Navigation Links
Worm links cancer risk to ageing

The reason why people are at greater risk of developing cancer as they get older may be explained by research published today (June 2).

Scientists have discovered that a naturally produced protein that helps protect us from cancer may also determine how long we live.

The findings ?published in the highly respected journal Science ?open up a new avenue of inquiry into ageing as a risk factor for cancer.

"We have discovered that proteins that prevent cancer in humans by ensuring that cells don't divide if they are damaged also determine lifespan in the nematode worm," explained Professor Gordon Lithgow, who carried out the work at The University of Manchester.

"Our research has shown that these 'checkpoint proteins' ?thought only to operate in cells that divide ?function in cells that no longer divide as well. The fact that they appear to have dual functions opens a new way to study the connection between ageing and cancer."

Scientists have long known that, statistically, ageing is a huge factor for cancer but have so far struggled to understand why that is.

Professor Lithgow said: "If we look at checkpoint proteins as a gear, we have known for a long time that they drive the cancer engine; now we know that they also drive the longevity engine. This discovery has exciting potential as an area of inquiry into potential cellular links between ageing and cancer."

The research, which was completed at the Buck Institute in California where Dr Lithgow now works, involved genetically removing checkpoint proteins in the microscopic worm C. elegans. By doing so, the researchers caused a 15-30% increase in the worm's lifespan.

"Given the role that checkpoint proteins play in the development of cancer ?or in causing tumours when the proteins are defective ?the findings raise the question of whether genetic variations in these proteins in humans places some individuals at risk of cancer.

"Conversely, the check point proteins may set a genetic course for a shorter life but one that is free from cancer."

Dr Dale Bredesen, Chief Executive and Scientific Director at the Buck Institute, added: "This work brings a new richness and sophistication to the way we think about longevity interventions.

"If we're smart about it, we might be able to design strategies where you could keep checkpoint proteins active in dividing cells and stop them working in cells that no longer divide, such as brain cells.

"Increasing the survival of brain cells or 'neurons' could provide a new avenue of treatment for neurodegenerative diseases like Alzheimer's."


'"/>

Source:University of Manchester


Related biology news :

1. NASA links nanobacteria to kidney stones and other diseases
2. Insight into DNAs weakest links may yield clues to cancer biology
3. One gene links newborn neurons with those that die in diseases such as Alzheimers
4. Genetic links could unlock clues to leading cause of blindness
5. Climate model links higher temperatures to prehistoric extinction
6. Genetics links whale to two different ocean basins
7. Scientists discover a genetic switch that links animal growth and cancer
8. Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
9. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
10. Queensland scientists identify molecule that links both sides of the brain
11. Study links high levels of nitric oxide to infertility and sperm DNA damage
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... ... 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma ... treated over 100 of their own patients with the VetStem Cell Therapy. Each of ... care for their patients. , The veterinarians are Dr Ross Rich former owner ...
(Date:5/19/2016)... ... May 19, 2016 , ... Anton Paar USA, located ... foot office building is complete. The new structure adds a third office building to ... Paar USA purchased 2.4 acres of land, along with office space adjacent to ...
(Date:5/19/2016)... SAN DIEGO , May 19, 2016 /PRNewswire/ ... (OTCBB: RGBP), (OTC PINK: RGBP) and (OTC PINK: RGBPP) announced ... at creating the first cord blood based cancer ... a provisional patent application, Regen described a generation ... activity was potentiated by gene silencing.  The product ...
(Date:5/18/2016)... YORK , May 18, 2016 ... but it does not mean that there are no opportunities ... Threshold Pharmaceuticals Inc. (NASDAQ: THLD ), Seattle Genetics ... CHMA ), and Ophthotech Corp. (NASDAQ: OPHT ... trading alerts at: http://www.activewallst.com/ ...
Breaking Biology Technology: