Navigation Links
Yale researchers identify molecule for detecting parasitic infection in humans

Researchers at Yale, in collaboration with NIH researchers, have identified a specific protein molecule that is used by the immune system for detection of parasitic infections, leading the way for development of future vaccines to combat these infections.

Published in the April 28 issue of Science Express, the study provides insight into understanding how infectious parasites interface with the immune system--a problem of great scientific and clinical importance.

Most infections are caused by bacterial or viral microorganisms that produce molecules quite different from those produced by humans and other eukaryotic organisms. When microorganisms infect humans, the atypical molecules are usually detected immediately by human proteins called Toll-like receptors (TLR) that alert the human immune system to fight the infection.

But parasites, like humans, are eukaryotic in origin and how the body detects them has been a mystery.

The common parasite Toxoplasma gondii (T. gondii) causing toxoplasmosis, has a complicated life cycle in which it is transmitted from mice to cats and then to humans. Previous research had shown that T. gondii is recognized by a TLR and that the recognition of this parasite is crucial for an appropriate immune response. However, it was unclear which of the 13 different TLRs present in mammals was responsible and which molecule of T. gondii was being recognized by the TLRs.

"In this study we found that the recognition of T. gondii by the innate immune system is mediated by a new member of the TLR family, TLR 11, that we discovered last year," said Sankar Ghosh, professor of immunobiology at Yale School of Medicine. "We further found that the specific recognition molecule was Toxoplasma profilin. The innate immune system has the capacity to recognize these proteins and the profilins are the triggers."

Ghosh said that although parasitic infections are less prominent in the United States than bacterial an d viral infections, the global impact of parasitic infections on health is tremendous. "Insight obtained from these studies should lead to development of novel strategies to combat these infections," he said. "In particular, an understanding of the parasite components that trigger a host immune response may facilitate the development of better vaccines."


'"/>

Source:Yale University


Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. US life expectancy about to decline, researchers say
11. Wisconsin researchers identify sleep gene
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert ... a media edge server, the M820, which features the company,s hybrid ... software provided by Tera Probe, Inc., will be showcased during the ... the NAB show at the Las Vegas ... ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... 21, 2017 , ... The 2017 Colorado Manufacturing Awards celebrates ... nominees and well as the first-year award for 2017 Manufacturing Women of the ... hosted by CompanyWeek and Manufacturers Edge, among other sponsors. , The Colorado ...
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design of the innovative ... introduce it to top lab design architects from around the country at the Lab ... Industrial Design and Engineering Greg Casey will be at the show, where they will ...
(Date:4/21/2017)... Conn. (PRWEB) , ... April 21, 2017 , ... ... (CI) and Webster Bank, today announced first round funding to three startups through ... provide early-stage financial support to new business startups affiliated with UConn. , The ...
(Date:4/21/2017)... and BELLINGHAM, Washington, USA (PRWEB) , ... April ... ... technologies for sensing, imaging, and related applications were the focus of researchers, engineers, ... Commercial Sensing 2017 in Anaheim. , Sponsored by SPIE, the international ...
Breaking Biology Technology: