Navigation Links
World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

A University of Alberta and Capital Health surgeon, well known for his pioneering work in developing the Edmonton Protocol treatment for diabetes, has taken another important step in the fight against diabetes.

On January 19, at Kyoto University Hospital, Dr. Koichi Tanaka and Dr. James Shapiro, along with a team of Japanese surgeons, removed part of a 56-year-old woman's pancreas. Dr. Shinichi Masumoto then isolated the living islets in the Kyoto Centre for Cell and Molecular Therapy. Under Dr. Shapiro's supervision, the team then transplanted the insulin-producing cells into the woman's 27-year-old diabetic daughter.

The transplanted islets began producing insulin within minutes, explains Dr. Shapiro. "The reason I'm so excited about this is because normally the Edmonton Protocol is done with islets from brain-dead organ donors. Those islets are often severely injured from cold storage, transport time and the pancreas is severely damaged by toxins which circulate in the blood stream after brain death."

"Our expectation is that these islets from near-perfect organs will work better, although it's too early to tell," he says.

The recipients use the same drugs to prevent organ rejection as are used in the Edmonton Protocol.

Dr. Shapiro was invited to participate in the operation in Kyoto, Japan, where he originally did living donor liver transplant training with Dr. Tanaka. Dr. Masumoto was previously based in Seattle and had been involved in Dr. Shapiro's international trial of the Edmonton Protocol before returning to Japan. Dr. Shapiro first suggested the idea of starting a living donor islet transplant program in Kyoto while lecturing there three years ago. Cadaveric organ donors are scarce in Japan, and living donation has very established roots in liver and kidney transplantation there.

"Living donor islet transplants could allow many more desperate patients with type 1 diabetes to get successful islet transplants, " says Dr. Shapiro. "The donor operation is relatively safe, but is not entirely devoid of serious potential risk," he added.

A shortage of donor islet cells is the biggest obstacle preventing implementation for all patients who need it, Shapiro added.

The mother of the diabetic daughter was in perfect health, while her daughter has been on the cadaver donors transplant list since September 2004. Before the surgery, the woman had been subject to severe low blood sugar coma attacks, and her glucose control has been transformed by the transplant.

Related Web Site:

http://www.med.ualberta.ca/islet


'"/>

Source:University of Alberta


Related biology news :

1. World-first technology enables study of ancient bacteria
2. Living with salt
3. Living anti-HIV gel shows early promise
4. Living taste cells produced outside the body
5. Living laboratory found on shoreline statues
6. Study: Living coral reefs provide better protection from tsunami waves
7. Living view in animals shows how cells decide to make proteins
8. Living with water scarcity -- world must act now
9. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
10. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
11. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2016)... 2016 --> --> ... Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & ... the border security market and the continuing migration crisis in ... Europe has led visiongain to publish this unique ... --> defence & security companies in the border ...
(Date:3/14/2016)... http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ( ... --> DERMALOG, le leader de l,innovation ... d,empreintes digitales pour l,enregistrement des réfugiés en Allemagne. ... produire des cartes d,identité aux réfugiés. DERMALOG dévoilera ...
(Date:3/9/2016)... 2016 This BCC Research report provides an ... RNA Sequencing (RNA Seq) market for the years 2015, ... and reagents, data analysis, and services. Use ... RNA-Sequencing market such as RNA-Sequencing tools and reagents, RNA-Sequencing ... affecting each segment and forecast their market growth, future ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... May 23, 2016 , ... ... solutions and services based in Aurora, Ohio, has broken ground on a new ... the Research Triangle Park area, this new location solidifies a commitment to business ...
(Date:5/20/2016)... ... ... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma ., is proud ... of their own patients with the VetStem Cell Therapy. Each of these veterinarians has ... patients. , The veterinarians are Dr Ross Rich former owner of Cave Creek ...
(Date:5/20/2016)... MD (PRWEB) , ... May 20, 2016 , ... The ... with Listeria, as reported by Food Safety News on May 12, 2016(1), demonstrates the ... to Ted Olsen, CEO of Baltimore-based biotech firm, PathSensors, Inc. , ...
(Date:5/19/2016)... May 19, 2016 There is ... recover given the relentless pressures in pricing and lack ... the investors circle though - numerous opportunities are up ... today,s session, ActiveWallSt.com,s presents four names in this sector: ... Pharmaceuticals Inc. (NASDAQ: VTAE ), Anthera Pharmaceuticals ...
Breaking Biology Technology: