Navigation Links
World's smallest cancer detection device

Researchers at the Albert Einstein College of Medicine of Yeshiva University have received a $2 million grant from the National Cancer Institute to study tumor "microenvironments" --where tumors interact with surrounding tissues, cells and chemicals in ways that all too often encourage cancer cells to invade other areas of the body in the process known as metastasis.

With the new NCI grant, Dr. John Condeelis, co-chair of anatomy and structural biology at Einstein and the principal investigator of the newly funded program, and his Einstein colleagues will team up with researchers at the College of Nanoscale Science and Engineering (CNSE) of the University at Albany to develop a next-generation microchip that, when placed in a cancerous mass, can gather information on the presence of metastatic cells that would demand more aggressive cancer therapy.

"The NCI has placed a very high priority on understanding the 'dialogue' in tumor microenvironments that appears crucial for causing cancers to spread," says Dr. Condeelis. "This five-year Tumor Microenvironment Network grant will allow Einstein to influence the way research is carried out in this emerging and important field."

Dr. James Castracane, the project's co-investigator, who is head of the Nanobiosciences Constellation at CNSE, said, "By integrating cutting-edge science and engineering at the nanoscale level with vital biomedical research, it is our intent to provide deeper understanding of the causes of cancer metastasis and migration ? knowledge that is of critical importance in the treatment and, ultimately, prevention of cancer."

Dr. Condeelis has used the multiphoton confocal microscope to directly observe cellular interactions in the tumor microenvironment of live animal models of breast cancer. By placing an artificial blood vessel near tumors, he was able to collect motile cancer cells for study and to predict--by the presence or absence of certain signaling molecules-- whether the tumor cells have the potential to metastasize.

The Einstein and Albany researchers will use nanotechnology, which involves studying and working with material on the molecular level, to design a "microchip" version of the artificial blood vessel that Dr. Condeelis has used successfully in animals. The microchip will be assembled from nanoscale components so that several different functions can be carried out within a very small package. The goal: to implant these tiny microchips ?just two to three cells in diameter and a tenth of a millimeter in length ?in human tumors, where they would remain for days or weeks. The chips would report remotely to scanners that would "read" them on the nature of the cells that infiltrate them--in particular, on whether metastatic cells are present that would call for more aggressive cancer therapy.

In 2005, Einstein formed an alliance with UAlbany's CNSE to advance education and research in the rapidly growing fields of nanobiotechnology and nanomedicine. "This NCI grant marks a true milestone for this partnership, which combines the unique expertise and resources of both institutions to apply nanoscale principles to detect diseases and develop treatments for them," says Ira M. Millstein, chairman of the Einstein Board of Overseers. "We are committed to ensuring that the Einstein-Albany alliance will lead the nation in efforts to use nanotechnology to improve peoples' lives."


'"/>

Source:Albert Einstein College of Medicine


Related biology news :

1. Worlds largest rainforest drying experiment completes first phase
2. A New Era of Hope for the Worlds Most Neglected Diseases
3. Worlds pledge to halve hunger by 2015 looks like empty promise
4. Worlds largest flower evolved from family of much tinier blooms
5. Worlds leading scientists announce creation of Encyclopedia of Life
6. New study of the worlds smallest elephant
7. Small, smaller, smallest -- The plight of the vaquita
8. Viral DNA sequence a possible trigger for breast cancer
9. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
10. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
11. Columbia research lifts major hurdle to gene therapy for cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2017)... Australia , March 9, 2017 ... the prestigious World Lung Imaging Workshop at the University ... , was invited to deliver the latest data to ... globally recognised event brings together leaders at the forefront ... developments in lung imaging. "The quality ...
(Date:3/7/2017)... 2017 Brandwatch , the leading social intelligence company, ... Trust to uncover insights to support its reporting, help direct ... The UK,s leading youth charity will be using Brandwatch Analytics social ... a better understanding of the topics and issues that are a ... ...
(Date:3/6/2017)... , March 6, 2017 Mintigo ... technology, today announced Predictive Sales Coach TM , ... actionable sales intelligence into Salesforce. This unique AI ... their sales organizations with deep knowledge of their ... for intelligent engagement. Predictive Sales Coach extends Mintigo,s ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... ... NetDimensions appoints Bill Mastin, a learning technology veteran, as its new Senior Vice ... technologies industry, Mastin joins NetDimensions from the New York office of learning and engagement ... served as SVP of the North America offices and prior to that, he held ...
(Date:4/20/2017)... ... ... Parallel6™ , the leader in mClinical™ technologies for improving patient enrollment, ... of the 2017 Top 10 eClinical Trial Management Solution Providers by Pharma Tech ... take pride in honoring Parallel6 as one of the top 10 companies that are ...
(Date:4/20/2017)... Israel , April 20, 2017  BrainStorm ... stem cell technologies for neurodegenerative diseases, announced today that ... Alliance for Regenerative Medicine,s (ARM) 5 th Annual Cell ... at 09:40 EDT in Boston . ... Chief Medical Officer & Chief Operating Officer, will participate in ...
(Date:4/19/2017)... ... 2017 , ... A number of new instruments have recently emerged to accommodate ... Protein and Cell Analysis Education Webinar Series , will focus on advances in ... and future applications. , Many flow cytometers have unique capabilities and the Attune ...
Breaking Biology Technology: