Navigation Links
Worm links cancer risk to ageing

The reason why people are at greater risk of developing cancer as they get older may be explained by research published today (June 2).

Scientists have discovered that a naturally produced protein that helps protect us from cancer may also determine how long we live.

The findings ?published in the highly respected journal Science ?open up a new avenue of inquiry into ageing as a risk factor for cancer.

"We have discovered that proteins that prevent cancer in humans by ensuring that cells don't divide if they are damaged also determine lifespan in the nematode worm," explained Professor Gordon Lithgow, who carried out the work at The University of Manchester.

"Our research has shown that these 'checkpoint proteins' ?thought only to operate in cells that divide ?function in cells that no longer divide as well. The fact that they appear to have dual functions opens a new way to study the connection between ageing and cancer."

Scientists have long known that, statistically, ageing is a huge factor for cancer but have so far struggled to understand why that is.

Professor Lithgow said: "If we look at checkpoint proteins as a gear, we have known for a long time that they drive the cancer engine; now we know that they also drive the longevity engine. This discovery has exciting potential as an area of inquiry into potential cellular links between ageing and cancer."

The research, which was completed at the Buck Institute in California where Dr Lithgow now works, involved genetically removing checkpoint proteins in the microscopic worm C. elegans. By doing so, the researchers caused a 15-30% increase in the worm's lifespan.

"Given the role that checkpoint proteins play in the development of cancer ?or in causing tumours when the proteins are defective ?the findings raise the question of whether genetic variations in these proteins in humans places some individuals at risk of cancer.

"Conversely, the check point proteins may set a genetic course for a shorter life but one that is free from cancer."

Dr Dale Bredesen, Chief Executive and Scientific Director at the Buck Institute, added: "This work brings a new richness and sophistication to the way we think about longevity interventions.

"If we're smart about it, we might be able to design strategies where you could keep checkpoint proteins active in dividing cells and stop them working in cells that no longer divide, such as brain cells.

"Increasing the survival of brain cells or 'neurons' could provide a new avenue of treatment for neurodegenerative diseases like Alzheimer's."


'"/>

Source:University of Manchester


Related biology news :

1. NASA links nanobacteria to kidney stones and other diseases
2. Insight into DNAs weakest links may yield clues to cancer biology
3. One gene links newborn neurons with those that die in diseases such as Alzheimers
4. Genetic links could unlock clues to leading cause of blindness
5. Climate model links higher temperatures to prehistoric extinction
6. Genetics links whale to two different ocean basins
7. Scientists discover a genetic switch that links animal growth and cancer
8. Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
9. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
10. Queensland scientists identify molecule that links both sides of the brain
11. Study links high levels of nitric oxide to infertility and sperm DNA damage
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
Breaking Biology News(10 mins):
(Date:8/17/2017)... ... August 17, 2017 , ... CNA Finance Chief ... provided a research update on Aytu Bioscience and cited promising increases in the ... Soulstring, prescription rates for Natesto® have more than doubled since March of this ...
(Date:8/16/2017)... ... ... While art and science are often thought of as two completely separate ... A Mesh Is Also a Snare, a group exhibition presented by the Philadelphia-based artist ... (EKG) on August 17 and run through September 30. An opening reception will be ...
(Date:8/15/2017)... STANFORD, Calif. , Aug. 15, 2017 After spending ... resources and support with crowdsourced data collection, GeneFo now offers this ... interested in aligning and amplifying support, adherence, and data collection vis ... with medical foundations mark the successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... Kenosha, Wisconsin (PRWEB) , ... August 15, 2017 ... ... introduced a new family of 6” modular downlights designed to stay tightly sealed ... applications, including areas where damp and wet location listings just aren't enough, such ...
Breaking Biology Technology: