Navigation Links
Worm hormone discovery may aid fight against parasitic disease

placing the missing hormones through replacement therapy can relieve the symptoms of the disease, much as providing the missing ligand to the worms restored their normality.

"The conservation of this pathway is remarkable," said Dr. Mangelsdorf, an investigator in UT Southwestern's Howard Hughes Medical Institute (HHMI). "This line of investigation has been much sought-after in terms of how the DAF-12 protein works and whether it had a hormonal regulator. Mother Nature has used this system from the very simplest nematode worms up to humans, not only employing the same types of proteins to do the job, but also the same types of hormones."

The dauer diapause occurs naturally in C. elegans when the worm senses from its environment that conditions are not favorable for maturing, such as when food is scarce. Dr. Mangelsdorf said cholesterol and other signals derived from the worm's food source are required to launch the series of biochemical events leading to the production of the hormonal ligand and continued development. Without these environmental signals and the ligand to activate DAF-12, the worm's life remains suspended.

The UT Southwestern research also may aid in the fight against human disease because the dauer diapause stage of C. elegans is very similar to the infective state of parasitic nematodes. According to the World Health Organization, such parasites infect about 2 billion people worldwide and severely sicken some 300 million, at least 50 percent of whom are school-age children.

In the infective state, parasitic nematodes, such as hookworms, remain in a larval, "resting" stage until they enter the human body, where they eventually migrate to the intestine and begin to mature. Dr. Mangelsdorf is investigating whether the homologue of DAF-12 in parasitic nematodes may regulate their maturing activity as well. If so, he said, the same pathway could be exploited to eradicate the pests, either by keeping them perpetually in a
'"/>

Source:UT Southwestern Medical Center


Page: 1 2 3

Related biology news :

1. Female sex hormones play a vital role in defense against sexually transmitted diseases
2. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
3. Measuring hormone cuts antibiotic use in half in pneumonia patients
4. Alcohol consumption disrupts breastfeeding hormones
5. VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Penguin chicks exposed to human visitors experience spike in stress hormone
8. Suppressing growth hormone in early adulthood may prevent cancer
9. Growth hormone is made in the brain, report scientists
10. Learning and memory stimulated by gut hormone
11. Hyena mothers give their cubs a helpful dose of hormones
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Worm hormone discovery may aid fight against parasitic disease

(Date:3/20/2015)... Mar. 19, 2015 Research and Markets ( ... Biometrics - Global Strategic Business Report" report to their ... Iris Biometrics in US$ Thousands. The report provides separate comprehensive ... Japan , Europe , ... and Latin America . Annual ...
(Date:3/18/2015)... 18, 2015 As mobile payments become ... smart wallets and apps continue to be introduced into the ... the mobile payment industry in focus today are:  NXT-ID, Inc. ... BABA ), Apple Inc. (NASDAQ: AAPL ... Inc. (NASDAQ: FB ) NXT-ID, Inc. ...
(Date:3/17/2015)... Emotient, the leader in facial expression ... availability of Emotient Analytics , the world,s ... facial expressions. The system analyzes videos of people ... services. It delivers audience response metrics - such ... derived from facial evidence of emotional states. Consumer ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... in Spanish . , Due to the large ... have claimed that they are millennia old but "there had never ... by the ecologist Bernat Claramunt from the Centre for Ecological Research ... has now analysed the ages of the famous olive trees and ...
... Fla. (May 16, 2012) Chlorothalonil, one of ... crops and golf courses, was lethal to a wide ... of South Florida researchers said Wednesday. Biologists Taegan ... in the journal Ecology Letters , report that ...
... leading event in reproductive medicine is less than two months ... journalism - and ESHRE,s annual meeting one of the best ... Istanbul promises to be as scientifically and clinically strong as ... in reproduction are expected this year. More than 1700 abstracts ...
Cached Biology News:The millennium-old olive trees of the Iberian Peninsula are younger than expected 2USF study: Common fungicide wreaks havoc on freshwater ecosystems 2European Society of Human Reproduction and Embryology 28th Annual Meeting -- Istanbul 2
(Date:3/25/2015)... March 25, 2015  Point-of-Care Partners, a leading ... firm, has launched the ePrescribing State Law Capsule ... of ePrescribing regulatory requirements in all 50 states ... landscape continues to change rapidly, so we have ... industry, and ultimately patients, need," said Tony ...
(Date:3/25/2015)... Researchers at Ancon Medical Inc. have ... enable broader and less invasive screening for cancer, ... breath screen. The Minnesota-based medical device maker will ... Administration (FDA) approval process and is targeting a ... Tagging device. , Ancon Medicals nanoparticle breakthrough comes ...
(Date:3/25/2015)... /CNW/ - The Gairdner Foundation is pleased to ... recognizing some of the most significant medical discoveries ... the world,s most esteemed medical research prizes, the ... a $100,000 (CDN) prize to each scientist for their work. ... and innovation across the country, inspiring the next ...
(Date:3/25/2015)... March 25, 2015 Proove Biosciences ... is excited to announce the success of their commercially ... Testing to Optimize the Management of Pain, at ... in National Harbor, Maryland on Thursday, March 19th, 2015. ... former AAPM President Lynn Webster , M.D., former ...
Breaking Biology Technology:Point-of-Care Partners Launches the ePrescribing State Law Capsule 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2
... (Nasdaq: KERX ) today announced the appointment of ... Executive Officer, replacing Michael S. Weiss, effective immediately. Mr. ... since September 2007. Mr. Tarnok spent the majority of ... as Finance Director -- US Manufacturing. From 2000-2007, Mr. ...
... following letter to James Wilson, Lead Independent Director of Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ... ... Wilson, Lead Independent Director, Amylin Pharmaceuticals, Inc., ... Jim:, If you are really serious about settling what you consider a debilitating, ...
... the biotechnology industry in Georgia ATLANTA, April 23 ... Georgia Governor Sonny Perdue as 2009 Governor of the ... the biosciences in Georgia. "Governor Perdue,s support of ... Georgia," said Jim Greenwood, President and CEO of BIO. ...
Cached Biology Technology:Keryx Biopharmaceuticals, Inc. Announces Michael P. Tarnok as Interim Chairman and Chief Executive Officer 2Icahn Asks Amylin to Allow Discussions With Eastbourne 2The Biotechnology Industry Organization Honors Georgia Governor Sonny Perdue as Governor of the Year 2The Biotechnology Industry Organization Honors Georgia Governor Sonny Perdue as Governor of the Year 3The Biotechnology Industry Organization Honors Georgia Governor Sonny Perdue as Governor of the Year 4
GENOMIPHI V2 DNA AMP KIT 25RXN, 1 EA. Category: Genomics DNA Amplification....
EPH electrode, anode, 1. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
... major advantages over other RNA precipitation methods in ... carbohydrates. It is the method of choice for ... RNA preparations. Note, LiCl precipitation may not remove ... the RNA is to be used for RT-PCR, ...
LIVE/DEAD® Cell-Mediated Cytotoxicity Kit *for animal cells* *2000 assays*...
Biology Products: