Navigation Links
Yale researchers find environmental toxins disruptive to hearing in mammals

Yale School of Medicine researchers have new data showing chloride ions are critical to hearing in mammals, which builds on previous research showing a chemical used to keep barnacles off boats might disrupt the balance of these ions in ear cells.

"Our data are the first to directly show that chloride ions are crucial for our exquisite sense of hearing," said Joseph Santos-Sacchi, professor in the Departments of Surgery and Neurobiology and first author of the study in the Journal of Neuroscience."These data also indicate that the hearing in marine and other mammals could be affected by environmental toxins, such as TBT (tributyl tin), because they appear to alter the balance of chloride ions in the outer hair cell."

Sensitive hearing in mammals relies on cochlear amplification resulting from the motor activity of outer hair cells. They are the only group of animals that have outer hair cells. Additionally, TBT is known to damage the immune and hormonal systems of marine mammals.

In this study on guinea pigs, Santos-Sacchi tested whether TBT or salicylate, which is a chemical that occurs naturally in plants and is a component of aspirin, interfered with the guinea pigs' ability to hear. He found that TBT, salicylate, or otherwise altering the extracellular chloride levels in the cochleas, interfered with the balance of chloride in the outer hair cells and caused profound changes in sound amplification in the inner ear.

In his previous study using TBT on isolated cells only, Santos-Sacchi had proposed that the ear's ability to perceive sound would be compromised. He also speculated that whales and other marine mammals exposed to TBT would have altered sound localization abilities. The present findings confirm that their hearing is altered in mammals.

"Since many marine mammals use echolocation or sonar to get around, this could be contributing to whales and dolphins beaching and hitting ships," Santos-Sacchi said.


'"/>

Source:Yale University


Page: 1

Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/6/2017)... 5, 2017  Delta ID Inc., a leader in ... for automotive at CESĀ® 2017. Delta ID has collaborated ... demonstrate the use of iris scanning as a secure, ... driver in a car, and as a way to ... Delta ID and Gentex will demonstrate (booth ...
(Date:12/22/2016)... 22, 2016 SuperCom (NASDAQ:   ... for the e-Government, Public Safety, HealthCare, and Finance sectors announced today ... been selected to implement and deploy a community-based supportive services program ... California , further expanding its presence in the state. ... This new program, which ...
(Date:12/16/2016)... Dec 16, 2016 Research and Markets has ... - Global Forecast to 2021" report to their offering. ... The biometric vehicle ... at a CAGR of 14.06% from 2016 to 2021. The market ... projected to reach 854.8 Million by 2021. The growth of the ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 19, 2017 , ... DaVita Clinical Research ... of drug and device development, and Prism Clinical Research , a leader ... announced Verified Clinical Trials (VCT) has been selected by both companies ...
(Date:1/19/2017)... PLAINVIEW, N.Y. , Jan. 18, 2017 ... pathology services, announces the formation of an Executive Committee ... 2017 and beyond. John Cucci , ... been promoted from Director of Business Development to ... in 2015, Mr. Cucci served in senior sales leadership ...
(Date:1/18/2017)... , January 18, 2017 According to a new ... Diagnosis, Neuroscience, Cytology, Infectious Disease), & End User (Molecular Diagnostic Laboratories, Academic and ... expected to reach USD 739.9 Million by 2021 from USD 557.1 Million in ... Reading ... MarketsandMarkets Logo ...
(Date:1/18/2017)... HACKENSACK, N.J. , Jan. 18, 2017   ... leading the fight to end Duchenne muscular dystrophy ... awarded to the New Jersey Institute of Technology (NJIT) ... ongoing exploration of robotic technology to assist ... study to incorporate NJIT,s technology – an embedded computer, ...
Breaking Biology Technology: