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Woven scaffolds could improve cartilage repair

sue engineering," Moutos said.

"Once implanted, the cartilage cells will grow throughout the scaffold, and over time the scaffold will slowly dissolve, leaving the new cartilage tissue" he said. "The use of this scaffold will also permit doctors to treat larger areas of cartilage damage, since the current approaches are only suitable for repairing smaller areas of cartilage damage or injury."

Cartilage is a type of connective tissue that lines the ends of bones, providing cushioning and a smooth surface for their movement within the joint. Damage to cartilage is difficult to treat, the researchers said, because the tissue lacks a supply of blood, nerve and lymph and has limited capacity for repair.

Current strategies for treating cartilage damage, such as surgery or cartilage implants, are fairly limited, said Farshid Guilak, Ph.D., director of orthopedic research at Duke and senior member of the research team.

"We don't currently have a satisfactory remedy for people who suffer a cartilage-damaging injury," Guilak said. "There is a real need for a new approach to treating these injuries. One of the beauties of this system is that since the cells are from the same patients, there are no worries of adverse immune responses or disease transmission.

"The scaffold will give surgeons the opportunity to treat their patients immediately, while patients won't have to wait for months with their painful joint," Guilak said.

Most machines that produce fabrics weave one set of fibers that are oriented perpendicularly to another set of fibers. However, the machine that Moutos developed adds a third set of fibers, which creates a three-dimensional product. Also, since the scaffold is a woven material, there are tiny spaces where cartilage cells can nestle and grow.


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Source:Duke University Medical Center


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