Navigation Links
Yale participates in global human genome initiative

Yale is a founding member of the Genome-Wide RNAi Global Initiative, an alliance of top international biomedical research centers formed to speed scientific and medical discoveries that target genes of the entire human genome. The initiative is sponsored by Dharmacon, Inc., manufacturer of the first complete human genome siRNA library, or compilation of short, interfering ribonucleic acid sequences. The library is designed to determine when individual genes are functioning. It uses a format that is accessible to researchers for detailed analysis of individual genes, gene families and metabolic pathways.

The siRNA sequences have blueprints in DNA and are transcribed, but not translated into proteins. Researchers have recently found that several siRNAs regulate critical gene functions in normal development and in development of cancer.

"Participation in this consortium gives us a cutting-edge technology to systematically screen the human genome using cell-based models of human diseases," said Kevin P. White, associate professor of genetics, ecology and evolutionary biology and the lead investigator for Yale.

The library will be available to the Yale University research community and will be used to screen for human gene functions. "Coupling Yale's expertise in the molecular basis of human disease with access to this siRNA library has a tremendous potential for discoveries that will lead to better diagnostic and therapeutic solutions for a wide variety of diseases, including most forms of cancer," said White.

Founding members of the Global Initiative have a broad spectrum of biomedical research interests that will provide a forum for sharing research protocols, establishing experimental standards and developing ways to exchange and compare data. The continu ed interaction is expected to help optimize rapid, genome-wide screening and accelerate drug discovery.

The other Global Initiative founding member institutions are the Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital and the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in collaboration with the University of Toronto; the Cancer Research UK (CRUK)-funded scientists at the LondonResearch Institute and the Institute of Cancer Research; the German Cancer Research Center (DKFZ); the University of Nebraska Medical School; the Netherlands Cancer Institute; the Scottish Centre for Genomic Technology and Informatics based at the University of Edinburgh Medical School and University of Texas Southwestern Medical Center.

The membership of the Global Initiative is expected to expand further as additional not-for-profit research institutions from North America, Europe and Asia join in the coming months. Its first meeting will take place in Boston on October 17-18, 2005.


Source:Yale University

Related biology news :

1. Scientists collaborate to assess health of global environment
2. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
3. DuPonts first biologically derived polymer receives global recognition
4. Virus-host interactions at sea effect global photosynthesis
5. Hopkins AIDS experts issue warning about global efforts to provide drug therapies
6. Scientists discover global pattern of big fish diversity in open oceans
7. AIDS expert says global strategy needed to combat feminization of HIV/AIDS
8. Marine bacterium suspected to play role in global carbon and nitrogen cycles
9. Errors in the measurement of global warming corrected
10. Clean skies=faster global warming?
11. Storing carbon to combat global warming may cause other environmental problems, study suggests
Post Your Comments:

(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:3/30/2017)... 2017  On April 6-7, 2017, will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics ( ) has launched Rosalindâ„¢, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... 11, 2017 , ... The CRISPR-Cas9 system has ... and avoiding the use of exogenous expression plasmids. The simplicity of programming this ... gain-of-function studies. , This complement to loss-of-function studies, such as with RNAi ...
(Date:10/11/2017)... CA, USA (PRWEB) , ... October 11, 2017 , ... ... to take place on 7th and 8th June 2018 in San Francisco, CA. The ... influencers as well as several distinguished CEOs, board directors and government officials from around ...
(Date:10/11/2017)... 11, 2017  VMS BioMarketing, a leading provider of patient ... Clinical Nurse Educator (CNE) network, which will launch this week. ... among health care professionals to enhance the patient care experience ... and other health care professionals to help women who have ... ...
Breaking Biology Technology: