Navigation Links
World's smallest cancer detection device

Researchers at the Albert Einstein College of Medicine of Yeshiva University have received a $2 million grant from the National Cancer Institute to study tumor "microenvironments" --where tumors interact with surrounding tissues, cells and chemicals in ways that all too often encourage cancer cells to invade other areas of the body in the process known as metastasis.

With the new NCI grant, Dr. John Condeelis, co-chair of anatomy and structural biology at Einstein and the principal investigator of the newly funded program, and his Einstein colleagues will team up with researchers at the College of Nanoscale Science and Engineering (CNSE) of the University at Albany to develop a next-generation microchip that, when placed in a cancerous mass, can gather information on the presence of metastatic cells that would demand more aggressive cancer therapy.

"The NCI has placed a very high priority on understanding the 'dialogue' in tumor microenvironments that appears crucial for causing cancers to spread," says Dr. Condeelis. "This five-year Tumor Microenvironment Network grant will allow Einstein to influence the way research is carried out in this emerging and important field."

Dr. James Castracane, the project's co-investigator, who is head of the Nanobiosciences Constellation at CNSE, said, "By integrating cutting-edge science and engineering at the nanoscale level with vital biomedical research, it is our intent to provide deeper understanding of the causes of cancer metastasis and migration ? knowledge that is of critical importance in the treatment and, ultimately, prevention of cancer."

Dr. Condeelis has used the multiphoton confocal microscope to directly observe cellular interactions in the tumor microenvironment of live animal models of breast cancer. By placing an artificial blood vessel near tumors, he was able to collect motile cancer cells for study and to predict--by the presence or absence of certain signaling molecules-- whether the tumor cells have the potential to metastasize.

The Einstein and Albany researchers will use nanotechnology, which involves studying and working with material on the molecular level, to design a "microchip" version of the artificial blood vessel that Dr. Condeelis has used successfully in animals. The microchip will be assembled from nanoscale components so that several different functions can be carried out within a very small package. The goal: to implant these tiny microchips ?just two to three cells in diameter and a tenth of a millimeter in length ?in human tumors, where they would remain for days or weeks. The chips would report remotely to scanners that would "read" them on the nature of the cells that infiltrate them--in particular, on whether metastatic cells are present that would call for more aggressive cancer therapy.

In 2005, Einstein formed an alliance with UAlbany's CNSE to advance education and research in the rapidly growing fields of nanobiotechnology and nanomedicine. "This NCI grant marks a true milestone for this partnership, which combines the unique expertise and resources of both institutions to apply nanoscale principles to detect diseases and develop treatments for them," says Ira M. Millstein, chairman of the Einstein Board of Overseers. "We are committed to ensuring that the Einstein-Albany alliance will lead the nation in efforts to use nanotechnology to improve peoples' lives."


'"/>

Source:Albert Einstein College of Medicine


Related biology news :

1. Worlds largest rainforest drying experiment completes first phase
2. A New Era of Hope for the Worlds Most Neglected Diseases
3. Worlds pledge to halve hunger by 2015 looks like empty promise
4. Worlds largest flower evolved from family of much tinier blooms
5. Worlds leading scientists announce creation of Encyclopedia of Life
6. New study of the worlds smallest elephant
7. Small, smaller, smallest -- The plight of the vaquita
8. Viral DNA sequence a possible trigger for breast cancer
9. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
10. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
11. Columbia research lifts major hurdle to gene therapy for cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... Research and Markets has announced the addition of the ... offering. The report forecasts the ... at a CAGR of 12.28% during the period 2016-2020. ... analysis with inputs from industry experts. The report covers the market ... also includes a discussion of the key vendors operating in this ...
(Date:6/22/2016)... BETHESDA, Md. , June 22, 2016  The American ... by Trade Show Executive Magazine as one of ... Summit on May 25-27 at the Bellagio in ... based on the highest percentage of growth in each of ... number of exhibiting companies and number of attendees. The 2015 ...
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Alex,s Lemonade Stand Foundation (ALSF), ... it will open a state-of-the-art bioinformatics lab, using ,big ... This announcement comes as Liz Scott , co-executive ... Cancer Moonshot Summit in Washington, D.C. ... a participant and advocate of pediatric cancer research and ...
(Date:6/27/2016)...  Global demand for enzymes is forecast to ... $7.2 billion.  This market includes enzymes used in ... production, animal feed, and other markets) and specialty ... and beverages will remain the largest market for ... products containing enzymes in developing regions.  These and ...
(Date:6/27/2016)... June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" ... by its major shareholders, Clean Technology Fund I, LP ... States based venture capital funds which together ... (on a fully diluted, as converted basis), that they ... their entire equity holdings in Biorem to TUS Holdings ...
(Date:6/27/2016)... , June 27, 2016  Sequenom, Inc. (NASDAQ: ... to enabling healthier lives through the development of innovative ... of the United States denied ... that the claims of Sequenom,s U.S. Patent No. 6,258,540 ... eligibility criteria established by the Supreme Court,s Mayo Collaborative ...
Breaking Biology Technology: