouse, baker's yeast and viruses has been generated. While genomic DNA is the blueprint, the encoded proteins are the products that carry out the complex biological functions of cells. Although scientists can predict from the DNA what proteins are in the proteome of an organism, this study opens the door to seeing how they are coordinated to work together.

"This insight into the regulation and integration of biological networks has broad applications for basic science and clinical research," said Snyder. "Biological networks determine the development and function of organisms from the single-celled yeast to man; aberrations in those networks signal disease."

Biological networks are typically conserved between species, meaning that often the same type of protein carries out the same type of function, whether it is in a yeast cell or a human cell. According to Snyder, these findings in yeast are of immediate use for understanding both human development from the fertilized egg to full grown organism, and for drug discovery targeting human diseases.


'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
(Date:12/15/2009)... organism, but there are currently few resources that ... tissues in this species. A newly released ... Cold Spring Harbor Laboratory Press fills this gap. ... for the preparation, enumeration, and microscopic examination of ... in the mouse. The laboratory manual is ...
(Date:12/14/2009)... -- Researchers at Rice University and Baylor College of ... be tracked in real time with MRI as it ... fluorescent dye and kills them with heat. The all-in-one ... growing field called "theranostics" that develops technologies physicians can ... procedure. , The research is available online in the ...
(Date:12/14/2009)... transmitted by sneezing, touching, or for Tasmanian devils ... that may have driven the dinosaurs to extinction through ... a member of f1000 Biology, highlights the ,paleobiological detective ... One. This led them to deduce that a protozoan ... seen in many tyrannosaurid fossils. , The parasite,s modern-day ...
Breaking Biology News(10 mins):New source of classical techniques for blood-based studies in the laboratory mouse 2Tracking new cancer-killing particles with MRI 2Pennsylvania Schools Report Decrease in Bullying Behaviors 61526 1Pennsylvania Schools Report Decrease in Bullying Behaviors 61526 2Help Boost Your Bodys Defense Against Coughs Colds and the Flu With New Patented vitamingum 28TM 29 Nutrient Enhanced Chewing Gum 61524 1Help Boost Your Bodys Defense Against Coughs Colds and the Flu With New Patented vitamingum 28TM 29 Nutrient Enhanced Chewing Gum 61524 2AMA AARP and MOAA Call for Passage of House Medicare Reform Bill Vote Expected This Week on H R 3961 61521 1AMA AARP and MOAA Call for Passage of House Medicare Reform Bill Vote Expected This Week on H R 3961 61521 2AMA AARP and MOAA Call for Passage of House Medicare Reform Bill Vote Expected This Week on H R 3961 61521 3AMA AARP and MOAA Call for Passage of House Medicare Reform Bill Vote Expected This Week on H R 3961 61521 4
... on computer science and artificial intelligence (AI). For the ... McGovern Institute for Brain Research at MIT applied a ... to a complex, real world task: recognizing the objects ... surprised at the power of this new approach. ...
... male reindeer's air sac, influencing vocal sound and neck contour, ... results of this research have recently been published in Journal ... systems, the voice organs of reindeer differ according to gender. ... and the young. , In early life, growth of ...
... establish a herd of mouflon for sport hunting on a ... inadvertently created a laboratory for genetic researchers and led to ... of generations from a single male and female pair transplanted ... genetic diversity of its founding parents. This finding challenges the ...
Other Biology News:Mimicking how the brain recognizes street scenes 2Mimicking how the brain recognizes street scenes 3Mimicking how the brain recognizes street scenes 4Remote sheep population resists genetic drift 2
(Date:12/15/2009)... /PRNewswire-Asia-FirstCall/ -- China Sky One,Medical, Inc. ("China Sky ... ), a,leading fully integrated pharmaceutical company developing and ... ("PRC"), today,announced that the Company has 30 medicines ... the National Basic Medical Insurance, Industrial Injury Insurance,and ... The 30 medicines treat a variety of ...
(Date:12/15/2009)... CHARLOTTESVILLE, Va., Dec. 15 AstraZeneca ... University of Virginia (UVa) in Charlottesville, today ... strategic research collaboration to enhance development of ... (CAD) with a secondary focus on peripheral ... ) ,, The collaborative preclinical research ...
(Date:12/15/2009)... The International Society for Medical Publication Professionals (ISMPP) ... to accept abstracts for its 6th Annual Meeting, ... 19-21, 2010. This marks the first time that ... organization to submit an abstract to this increasingly ... EST, January 15, 2010. For submission details, please ...
(Date:12/15/2009)... and LONDON, Dec. 15 ... Thomson Pharma ® has become the first drug ... protocol and outcome information. This highly anticipated new ... customers this month. ,, Thomson ... intelligence from registries, publications, press releases, conferences, and ...
Breaking Biology Technology:China Sky Medical, Inc. Has 30 Medicines that will Be Included in China's National Insurance Directory 2China Sky Medical, Inc. Has 30 Medicines that will Be Included in China's National Insurance Directory 3AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 2AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 3The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 2The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 3Thomson Reuters is First to Offer Fully Integrated Pipeline and Clinical Trials 2
... SEKAB has signed an agreement for the supply ... a Brazilian ethanol,and sugar industry leader and part ... agreement safeguards supplies of additional volumes of ethanol,verified ... social,sustainability," says Anders Fredriksson, Executive Vice President, SEKAB,Biofuels ...
... magnet that,s smaller than the head of a pin? , ... MRI technique to do just that. , The technique may eventually ... a new tool for studying the plaques in blood vessels that ... a recent issue of Physical Review Letters, the scientists ...
... This release is available in French . ... . , , A novel super-resolution X-ray microscope developed ... (PSI) and EPFL in Switzerland combines the high penetration power ... the first time to shed light on the detailed interior ...
Other Biology Technology:SEKAB Agreement: More Verified Ethanol to Europe 2New kind of MRI enables study of magnets for computer memory 2New kind of MRI enables study of magnets for computer memory 3Super-resolution X-ray microscopy 2
... arrays have been developed for affinity ... A variety of ProteinChip chemical surfaces ... to their unique biochemical properties. Each ... side-by-side sample comparison, and the chips ...
The Freeze 'N Squeeze DNA gel extraction kit uses a quick freeze-and-thaw cycle and centrifugation to draw 50-23,000 bp DNA out of agarose gel slices. The kit includes materials for 100 preps....
The Econo gradient pump rack is a preassembled rack that is used to hold the components of the Econo gradient pump kits....
... The iCycler thermal cycler with 384-well reaction ... (PCR) applications. It is equipped with an ... and features algorithm temperature monitoring and control ... small sample volumes. It includes the iCycler ...
Biology Products: