Navigation Links
Yale biologists 'trick' viruses into extinction

While human changes to the environment cause conservation biologists to worry about species extinction, Yale biologists are reversing the logic by trying to trap viruses in habitats that force their extinction, according to a report in Ecology Letters.

To avoid going extinct a population must not only survive, but also reproduce. Paul Turner, associate professor of ecology and evolutionary biology at Yale, tested the practicality of luring a virus population into the wrong cells within the human body, thus preventing virus reproduction and alleviating disease.

"Ecological traps for viruses might arise naturally, or could be engineered by adding viral binding sites to cells that disallow virus reproduction," said senior author Turner. "We proved the concept using a non-human virus, and variants of the bacteria cells it infects."

In ecology, a habitat that supports population growth is termed a "source," whereas a non-supportive habitat is a "sink." This study reported on the success of phi-6 virus populations in environments containing different mixtures of ordinary "source" bacteria and mutant trap cells that act as "sinks."

Their research showed that when the number of trap cells exceeded a key threshold in the mixtures, the virus population could no longer sustain itself and declined toward extinction.

"This approach has intriguing potential for new treatments against human viruses," said Turner. "A similar idea already exists in agriculture, where farmers use non-harvested 'trap crops' to lure insect pests. Because the pests prefer the taste of the trap crops, only these plants need to be sprayed, reducing the amount of pesticide use."

Turner believes that similar trickery might be used against human viruses like HIV. He notes that HIV recognizes the T-cells it infects by CD4 molecules on the cell surf ace, but it then requires functions of the cell nucleus to reproduce. Current anti-HIV therapies are designed to maintain high T-cell counts in the human body, so that the immune system can properly function. But, these drugs therapies are very expensive.

Turner suggests, "A cheaper option is the possibility of engineering trap cells that have CD4 molecules on their surface, but no nucleus for virus reproduction. Mature red blood cells could fill the bill, because they lack a nucleus and could be engineered as sink habitats that greatly outnumber the T-cell source habitats in the body."


'"/>

Source:Yale University


Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. NYU biologists map out early stages of embryo formation
4. FSU biologists describe key role of signal-transcribing gene during cell cycle
5. High-tech tags on marine animals yield valuable data for biologists and oceanographers
6. UCSD biologists find new evidence for one-way evolution
7. UC San Diego biologists solve plant growth hormone enigma
8. FSU biologists uncover mechanisms that shape cells for better or worse
9. NYU biologists identify gene that coordinates two cellular processes
10. MIT biologists solve vitamin puzzle
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of ... the latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Medical Display- Ampronix News ...
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com ... just published the overview results from the Q1 wave ... the recent wave was consumers, receptivity to a program ... data with a health insurance company. "We ... to share," says Michael LaColla , CEO of ...
(Date:4/28/2016)... and BANGALORE, India , April 28, ... Systems, a product subsidiary of Infosys (NYSE: INFY ... announced a global partnership that will provide end ... use mobile banking and payment services.      (Logo: ... key innovation area for financial services, but it also plays ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers ... 5000 and the 6000i models are higher end machines that use the more unconventional ... spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci has ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
Breaking Biology Technology: