Navigation Links
Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

Research in the laboratory of Assistant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in March issues of the journals Cell and Developmental Cell.

The oncogene Ras is out of control in about 20 percent of cancers where it is over-expressed or activated by mutation. According to Slack, a member of the Yale Cancer Center, it is one of the most identifiable causes in some forms of lung cancer. His team has identified let-7, a natural and separately transcribed RNA that maps to a chromosomal region associated with lung cancer as a regulator of Ras expression.

DNA of plants and animals contains sequences encoding microRNAs, important regulators of development, that control processes determining cell type and cell death.

"The let-7 microRNA regulates Ras by binding to the message for Ras and likely inhibits translation of the Ras protein," said Slack. "The microRNA does not revert a mutated Ras to normal; instead it acts like a brake on an accelerated Ras."

Lung cancer currently has a poor prognosis with less than 15 percent of patients surviving five years. The lungs, however, are relatively accessible for inhalation of potential gene therapy agents. "While this is not likely to cure the cancer," said Slack, "after diagnosis, gene therapy with let-7 may be a way to alleviate or slow it down."

This work arose from Slack's basic research in the department of molecular, cellular and developmental biology on the nematode round worms, C. elegans. He found that these worms require let-7 RNA for normal development to occur. Without it, cells do not stop dividing and fail to differentiate into the normal structures of the worm ?instead they make an excess of their cells.

After identifying let-7 as a cell division regulator, Slack's team used bioinformatics and found the relationship
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Scientists collaborate to assess health of global environment
7. Scientists decipher genome of fungus that can cause life-threatening infections
8. Scientists discover the cellular roots of graying hair
9. Scientists rid stem cell culture of key animal cells
10. Scientists develop new color-coded test for protein folding
11. Scientists identify genetic pathways essential to RNA interference
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

(Date:7/31/2015)... , July 31, 2015 The 10 th ... held by BGI from October 22-25, 2015, in Shenzhen ... The conference is celebrating its 10 th anniversary this year. ... the world,s most influential annual meetings in the ,omics, fields, ... scientific gatherings. ICG-10 focuses on recent breakthroughs ...
(Date:7/27/2015)... 2015   Zynx Health ™, the market ... solutions, today announced that its ZynxCarebook ™ ... Android smartphones and tablets. With this expansion, care ... use ZynxCarebook to securely exchange messages and share ... transitions to other care settings, and improve clinical ...
(Date:7/21/2015)... Sweden , July 21, 2015 Today, ... FPC1025. Already received as well as expected revenues in 2015 that ... in FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a leading smartphone manufacturer in China ... selected FPC1 02 5 for Axon ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... Rensselaer Polytechnic Institute have found a new pathway by which ... from the National Institutes of Health, they plan to fill ... a surface, which could lead to a better understanding of ... of organisms. , Cells must interact with each other to ...
... techniques, researchers at Georgetown University Medical Center have watched how ... novel tasks, an advance they say may help speed up ... to retrain people with perceptual deficits due to autism. , ... research team provides the first human evidence for a two-stage ...
... an ancient line of aquatic plants previously thought to be ... be one of the biggest misunderstandings in botanical history. ... Graham, an associate professor and researcher with the UBC Botanical ... Land and Food Systems. "And it took DNA sequence evidence ...
Cached Biology News:New molecular pathway could reveal how cells stick together 2Using brain scans, researchers find evidence for a two-stage model of human perceptual learning 2Using brain scans, researchers find evidence for a two-stage model of human perceptual learning 3UBC researchers reveal dwarf aquatic plants' hidden ancestry 2
(Date:7/30/2015)... Dallas, Texas (PRWEB) , ... July 30, 2015 , ... ... professional and in-depth study on the current state of the global Propanol market with ... are Sinopec, CNPC, BASF, Eastman, Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal ...
(Date:7/30/2015)... 2015   Senomyx , Inc. (NASDAQ: SNMX ... to discover, develop, and commercialize novel flavor ingredients for ... financial results for the second quarter 2015. ... remain on track to achieve our commercial and financial ... of the Company. "Since our last quarterly earnings report, ...
(Date:7/30/2015)... WARRINGTON, Pa. , July 30, 2015 /PRNewswire/ ... announced that it has received the second $1.0M ... Business Innovation Research (SBIR) grant valued at up ... the company,s aerosolized KL4 surfactant as a potential ... lung injury.  Discovery Labs was awarded an initial ...
(Date:7/29/2015)... 2015 Sanofi, un leader ... résultats pour le premier semestre 2015. Le Directeur ... Visionner l,interview vidéo et lire la ... Au sommaire de l,interview :  ... croissance - Diabète - ...
Breaking Biology Technology:Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... (Amex: ILE ) today announced that on ... (the "Exchange") notifying the Company it is not in ... (the "Company Guide"). Specifically, the Exchange staff noted that ... relation to its overall operations or its existing financial ...
... March 20 On Wednesday, April 29, 2009, Wyeth (NYSE: ... 2009 first quarter. The Company will hold a forty-five minute ... on April 29, 2009. Interested investors and others may ... through our Internet webcast, which may be accessed by visiting ...
... and textile processingPALO ALTO, Calif., March 20 ... a division of Danisco A/S, hosted a private ... headquarters to a group of industry influencers and ... for developing sustainable fuels, chemicals, and other products ...
Cached Biology Technology:Isolagen, Inc. Receives Notification Letter from Amex 2Isolagen, Inc. Receives Notification Letter from Amex 3Isolagen, Inc. Receives Notification Letter from Amex 4Wyeth Sets Webcast and Conference Call for 2009 First Quarter Earnings 2Genencor Shows How Industrial Biotech Breakthroughs Contribute to the New Green Economy 2Genencor Shows How Industrial Biotech Breakthroughs Contribute to the New Green Economy 3
Sprague Dawley rats, 7-8 weeks of age, mixed gender; collected by exsanguination in Alsever's solution at 1:2 dilution...
... S.c. EasyComp Transformation Kit is designed ... cerevisiae cells. Advantages over commonly used ... or LiCl methods include:- Cells can be ... minutes - Competent cell preparation and transformation ...
Trop-2 Purified Anti-Human clone 162-46, Isotype Mouse IgG 1 , 100 µg Consult technical datasheet for details....
... Error-free cloning of BAC (100+kb), fosmid ... Greater insert stability than any othe BAC ... for high yields and easy recombinant DNA ... or transcription-free (pSMART VC) vectors for the ...
Biology Products: