Navigation Links
Xie Lab demonstrates the role of microRNA pathway

Ting Xie, Ph.D., Associate Investigator, and Zhigang Jin, Ph.D., Postdoctoral Research Associate in the Xie Lab, have published results showing that the microRNA pathway is essential for controlling self-renewal of germline stem cells and somatic stem cells in the Drosophila ovary.

The paper, "Dcr-1 Maintains Drosophila Ovarian Stem Cells," was published on the Web site of Current Biology today.

MicroRNAs are single-stranded small RNA molecules believed to regulate the expression of other genes. The Xie Lab's findings show that the microRNA pathway is essential for controlling self-renewal of two types of stem cells in the Drosophila ovary.

"The findings were interesting to us because they demonstrated that the microRNA pathway is essential for controlling self-renewal or maintenance of two types of stem cells —germline stem cells and somatic stem cells," said Dr. Jin. "In the future, the small RNAs responsible for stem cell regulation could potentially be used to control stem cell functions in vivo and stem cell expansion in vitro."

"We are in the process of identifying the microRNAs that are important for stem cell self-renewal," said Dr. Xie. "Understanding the mechanisms controlling stem cell self-renewal will be crucial to our developing the ability to expand stem cell populations for performing tissue repair."


'"/>

Source:Stowers Institute for Medical Research


Page: 1

Related biology news :

1. MRSA study demonstrates need for frequent hand washing and environmental disinfection in health care settings
2. Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
3. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
4. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
5. Molecular steps involved in the creation of gene-silencing microRNAs identified
6. Scientists find microRNAs regulate plant development
7. Role of microRNA identified in thyroid cancer
8. Twin molecular scissors link creation of microRNAs with gene-silencing
9. Single microRNA causes cancer in transgenic mouse
10. Activation of microRNA inhibits cancer gene in human cancer cells
11. Pair of microRNA molecules controls major oncogene in most common leukemia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time in ... STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, ... , US2020’s mission is to change the trajectory of STEM education in America ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology: