Navigation Links
Worm links cancer risk to ageing

The reason why people are at greater risk of developing cancer as they get older may be explained by research published today (June 2).

Scientists have discovered that a naturally produced protein that helps protect us from cancer may also determine how long we live.

The findings ?published in the highly respected journal Science ?open up a new avenue of inquiry into ageing as a risk factor for cancer.

"We have discovered that proteins that prevent cancer in humans by ensuring that cells don't divide if they are damaged also determine lifespan in the nematode worm," explained Professor Gordon Lithgow, who carried out the work at The University of Manchester.

"Our research has shown that these 'checkpoint proteins' ?thought only to operate in cells that divide ?function in cells that no longer divide as well. The fact that they appear to have dual functions opens a new way to study the connection between ageing and cancer."

Scientists have long known that, statistically, ageing is a huge factor for cancer but have so far struggled to understand why that is.

Professor Lithgow said: "If we look at checkpoint proteins as a gear, we have known for a long time that they drive the cancer engine; now we know that they also drive the longevity engine. This discovery has exciting potential as an area of inquiry into potential cellular links between ageing and cancer."

The research, which was completed at the Buck Institute in California where Dr Lithgow now works, involved genetically removing checkpoint proteins in the microscopic worm C. elegans. By doing so, the researchers caused a 15-30% increase in the worm's lifespan.

"Given the role that checkpoint proteins play in the development of cancer ?or in causing tumours when the proteins are defective ?the findings raise the question of whether genetic variations in these proteins in humans places some individuals at risk of cancer.

"Conversely, the check point proteins may set a genetic course for a shorter life but one that is free from cancer."

Dr Dale Bredesen, Chief Executive and Scientific Director at the Buck Institute, added: "This work brings a new richness and sophistication to the way we think about longevity interventions.

"If we're smart about it, we might be able to design strategies where you could keep checkpoint proteins active in dividing cells and stop them working in cells that no longer divide, such as brain cells.

"Increasing the survival of brain cells or 'neurons' could provide a new avenue of treatment for neurodegenerative diseases like Alzheimer's."


'"/>

Source:University of Manchester


Related biology news :

1. NASA links nanobacteria to kidney stones and other diseases
2. Insight into DNAs weakest links may yield clues to cancer biology
3. One gene links newborn neurons with those that die in diseases such as Alzheimers
4. Genetic links could unlock clues to leading cause of blindness
5. Climate model links higher temperatures to prehistoric extinction
6. Genetics links whale to two different ocean basins
7. Scientists discover a genetic switch that links animal growth and cancer
8. Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
9. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
10. Queensland scientists identify molecule that links both sides of the brain
11. Study links high levels of nitric oxide to infertility and sperm DNA damage
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/13/2017)... 13, 2017 According to a new market research ... Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and ... is expected to grow from USD 14.30 Billion in 2017 to USD ... 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... They call it the “hairy ball.” ... depiction of a system of linkages and connections so complex and dense that ... computer science at Worcester Polytechnic Institute (WPI) and director of the university’s bioinformatics ...
(Date:10/12/2017)... ... 12, 2017 , ... BioMedGPS announces expanded coverage of SmartTRAK ... module, US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats and Sealants ... sealants and biologic sealants used in surgical applications. BioMedGPS estimates the market will ...
(Date:10/11/2017)... ... 11, 2017 , ... The CRISPR-Cas9 system has ... and avoiding the use of exogenous expression plasmids. The simplicity of programming this ... gain-of-function studies. , This complement to loss-of-function studies, such as with RNAi ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
Breaking Biology Technology: